hbv+hdv few data on interferon+nuc combos

[stef2011]

https://docs.google.com/viewer?a=v&pid=explorer&chrome=true&srcid=0B_yFgxI8KNcRM2RkMWZmMzAtZmY0ZC00OWFmLWFhZDYtZDdmYzZhMzI4Yjk2&hl=en

since we have no data available on interferon+etv or tnf i looked in to combo therapies for hbv+hdv, the data is still very few but at least we start to know that:
interferon+telbivudine lowers hbsag very fast, 1log even in 24weeks only but miopathy sides can happen and they are due to telbivudine probably since present also in mono

interferon+tenofovir+ftc, a single case of hbv+hdv cleared in 10 months combo, no relevant sides, interferon can be the only drug in this combo with relevant sides

interferon+entecavir, still no data, entecavir potency is similar to telbivudine on hbvdna and higher on hbsag, so this combo, therorically, should have same results but no sides since etv has none

addition of nitazoxanide to these combos might lower hbsag even more and the fact that ntz has no sides makes it the ideal drug for these combos

[fishooo]

my hdv rna load is 500,638 iu/ml
also compensated cirhosis taking tenefovir will i be able to regress it?

[stef2011]

interferon+telbivudine lowers hbsag very fast, 1log even in 24weeks only but miopathy side......

sorry it is not miopathy but Neuropathy sides.

my opinion:
if this combo should be avoided also telbivudine should be avoided as hbv therapy even more because also monotherapy with telbivudine has Neuropathy sides, and much worst than combo it has high resistance rates too
the question is why telbivudine was approved if it doesn t work as mono or combo....

[stef2011]

forgot to menthion that interferon+tnf trials have been made also on hcv+hiv coinfected patients for 48weeks no relevant sides except the ususal ones from interferon