Story so far

[aberdeen577]

Hello Everyone,
Right now my stats are :
E antigen negarive
S antigen positive
qHBsAg 16.40 IU/ML
anti HBs <10.00 IU/ML
ALT 29
AST 24
GGT 21
ALP 37
Calcium 2.27 mmol/L
adjusted calcium 2.27 mmol/L

I am currently taking
TDF 1x245mg tablet/day (since September 2011)
Simvastatin 1x20mg tablet per day
Vitamin D3 1x5000IU tablet per day
Blueberry extract 3x60mg tablets per day
Selenium tablet (1) per day

I met with my consultant today and I am so depressed now and disappointed. He will not put me on peginf.because:
-my age
-I have severe fibrosis saying inf can cause liver damage and decompensation
-caucasion
-he has no clinical evidence that it will work with someone so low as 16IU. Says surface antigen needs to be around 500IU/ML for it to work
-it is dangerous to take
-my ALT and AST are too normal; would prefer them elevated
I feel very low now and cannot understand why he cant at least try it for a few months at least.

My question to my learned friends is what can I do now?  I would like to self medicate other oral drugs as a first line to seroconversion before inf. Stef, can you suggest a drug regime that I could look at taking? Inf looks to be a little way off for me right now. I am in N Ireland and I do not have any choice of where to go next.
Thank you.

[aberdeen577]

we actually dont know what stab vit d can do on hbsag quantity, we need many patients on long term tdf or etv to see if there is any effect,

And I totally agree Stef.  I have had good changes in surface antigen but they started before I had Stabilised vit D. Its just a pity I had no baseline before I started TDF in 2011; that would have given us a better idea. I did have 6 months of alpha interferon ( 3 injections per week) back in 2000 and this may have helped lower sag in the first place?

I cant wait to see if my nagalase has been lowered. If it has then we can probably say that this is then accelerating the demise of the surface antigen. If, on the other hand, the nagalase has not been reduced then the stabilised vit D has not helped in any way to reduce surface antigen. As soon as I get the result I will post here.

[stef2011]

we actually dont know what stab vit d can do on hbsag quantity, we need many patients on long term tdf or etv to see if there is any effect, especially those on low hbsag where we know there is an immune activity to be enhanced.
we know for sure that it amplifies immune responses by activating macrophages from the studies and human trials available but my guess is if there s nothing to amplify it doesn t work

you and me are the only ones who tried it, i too had a decrease of hbsag when i took it but i am on too many things and i also had to stop it.

so if also joc2011 is on long term tdf or rtv or naturally hbvdna und you are the first examples of its effect

[stef2011]

it would have been better keeping the same, the stabilized is the most potent form of gcmaf, if you are still ontime change the order.
i ve been told this by a scientist so you can be sure that "stab vit d" is the most potent form

goleic is gcmaf plus oleic acid (no vitamin d bound to gcmaf).i don t know if there is any difference between gcmaf+oleic acid+vit d althougher and gcmaf+oleic acid and high serum levels of vit d...the research has shown that high serum levels of vit d and oleic acid made vdr receptor attachment, with no vit d and oleci acid no attachment

this make also sense with the fact that all viruses hijack vit d pathways to keep low vdr repator attachment

[aberdeen577]

Hi Stef,
As you suggest I will have fibroscan done again after 24 weeks on stabilised vit D (GCMAF). Interestingly, GCMAF now have GOleic  vitD on the site for sale and not stabilised vit D. When I asked them they said I could still order either but interesting that the stabilised version is not readily available . I have ordered the GOleic for the next supply.

[aberdeen577]

Hello,

Can you please give us your daily routine. Are you still on TDF, selenium, Vit D3 etc...etc.

Firstly as Stef has indicated above stabilised vit D is NOT  a cure by eliminating surface antigen. I started TDF in sept 2011 after having been told I had severe fibrosis. I contracted the virus sometime in the early nineties as an adult but had never any symptoms and only found out on blood tests for pension.
Each day I take the following::

TDF 1x245mg tablet/day (since September 2011)
Simvastatin 1x20mg tablet per day
Vitamin D3 10,000IU  per day
Blueberry extract 3x60mg tablets per day
Selenium tablet (1) per day
4 sublingual drops GCMAF twice per week.
5ml pure fish oil (from Italy with high EPA and DHA) each evening
garlic tablet each day

I am sure, again as Stef has stated, that the GCMAF is definitely boosting the immune system and it will be very interesting to see the next nagalase result. It is not the answer to all though.

[aberdeen577]

Fantastic results Aberdeen. I have been on Stab Vit D. done 2 vials already. Will order another vial. This clearly works from your rsults. Where did you have ur nagalese test done in the UK aberdeen?

I have had them done first time in 352 healthcare in Belfast and the result was 2.20. I have gone to them a second time and should have the new result in approx. 2 weeks time. I believe the sample had to be sent to mainland Europe for the test. BUT, please note that my sag was 12.80IU/ML in November 2012 (my first time for checking and therefore my baseline) and then 16.40 IU/ML in March 2013 and then 3.10IU/ML in November 2013. I started sublingual stabilised vit D at the end of November as well as increasing my D3 input from 5000IU (which I had been taking for the previous 12 months) to 10,000IU. I take approx. 4 drops two times each week so the medication does not last me for 8 weeks. I will continue to take it for 24 weeks though. Also interesting to note that my 25OH level is still only 83 ng/ml even after increasing to 10,000 IU D3 in November last!