superinteresting monoclonal antibody study VIR-3434

[stef2011]

https://clinicaltrials.gov/ct2/show/NCT04423393#contacts

this monoclonal antibody presnts hbsag to tcells and dendritic cells so we can get durability of hbsag results, it is very early but if higher/longer doses are safe this could be hbv cure for low hbsag patients in combination with other drugs.a single low dose 6-18mg got 1-1.5logs reductions
https://www.natap.org/2021/EASL/EASL_43.htm

[stef2011]

interesting update on combination trials https://www.youtube.com/watch?v=T0yqnb86Azk

[melcul]

It's great that is available in England. I will research more into it, although I wished the trial would be more advanced than phase 1. I don't really have the courage to enter a trial that just started out. I don't see any exclusion criteria based on being on/off nucs. So technically I would qualify even if I'm on tenofovir.
Unfortunately, the market isn't there for HBV. Based on stock advisors that report on pharmaceutical companies, it would be more like 2029 until we have something good... but I really hope they're wrong on this.

[stef2011]

there s also a combination of this antibody plus rna i, they say  phase 2 here:
https://ichgcp.net/clinical-trials-registry/NCT04856085

but yes maybe better wait for more data on longer/higher doses

[stef2011]

About VIR-3434
VIR-3434 is an investigational subcutaneously administered HBV-neutralizing monoclonal antibody designed to block entry of all 10 genotypes of HBV into hepatocytes and also to reduce the level of virions and subviral particles in the blood. VIR-3434, which incorporates Xencor’s Xtend™ and other Fc technologies, has been engineered to potentially function as a T cell vaccine against HBV in infected patients, as well as to have an extended half-life

[stef2011]

too bad no trials in my country, until now few low grade side effects

Contacts
Contact: Study Inquiry 415-654-5281

Locations
Germany
Investigative Site Not yet recruiting
Essen, Germany, 45122
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Frankfurt, Germany, 60590
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Hannover, Germany, 30625
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Leipzig, Germany, 04103
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Mainz, Germany, 55131
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Mannheim, Germany, 68167
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Ulm, Germany, 89081
Hong Kong
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Hong Kong, Hong Kong

Korea, Republic of
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Busan, Korea, Republic of, 47392
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Busan, Korea, Republic of, 49241
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Seoul, Korea, Republic of, 02841
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Seoul, Korea, Republic of, 03080
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Seoul, Korea, Republic of, 05505
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Seoul, Korea, Republic of, 06273

New Zealand
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Auckland, New Zealand, 1010
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Havelock North, New Zealand, 4130
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Tauranga, New Zealand, 3110
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Wellington, New Zealand, 6021

Singapore
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Singapore, Singapore, 169608
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Singapore, Singapore, 529889

United Kingdom
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Birmingham, United Kingdom, B15 2GW
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London, United Kingdom, E1 1FR
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London, United Kingdom, SE5 9RS
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Manchester, United Kingdom, M8 5RB
Sponsors and Collaborators
Vir Biotechnology, Inc.