From which planet are these doctors from?truvada is not approved for hbv and just adds kidneys toxicity to tenofovir for nothing,tenofovir or entecavir are the drugsfor hbv
Taking a drug to prevent an infection while there arethousands if not more potential infections is not smart, just use a condom which prevents so many more infections without worsening health
This is my opinion but truvada is not hbv approved because the toxicity vs benefits are worst than tdf or etv
Truvada is not hbv approved, because Gilead never performed the large trial that is necessary to achieve approval.
Truvada is TDF +FTC. FTC is identical with lamivudine except that a fluor atom was added to the ring.
the combo was shown to have substantial more hbv suppressing power due to some peculiar synergy mechanisms.
it is now the drug of choice for patients that show a reduced response to TDF presumably due to some partial mild resistance mutations. The alternative is the combo TDF plus entecavir. It is hard to say which works better in this situation, but FTC does not introduce permanent mutations into mitochondria while entecavir is principally capable of doing that.
It is indeed surprising that a drug was approved as an infection prevention. It must be that at least by the formal criteria Truvada had such mild side effects that such an approval was possible. I agree that there are certainly less toxic ways to prevent sexually mediated infections.
it is not clear when was the last time your measured your ALT/AST.
Can you summarise only your ALT and AST results in a more clear format.
I guess one would expect ALT and AST to go down by now.
From my limited knowledge I could assume that your immune system got activated due to sudden reduction of virus in you.
Take another measurment of DNA...by now it should be lower then the pre-treatment value (which was in millions).
If your ALT and AST don't go down on the next measurement you could also get a second opinion from another doctor as to why that is the case. Try to find someone experienced (usually doctors in bigger hospitals are more knowledgable).
As you are a gay male I would advise you not to have random sexual partners because i have read that gay males have drastically greater prevalence Hepatitis D. You don't want to be catching Hep D (or HIV) on the top of Hep B, and nothing (including Truvada) can't prevent you from Hep D which usually kills those infected with it 5-10 years after one is infected, and is a much bigger concern to you then HIV at this point.
If fact I would advise you practicing sex abstinence by mastrubation when your sexual desires arise.
Forgot to mention: there is no effective medicine for the treatment of Hep D, unfortunately.
Phase 2 clinical trial for Hepatitis D treatment:
Eiger Bio completes enrollment in mid-stage study of lonafarnib in hepatitis D
hep D is rare worldwide and usually chronic if taken with hbv at first infection but usually cleared if taken later on, the point is it is so heavy on the liver and cannot be blocked, it is very infective but i guess a condom would be enough
researchers in pisa (one of the most advanced researchers in the world) told me to pay high attention to dentists only and to be the first patient of the day because hdv can be easily spread in the air and reinfect at the dentists.
Actually it is reverse, hep d usually clears if one gets infected at the same time with hep b and hep D, and stays chronic if one gets it on the top of the allready present (estabilished) hep B chronic infection.
Thanks for sharing the advice from pisa researchers.
p.s. advices such as this related to the dentist should be made a sticky, visible to all forum posters who register now or 3 years from now...unfortunately they get lost on the medhelp implementation of the forum once the topic becomes inactive.
I just noticed I had a typo in my posts with stating my viral load pretreatment being in the millions. My original results were
Hepatitis B Quant >1000000000 IUnits/mL
LOG 10 HBV DNA >9.00 IUnits/mL
no i meant you get hbv and hdv at birth, when older even if hbv is present hdv is cleared, we also have a member here with cleared hdv and chronic hbv but again it is so rare that studies are so few who knows how really reliable
while hbv+hdv is cleared as adults and not infective at all without hbv
hbvdna doesn t matter its cleared by tdf or etv whatever and the highest the less liver damage because immune tolerant, remember its our immune system to damage the liver, not hbv
Your original elevations of ALT and AST were 99% caused by hepatitis