hep b Test results

[manmadan]

Can Any one tell me ....what is to be done for my results
HbsAg - 2650 IU/ml
Anti HBs - 67.5 IU/ml
HbeAG -Negative
HBV DNA PCR- 24 IU/ML
LFT - Normal

Pl. suggest for further. I am healthly Carrier for 8 years(Since I know)

[manmadan]

hbsag is stable for 1year it ranges from 15500-17700

[stef2011]

you look like having mutated hbsag if hbsag stays that high, is hbsag getting lower or stable?

[manmadan]

Hi stef2011,

Last april my test results are:
hesag -17700 iu/ml
anti hbs - 173 in/lit

just checked the AST level is high 67 (normal is 5-45 only).
but alt is normal.
Worried little bit.

[stef2011]

if ast and alt are normal you must not treat, it is not hbv to make damage but our immune system and if you have no immune response you have no damage

[john77231]

Hi i would like some help
I am Hep B positive
Core negative
HBAg negative
HB Ab positive
my viral load is 2 millions
my doctor told me that i dont need any medication at this point
are there any natural remedies that i should be taking

[stef2011]

it is a research level test, full genome hbv sequencing, you have to look for a research center for it, but if it is difficult to find in india dont worry about it chnces are very high you have that mutant

[smile_boy]

I hope Mutation test is available in Hitech , Labs Chennai.

HBV - YMDD MUTATION DETECTION -


_http://www.hitechlabsindia.com/2010/testnew.asp?cat=H

[manmadan]

how to check the mutation of hbsag ? what is the test name sothat I would check it in india?

Manmadan

[stef2011]

hbsag mutants are also at very high risk for cirrhosis and liver cancer so if it was possible to confirm hbsag mutation i d go for treatment immediately

in italy hbsag sequence is available at some hospitals, did you find a place where to have it confirmed?

[stef2011]

what about hbvdna and ast/alt

definitely an hbsag mutated case

have you checked vitamin d25oh levels?

interferon would be good but better prepare to have a good interferon response before going at it:

vitamin d levels 80-90ng/ml, to reach these levels you need vit d3 supplemnts 10.000iu daily and need to check calcium and d serum levels every 3 months

if hbvdna is detactable it is better to use tenofovir for 1-3 years to make hbvdna und, rescue your immune response to hbv so that interferon works

see our posts about: aldara, alinia,vitamin d3, simvastatin, all ahev mild effect but all can boost interferon response

do not start interferon ow because hbsag levels over 1500iu/ml have no hbv clerance, sequential treatment with tdf for 1-3 years and then peginterferon add on worked on levles of hbsag around 8000iu/ml but too little patients so it ibetter to lower hbsag as much as possible before interferon and tenofovir, alinia, aldara cream and vit d3 may help a little on this while simvastatin may boost response when interferon is added

[manmadan]

Dear Stef,

after almost a year I checked my blood..
hesag -17700 iu/ml
anti hbs - 173 in/lit

Presently not taking any medicines....
can i go for interferon....injecion....

rgds,
Manmadan

[raja1972]

Thanks a lot.

[smile_boy]

For HbsAg Quantitative (iu/ml)

Try it in Hitech Diagnostic cente ,No.1 Millers Road , Kilpauk Branch Chennai.(ph 044-42919999)

It cost 400 Rupees.Method is ECLIA

If you want Abboht architecture , try it in Ramakrishna Hospital, Coimbatore

[raja1972]

Hi Manmadan,
Where can i take HBSAG quantitative test in chennai, India?

[stef2011]

the full articl might be interesting on hbsag/hbsab cronic hbv, i dont understand what they mean by serotype
you should check both the genotypes of your hbv infection to know if you are infected with more than one genotype and the hbsag a mutation in a research lab.in any case both interferon and the other drugs work in ur case

http://www.springerlink.com/content/w4g11613k84062pm/

Abstract
The pathogenesis of HBsAg (+)/HBsAb (+) double positive hepatitis B virus infection was investigated by simulating HBsAg/HBsAb coexistence in vitro and establishing HBsAg/HBsAb double positive model in vivo. Eukaryotic expression plasmids PCI-SY, PCI-adw, PCI-adr, PCI-ayw, which expressed S gene product of different serotypes, were constructed and transfected into HepG2 cells. Recombinant proteins were purified from the transfected cells. At the same time, HBsAg mouse antiserum was obtained by immunizing mice with PCI-SY plasmid. HBsAg/HBsAb coexistence was simulated using these antigens and antiserum. Furthermore, the expression plasmids expressing different serotypes of S gene product including PCI-adw, PCI-adr, and PCI-ayw were injected into mice via tail vein. HBsAg and HBsAb in mice sera were tested at the first and 7th day respectively after antigen plasmids injection. Both in vitro simulation and in vivo animal models demonstrated that HBsAg antigen and HBsAb of the same serotypes could not coexist, but HBsAg antigen and HBsAb of different serotype could coexist. HBsAg/HBsAb double positive hepatitis B virus infection could be due to infection of viruses of different serotypes.

[stef2011]

i'd definitely try interferon monotherapy or interferon+alinia+tenofovir, these drugs are active on your immune system except tnf so they cannot change or boost virus

in any case dont worry about hbvdna at 24 or 179 the difference is non significant conisdering you are not on antivirals

[manmadan]

hbv dna  179 IU/ML

Viruse started increasing

[manmadan]

i got the ast/alt results---- normal.
hbeag negative
lft normal
on saturday will get the hbvdna result

[stef2011]

unfortunately your virus is different from ours and has very little studies since rare, the hbsag mutants maybe even different one from the other and act in a different way

what about using biopsy and counting cccdna directly in the liver, this may be the best way to know how the situation is, cccdna count is the best tool, especially in ur case

[kc00]

@manmadan,,, l don't think its because of Alinia the Virus went up. Just be calm , be in touch with your doctor and listen to advice on the forum also. You will be fine. We shall all die one day with or without Hbv,earth is not a permanent place. I was scare at first but now **** the virus.shall do my treatment, and wait for miracle. Alinia reduced the virus on me meaning its working so its cant increase your virus guess something else,pls find that out. Best of luck

[manmadan]

No i have taken vaccine in feb only as per my previous chat.
I have given test for hbv dna and alt/ast also. wil get results this week end only.
I was shocked abt this result and i am little bit confused because of alinia viruse gone up /?

[stef2011]

did you take vaccine too?

it is very difficult to understand what is going on, maybe you suppressed the mutated hbsag and returned to the production of the wild type, it is impossible to say because we have no tests to see.
what about hbvdna and alt/ast?

at this point you can try only interferon when hbsag decreases again since interferon works on low hbsag less than 1500iu/ml, on higher values like 3000 nd more it owers hbsag on some but eradication is extremely rare

the other option might be gcmaf if somebody tries it and it works, maybe i wll try it

[manmadan]

hi stefano,

my latest report
hbsag 15560 iu/ml
antihbs 220iu/l

I am more worried about this huge increase. I stopped alinia too last week before.
Totally confused....with in short one month 5 times viral load increase!!!!!!!!
pl. help

[stef2011]

from HbsAg - 2650 IU/ml to 2945 iu/ml
this little increase probably the vaccine

if you happen to have the hbsag mutant the virus is probably weaker than the wildtype and both interferon and nitazoxanide are more effective, their combo is best.this is from clinical cases of hbsag mutants after lamivudine therapy, after muattion interferon was started and hbv eradicated