Which is the best choice

[secrect_garden]

HI everyone and Happy new year!
After 2 year of marriage, we will to have a baby soon. My baby had 7 weeks, however hepatis B  put me into difficult situation
I am currently under treatment with tenofovir, 6 month before to know get pregnancy.This is my profile
July 2014
Alt 100
Ast 50
Fibroscan 5.8
HBv dna: 9.8*10log 8 iu/ml
After 3 month. October 2014
Alt 30
ast 32
Fibrocan 6.2
hbv dna: 5.6*10 log 3 iu/ml
and the most imfortance things hbeag : positive
My doctor tell me keep to use tenofovir during pegnancy because my hheag is positive, if i stop using medication the virus will flare up and my child have a greater change to get infected hep b. However, she says the choice upon to me
I am worry to dead because i know tenofovir has some negative effect on baby : kidney' function and bone loss.
When I take this pill, I alway nauses after eating, usual muscle pain and a bit tideness. These symptoms is not severe but it appears.
I don't know which the best choice for me and my child?
Can medhelp mother share me your experience? Should I continue take these pills? or stop it and waiting until the day my baby be born and vaccinated?

[StephenCastlecrag]

Previously, Tenofovir was recommended only in the third trimester to further reduce the risk of vertical transmission in women with very high viral load and HBeAg+ve, because doctors were cautious about the effect of TDF on the fetus in the early period of pregnancy. However, with extensive clinical trials and observations from pregnant women with HIV/AIDS treated with TDF, doctors now consider it safe to use TDF throughout pregnancy. There are two concerns in pregnant women with HBV - the major one is the health of the baby, then the health of the mother. Do consult your doctors to seek assurance.

[secrect_garden]

Thank for your helpful information. I think I will ask my doctor whether  I should stop using tenofovir until the last trimester I will check hbv dna , if it increase I will use medication again
Finally, i have just got the lastest test which just taken a week ago
Hbv dna : 1.19*1000 cp/ml
Hbeag: positive

[StephenCastlecrag]

Generally, Tenofovir is recommended throughout pregnancy, even during breastfeeding.
http://www.medscape.com/viewarticle/807416_6
"Treatment With Tenofovir

Although TDF has been used in HIV or HIV/HBV coinfected mothers, little data exist for mothers with HBV monoinfection. A recent case series study evaluated HBeAg-positive mothers with HBV DNA > 7 log10 copies/mL who received TDF 300 mg/d at the third trimester.[40] All infants received hepatitis B immune globulin (HBIG) and the three-series vaccination. A significant reduction in serum HBV DNA was achieved at delivery compared with baseline (mean 5.25 ± 1.79 vs. 8.87 ± 0.45 log10 copies/mL, respectively; p < 0.01). The 11 infants born from mothers who received TDF had no obstetric complications or birth defects. All infants were HBsAg-negative at 28 to 36 weeks after birth. A large prospective randomized control trial studying the prevention of HBV MTCT with the use of TDF in the third trimester is currently being conducted in Asia with anticipated trial results available in 2014.[41] "