it would be useful if they study these breakthru but as shown on studies they look not interested in this, a simple check of hbsag quant and cytokines during breakthrough could tell if this is immune response, resistance or missing pills
as for resistance a study with ultradeep sequence is also needed to know the minor viral populations
Can anybody explain how that virologic breakthrough works ? I mean since there is no resistance how does the virus breakthrough ?
i think there are two types when not resistance:
patients forgetting to take the pills
immune response, maybe intf gamma purging virions hidden inside infected cells.i myself had this in october 2012 when my hbvdna becomes 31iu/ml while on entecavir plus tenofovir, at the same time hbsag went from about 4300iu/ml to 3600iu/ml immediately exactly the same days.
this happened exactly when i tried daily imiquimod suppository, this probably increased immeun response of interferons and cytokines and this was the result....at the same time i also had creatinine increase to 1.2, vision decline and all the symtoms of interferon/cytokines inflammation, do daily imiquimod is borderline with sides effects
Steff, what do you connect vision decline with?
I have also vision decline since the last year, I wonder if it is connected to hbv anyhow?
sorry used wrong words in english, blurred vision...it is a side effect of intf too and with imiquimod it lasts about 1 day, it is not so heavy you can see normally but not so clear
I see, probably I just getting older...
That is all BS what they write. These drugs only stop viral assembly in blood. Inside the liver the damage process goes on.
And the rest of the body damage do to toxicity of these drugs why they dont report it?
High blood pressure
Thyroid work impairment
Hair growth stop
Lympodystrophy and muscle loss
Lactic acid build up
possilble dna damage
fatty liver build up
These people have access to better drugs but dont use them. Instead it is tdf or etv. Dont people get it that these drugs kill at about the same rate as hbv does?
It is enough talk about these nucs. Demand better drugs people.