to all forum members, who as experience on liposoms?

[stef2011]

i have seen on internet some liposoms already on the market for vit c, what do you think are they real?

they should have antiviral activity both empty or with drugs, what do you think?
this is a link with lipo vitamin c but the problem is who checks if those are real liposoms?
http://www.livonlabs.com/cgi-bin/start.cgi/lypo-spheric/LSC30.html

antiviral against hepatitis B and C viruses and HIV by decreasing cholesterol levels in infected cells
http://www.bioch.ox.ac.uk/aspsite/index.asp?pageid=751

[stef2011]

i searched about this articles but there are no studies to link more vitamin b complex to improved interferon or immune system results, in any case i covered b complex by diet but i don t know my levels

i also checked iron link with insulin resistance and fatty liver, i will have my ferritin level checked tomorrow but since i eat almost no meat and don t eat high iron content foods it should be low (in my life i ve always had low ferritin and they even gave me supplements when very young it seems to be a mistake now).

tomorrow i'll have full check except hbsag (in 2 weeks there should be a new architect machine in a hospital in my city, i will wait for it instead moving to rural areas labs to make it).if alt and creatinine are low range normal i will try low dose red yeast rice to see if i can get cholesterol very low without sides and possibly with alt/creatinine lowering

[StephenCastlecrag]

Thanks. I think you cover everything except:
1. Vitamin B complex (Hepatitis B carriers seem to be low in Vitamin B, see below)
2. No excessive iron (viruses love iron, I was told)

http://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2010.02390.x/full
In conclusion, HBsAg serum levels could be the result of the complex balance between the virus and the host's immune system as well as the product of the transcription of specific mRNAs rather than viral replication. The substantial variations in total serum HBsAg during the different phases of HBV infection suggest that quantitative HBsAg could be a new diagnostic tool for characterization of the HBV carrier in combination with HBV DNA.



Chemistry and Materials Science European Journal of Nutrition
DOI: 10.1007/s00394-010-0156-1Online First™
Original Contribution

Vitamins B status and antioxidative defense in patients with chronic hepatitis B
or hepatitis C virus infection

Chun-che Lin, Wen-hu Liu, Zhi-hong Wang and Mei-chin Yin

Abstract

Background & Aims  
The impact of hepatitis B virus (HBV) or hepatitis C virus (HCV) infection upon
B vitamins status and antioxidative defense in infected patients was examined.

Methods  
Dietary record and blood levels of B vitamins and oxidative stress–associated
biomarkers were determined for 195 healthy controls, 132 HBV, and 114 HCV
patients.

Results  
HBV-infected patients had significantly higher levels of total cholesterol, free
fatty acids (FFA), and lower ghrelin level (p < 0.05); and HCV-infected patients
had significantly higher Ishak inflammation score and lactate dehydrogenase
activity (p < 0.05). HBV patients had significantly lower red blood cell (RBC)
vitamins B2 and B6 levels, and HCV infection significantly decreased vitamins
B2, B6 and folate levels in RBC and/or plasma (p < 0.05). Correlation
coefficients of RBC vitamin B2 versus serum FFA in HBV patients, RBC vitamins B2
and B6 versus HCV RNA and Ishak inflammation score, and plasma vitamin B6 vs
Ishak inflammation score in HCV patients were <−0.5. HBV-infected patients had
significantly higher oxidized glutathione level and lower glutathione peroxidase
activity (p < 0.05), but HCV patients had significantly lower superoxide
dismutase and catalase activities (p < 0.05).

Conclusion  
HBV or HCV infection enhanced oxidative stress and lowered B vitamins in
circulation. In order to avoid other healthy risk, nutrition status should be
monitored and limitation or supplementation of certain nutrients might be
helpful for HBV- or HCV-infected patients

[stef2011]

thank for your help, this liposome thing is very confusing, they are very old substances very used in antiage creams since decades, no patents and no high cost, also making liposomes is extremely easy but when searching for it on internet everything is confusing.probably there is no much intrest for drug makers

i have seen forums where people have home machines to do liposomes for vitamins so making empty liposomes shouldn t be difficult and there should be also no sides on pure empty liposomes.if you have time please you check google on this too

dinavax vaccine and dentric cell therapy used for cancer might do the trick of keeping immune system active while under nucs, but the frst is not yet available and the second is only made in some cancer hospitals but for cancer not for hbv.a russian researcher did it on hbv and suggested it since it is made on cancer from many years

we can also help immune response keeping cholesterol and glucose very low because these envelopped viruses feed themselves from these two, also keeping low wheight/low bmi helps very much.
of course we need also alinia and interferon in this strategy because immune system alone can t do nothing until there is this big load of hbsag suppressing it

in any case all factors associated with higher seroconversions on immune modulators are  low weight, low bmi, low lipids, low glucose, no insulin resistance, no fat in the liver, higher vitamin d which is negatively correlated to all previous factors.higher fat reduces also the quantity of drugs in tissues and makes more inflammation and sides effects

[StephenCastlecrag]

Thank you for giving me all the references regarding cholesterol and Hepatitis B.

I google about liposomes, did not get very far. It seems you have to use PERL (see blow) and have no idea whether these are available as products. Anyhow, this provides another approach to attacking HBV through targeting the host cells rather than the virus.

You seem to think existing antivirals lower hbvdna only, but it also lowers the immune system. I see it differently. After the amount of hbvdna is lowered, it is natural that the immune response will also be lowered as there are fewer viruses(I am not sure if this is correct). So the trick must be to lower hbvdna and at the same time maintain the same level of immune response (?).

I am still not clear about the relationship between amounts of Hbsag, virons (full virus particles) and hbvdna in the blood.

Abstract
The pressing need for broad-spectrum antivirals could be met by targeting host rather than viral processes. Cholesterol biosynthesis within the infected cell is one promising target for a large number of viral systems, including hepatitis C virus (HCV), hepatitis B virus (HBV) and HIV. Liposomes developed for intracellular, endoplasmic reticulum (ER)-targeted in vivo drug delivery have been modified to include polyunsaturated fatty acids that exert an independent antiviral activity through the reduction of cellular cholesterol. These polyunsaturated ER liposomes (PERLs) have greater activity than lovastatin (Mevacor, Altoprev), which is clinically approved for lowering cholesterol and preventing cardiovascular disease. Treatment of HCV, HBV, and HIV infections with PERLs significantly decreased viral secretion and infectivity, and pretreatment of naïve cells reduced the ability of both HCV and HIV to establish infections because of the decreased levels of plasma membrane cholesterol. Direct competition for cellular receptors was an added effect of PERLs against HCV infections. The greatest antiviral activity in all three systems was the inhibition of viral infectivity through the reduction of virus-associated cholesterol. Our study demonstrates that PERLs are a broadly effective antiviral therapy and should be developed further in combination with encapsulated drug mixtures for enhanced in vivo efficacy.