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superinteresting monoclonal antibody study VIR-3434

https://clinicaltrials.gov/ct2/show/NCT04423393#contacts

this monoclonal antibody presnts hbsag to tcells and dendritic cells so we can get durability of hbsag results, it is very early but if higher/longer doses are safe this could be hbv cure for low hbsag patients in combination with other drugs.a single low dose 6-18mg got 1-1.5logs reductions
https://www.natap.org/2021/EASL/EASL_43.htm

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Avatar universal
interesting update on combination trials https://www.youtube.com/watch?v=T0yqnb86Azk
Helpful - 0
9624973 tn?1413016130
It's great that is available in England. I will research more into it, although I wished the trial would be more advanced than phase 1. I don't really have the courage to enter a trial that just started out. I don't see any exclusion criteria based on being on/off nucs. So technically I would qualify even if I'm on tenofovir.
Unfortunately, the market isn't there for HBV. Based on stock advisors that report on pharmaceutical companies, it would be more like 2029 until we have something good... but I really hope they're wrong on this.
Helpful - 0
1 Comments
there s also a combination of this antibody plus rna i, they say  phase 2 here:
https://ichgcp.net/clinical-trials-registry/NCT04856085

but yes maybe better wait for more data on longer/higher doses
Avatar universal
About VIR-3434
VIR-3434 is an investigational subcutaneously administered HBV-neutralizing monoclonal antibody designed to block entry of all 10 genotypes of HBV into hepatocytes and also to reduce the level of virions and subviral particles in the blood. VIR-3434, which incorporates Xencor’s Xtend™ and other Fc technologies, has been engineered to potentially function as a T cell vaccine against HBV in infected patients, as well as to have an extended half-life
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Avatar universal
too bad no trials in my country, until now few low grade side effects

Contacts
Contact: Study Inquiry 415-654-5281

Locations
Germany
Investigative Site Not yet recruiting
Essen, Germany, 45122
Investigative Site Recruiting
Frankfurt, Germany, 60590
Investigative Site Recruiting
Hannover, Germany, 30625
Investigative Site Recruiting
Leipzig, Germany, 04103
Investigative Site Not yet recruiting
Mainz, Germany, 55131
Investigative Site Recruiting
Mannheim, Germany, 68167
Investigative Site Not yet recruiting
Ulm, Germany, 89081
Hong Kong
Investigative Site Recruiting
Hong Kong, Hong Kong

Korea, Republic of
Investigative Site Recruiting
Busan, Korea, Republic of, 47392
Investigative Site Recruiting
Busan, Korea, Republic of, 49241
Investigative Site Recruiting
Seoul, Korea, Republic of, 02841
Investigative Site Recruiting
Seoul, Korea, Republic of, 03080
Investigative Site Recruiting
Seoul, Korea, Republic of, 05505
Investigative Site Recruiting
Seoul, Korea, Republic of, 06273

New Zealand
Investigative Site Recruiting
Auckland, New Zealand, 1010
Investigative Site Recruiting
Havelock North, New Zealand, 4130
Investigative Site Recruiting
Tauranga, New Zealand, 3110
Investigative Site Recruiting
Wellington, New Zealand, 6021

Singapore
Investigative Site Recruiting
Singapore, Singapore, 169608
Investigative Site Recruiting
Singapore, Singapore, 529889

United Kingdom
Investigative Site Not yet recruiting
Birmingham, United Kingdom, B15 2GW
Investigative Site Recruiting
London, United Kingdom, E1 1FR
Investigative Site Recruiting
London, United Kingdom, SE5 9RS
Investigative Site Recruiting
Manchester, United Kingdom, M8 5RB
Sponsors and Collaborators
Vir Biotechnology, Inc.
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