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Avatar universal

nucs peg add on combo with 100% response and 91% hbsag loss

this was posted already but it is better to enhance this data for all members and for all readers and keep this thread up all the time and separated

baseline hbsag<1000iu/ml has 100% response and 91% hbsag loss

http://medicalxpress.com/news/2014-04-optimal-combination-therapy-chronic-hepatitis.html
179 Responses
Avatar universal
My qHBSAG is above 52000 IU/ml...
Avatar universal
my qHBsAg is above 65000 Iu/ml aslo...
Avatar universal
my qHBsAg is above 65000 Iu/ml aslo...
Avatar universal
We all will have probably the same fate as hep c carriers. That;s how they are getting cured, and I hope will work for us as well, finger crossed, good sign
Avatar universal
after 5 to 10 years of most potent tdf or etv most patients have low hbsag, if not 1000iu/ml at least in the range of response....just a matter of time to reach lower values while on treatment
Avatar universal
How does your doctor comment about your high level of qHBSAG?
Avatar universal
nothing , just keep Nucs ON ...
Avatar universal
and he is right we know nucs lower intrahepatic hbvdna and cccdna close to 100% by 5-10years (no effects in less than 5 years), of course the most potent like tdf the better over the weaker antivirals like etv and ban of wealest like adv, lam and so on

cd8 will recover functionality and pegg add on will restore nk cells to to clear hbv

it is all studied, proven and easy, just be patient and results will come
Avatar universal
I could not imagine what I do if you were not here Steff. Because doctors do not explain the situation and tend to not telling anything about current and future status of us. Thanks for your efforts.

Avatar universal
let's keep this theard always first page, this is the most researched info for all hbvers
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d
Avatar universal
I agree Steff because it's our cure, and letting know for new members here
Avatar universal
Forgot to say that this research done by my medical center (University of Ankara). I think I am one of the patients mentioned in the research :) However, my doctor is not the research presenter doctor.
Avatar universal
Turkey has excellent medication fields, a lot of Turkey's doctors are well-known around the world. Here in New York we have one of the best Turkish American surgeon, Dr Mehmet Oz
Avatar universal
they knew all that 10 years ago that combo therapy works best. This is no new news.

I can believe, how slow the process with HBV treatment is. Still beating the same dead horse.

Where is gene therapy to knock out viruses? Where are immune system modification therapies?
Avatar universal
be optimist viran b  at least there are now drugs wich permit us to avoid liver damage for a long time,may be in the near future there will be a cure like the one for hep c developped recently,and this combo permit to many patients to be cured
Avatar universal
http://www.hepb.org/french/living_w_hepb.html
Avatar universal
Mehmet Oz is a showman rather than doctor :)

He always talks about how to live healthy rather than a cure of any illness.
Avatar universal
I totally agree with you. This is not a new news. We need more.
Avatar universal
http://www.hepatites.net/index.php?name ... mp;t=22654
Avatar universal
Hello Steff,

I read some researches that interferon does not work well in patients with HBEAG negative.

Before ETV treatment (6 months ago) I was HBEAG positive, but one month ago my HBEAG became negative and ALT flared from 90 to 330 (I do not know about ANTI-HBE status).

Does it mean that Interferon does not work for me? What do you think?  
Avatar universal
you have all the answers reading the research above.do not read around on the internet and do not read anything older than 2012 and which is not sequential treatment because wrong and obsolete by now

nothing work without sequential, pegintf monotherapy is 7-11% hbsag clearance, this is nothing when off therapy hbsag clearance is about 4% per year
Avatar universal
SafiSifa, you just said that your doctor do not explains about this disease. I noticed something in this forum that almost all members have the same problem. Do you know what? my opinion, as the Steff says do not look the old posts, because the new news are coming out and even many doctors are not aware, so they are afraid to talk with patients about anything they don't know. I had last week my visit,and even though my doctor is a professor of liver, he wasn't aware for the latest news of international liver conference. I showed the link that Steff posted, and he became very optimistic. He said: yes soon will be the same thing as for hep C.
Avatar universal
So, I think in my case,my doctor is absolutely excellent,but they are very busy with patients and they don't see every month every update, We all have to be careful and to collaborate with our doctors. Thanks god today we have all tools to keep ourself updated through internet. This is my message to you all. We should be happy because at least things have changed,we are not living as 10 years ago where it was only lamiv. we have more chances to be cured: keep in mind vitd3 and sequential treatment the thread above.
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