Aa
swelling on face
Hello ,i m taking tdf more than 10 months,now days i m feeling swelling on my face mostly on left side,is it normal
I am not a doctor. From what I can gather from your previous posts, you have provided only some details about your HBV infection. Let me recap:
1. You were put on TDF in March 2016, when you hbvdna was 2800 iu/ml, LFTS normal; in 2014, your hbvdna was 133 iu/ml.
2. You became pregnant whilst on TDF, but very sadly at week 22, you had a miscarriage.
3. You have depression and constant worry about your losing your kidney due to TDF
4. Now you have swelling on your face.
5. You want to stop TDF, maybe try IFN, also also you want to have an baby.
From your history, you were put on TDF in March 2016. Were you on any treatment before that?
You are right, normally with hbvdna at 2800 iu/ml and normal ALT, you can observe before starting treatment, unless (just guessing here)
1. You were on other antiviral, reducing your viral load to 133, then a rise to 2800 iu/ml was detected. Your doctor suspected drug resistance and therefore switching to TDF; or
2. You were inactive HBeAg negative, with low hbvdna, then your hbvdna increased to 2800 iu/ml. Fearing that you are developing chronic HBeAg negative Hepatitis, you doctor decided to treat.
From clinical studies, TDF is safe. Some patients will experience a decrease in Kidney functions, but will then stabilize without further deterioration in Kidney function. Face swelling is not a commonly known side effect of TDF, however it should be investigated to determine the cause. Depression is common after pregnancy and in HBF patients, it should be treated.
IFN is for at least 48 weeks, it can have very serious side effects. You cannot fall pregnant until at least 6 months after IFN treatment. Whether IFN treatment will be successful, depends on many factors which she have not stated.
As for stopping TDF satfely, it again depends on many factors: your
HBVDNA, ALT, serum HBsAg quantity, and also the state of your liver (degree of fibrosis).
Best
1. You were put on TDF in March 2016, when you hbvdna was 2800 iu/ml, LFTS normal; in 2014, your hbvdna was 133 iu/ml.
2. You became pregnant whilst on TDF, but very sadly at week 22, you had a miscarriage.
3. You have depression and constant worry about your losing your kidney due to TDF
4. Now you have swelling on your face.
5. You want to stop TDF, maybe try IFN, also also you want to have an baby.
From your history, you were put on TDF in March 2016. Were you on any treatment before that?
You are right, normally with hbvdna at 2800 iu/ml and normal ALT, you can observe before starting treatment, unless (just guessing here)
1. You were on other antiviral, reducing your viral load to 133, then a rise to 2800 iu/ml was detected. Your doctor suspected drug resistance and therefore switching to TDF; or
2. You were inactive HBeAg negative, with low hbvdna, then your hbvdna increased to 2800 iu/ml. Fearing that you are developing chronic HBeAg negative Hepatitis, you doctor decided to treat.
From clinical studies, TDF is safe. Some patients will experience a decrease in Kidney functions, but will then stabilize without further deterioration in Kidney function. Face swelling is not a commonly known side effect of TDF, however it should be investigated to determine the cause. Depression is common after pregnancy and in HBF patients, it should be treated.
IFN is for at least 48 weeks, it can have very serious side effects. You cannot fall pregnant until at least 6 months after IFN treatment. Whether IFN treatment will be successful, depends on many factors which she have not stated.
As for stopping TDF satfely, it again depends on many factors: your
HBVDNA, ALT, serum HBsAg quantity, and also the state of your liver (degree of fibrosis).
Best
2 Comments
stephen i was not any treatment before,last year i force my doctor to put me on tdf he was not willing for treatment,if i stop taking tdf what will b side effects?
Stopping any treatment generally requires close monitoring by your doctor, that is, frequent testing of your hbvdna and ALT. Either you can stop safely, that is, your hbvdna will remain below 2,000 iu/ml and your ALT is normal. Or after stopping, your hbvdna will increase greatly and your ALT will also go up - in that case, you will need to consider to re-start treatment.
Generally, after stopping, your hbvdna and ALT will change (up then down, or up and stay up, etc)within a period of several months, it takes the experience of a good HBV doctor to advise you whether you can continue to stop or need to re-start. Talk to your doctor and work out a plan.
Generally, after stopping, your hbvdna and ALT will change (up then down, or up and stay up, etc)within a period of several months, it takes the experience of a good HBV doctor to advise you whether you can continue to stop or need to re-start. Talk to your doctor and work out a plan.
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