vit d3 82ng/ml and lowering alt, not on therapy

[stef2011]

my sister just got tests results and the patern of hbvdna, alt looks inversely correlated with vitd 25oh>80ng/ml, this can be confirmed by time, she now has for the first time alt 40, hbvdna stable at around 200.000iu/ml, no liver damage 4.5kpa, hbsag around 18.000iu/ml

probably vitamin d is able to protect liver despite hbvdna detactable keeping alt 40, she will be checking fibroscan and hbsag next month

she has normal calcium as usual and creatinine and check every 3 months with vit d.she has daily vit d3 5000-8000iu

[4est]

as I was google for HDL - HVB DNA relation (still not found EASL report) i was came across the flowing articles:
http://www.theheart.org/article/1174743.do
and
http://www.telegraph.co.uk/health/healthnews/8267570/Millions-taking-statins-needlessly.html
and even if they are not direct related to HBV, I think is good to be mentioned for people that use statin

[stef2011]

Serum 25-Hydroxyvitamin D and the Incidence of Acute Viral Respiratory Tract Infections in Healthy Adults

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0011088

chart of illness according to vit d levels:
many many sick patients vit d below 50ng/ml
4 patients with vit d levels between 50-70ng/ml
no sick patients d levels over 75ng/ml


http://www.plosone.org/article/slideshow.action?uri=info:doi/10.1371/journal.pone.0011088&imageURI=info:doi/10.1371/journal.pone.0011088.g002

Conclusions

The data in this study suggests that supplementing with vitamin D to raise the concentrations in the general population to above 38 ng/ml could result in a significant health benefit by reducing the burden of illness from viral infections, at a minimum from viral infections of the respiratory tract in healthy adults living in temperate climates. Our findings may provide direction for and call for future interventional studies examining the efficacy of vitamin D supplementation in reducing the incidence and severity of specific viral infections, including influenza, in the general population and in specific subpopulations, such as pregnant women, dark skinned individuals, and the obese.

[stef2011]

that disinformation is going on since it was rejected patent to vit d because there are too many diseases prevented thus too many loss on drug industry

in this story they produced vit d2 which is not natural and was patented but this vit d2 has toxicity, sides effect, calcemina and can t rise vit d3 in serum.......

anyway only US institutes are continuatively reporting wrong values despite tons of studies and european institutes/researchers saying opposite, this makes think of corruption in US going beyond FDA only.....even OMS has been shown to be corrupted in the swine flu story because the same persons in the OMS saying it was pandemic were paid by flu drug makers.too bad the trials for corruption started in europe are so silent and we dont even know if those persons have been charged for what they did...

[4est]

Why the IOM Recommendations for Vitamin D are Deficient - http://www.vitamindwiki.com/tiki-index.php?page_id=1330

[stef2011]

they are all wrong the dose cannot be established because we are all different, 5000iu dose may be used for healthy people with no infections/obesity only, all the others needs to measure vit d and calcium and increase or lower doses according to response.
once 70-90ng/ml are reached the dose can be slowly decreased to 7000iu and then 5000iu to see what can keep levels at that range.

for me only 10.000iu daily can reach 69ng/ml, for my sister 80ng/ml, at 5000iu we get lower than 50ng/ml.so it must be personalized to reach the correct levels.

[4est]

I agree that levels have to be >40 or 60 -100 ... but the questions is if is OK to go with 5000 UI and reach this levels in a short time or is OK to go with 2000 UI and reach this levels in a longer time. - I think this is the question - how is the best way to reach the levels fast and high UI or slow and low UI.

[4est]

some other sites say that 3000 - 5000 UI is OK - http://www.vitamindcouncil.org/about-vitamin-d/how-to-get-your-vitamin-d/vitamin-d-supplementation/

on the vitamin D the recomandation are not clear yet.

[stef2011]

no vit d dose can dmaage liver until 20000iu daily with normal calcium, just look at trials on people with hbv or hcv or liver diaseases

there are tons of disinformation with no human trials or study to prove vitamin d can have any toxicity while we do have studies that show antiviral effect and protection of liver and regression of liver damage by vit d.so obviously it cannot be toxic but the contrary

the levels must be 60-100ng/ml with normal calcium

[stef2011]

vitamin a is bad for hbv and not necessary, only d is necessary.betacarotene is a precursor of vit a, this is not toxic at any dose but again not nedded on hbv

C and E may help recover liver damage  and oxidative stress but no immune system/antiviral effect like vit D

i could not find that study that measured also high titers of hdl like 60-90mg/dl which are not common.anyway even older studies linked high hbvdna with low hdl

[grmr]

does this mean even 5000iu/daily can harm the liver??

[4est]

http://www.iom.edu/Reports/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D.aspx - new guidelines for vitamin D by IOM

[4est]

folowing link is related to HCV but also with vit D and interferon (look for What about vitamin D ? section)

http://hepatitiscnewdrugs.blogspot.com/2012/01/hepatitis-c-and-liver-health-getting-it.html

- what i don't understand is the "opposite" opinion:
1. Mega-vitamin supplements, particularly if they contain vitamins A and D, may be harmful. Excess vitamin A is very toxic to the liver.

2. The Bottom Line: Vitamin D3 may have a significant impact on HCV and treatment for it.

or maybe is just about the quantity of D supplements.

on the other hand (regarding other vitamin) they say:
"Based on the conducted randomised clinical trials, convincing evidence that beta-carotene, vitamin A, vitamin C, and vitamin E or their combinations are beneficial for treatment of alcoholic, autoimmune, hepatitis B or hepatitis C virus liver diseases, or liver cirrhosis could not be found."

[4est]

thanks for the general link. I will look for the hdl presentation for more details (I spend some time, but not found it yet :) )

[stef2011]

finally after googling about 2 hrs found the link of posters about easl 2011 berlin, the study is among these abstracts

http://www1.easl.eu/easl2011/program/Posters/index.asp

[stef2011]

not the study at easl which considered also good hdl ranges superior to 70mg/dlbut about hdl
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949833/

[stef2011]

http://www2.kenes.com/liver-congress/Pages/Previous_Congresses.aspx

[stef2011]

i ll check them all later anyway since we have access to full studies now and it can be interesting to see full study of some

[stef2011]

i posted already here it was easl 2010 or 2011, i can t find it by search box now.it was something simialr to vit d abstarct, those with lowest hbvdna have high hdl

here's webcasts link but we have to search again all both 2010 and 2011
http://www.multiwebcast.com/easl/2011/International_Liver_Congress_2011/listing_poster/by_poster#_t_192

[4est]

"we do know hdl is antiviral on hbv from a study presented at easl 2010 or 2011, ... " - do you have the link to this study ? (I had a quick look but not found )

[4est]

also nowfood has 5000 iu vit d 3

http://www.nowfoods.com/Supplements/Products-by-Category/Vitamins/Vitamin-D/M103118.htm

[stef2011]

for those interested i have found the following in capsules:

puritans.com
vit d3 5000iu capsules

http://www.biotechpharmacal.com/
vit d3 in 5000iu per capsule and 50.000iu per capsules, they are with no oil so these must be taken with a meal

solgar.com
solgar d3 5000iu capsules

i have found these good prices and products online online, at pharmacies the products are expensive, with ridiculous d3 quantity

[brij116]

Yes, I bought it localy. But no body understands vitd3 in India. I checked with many medical stores. But they always said that there are no vitd3 tablets or capsuls availble and it comes only with Calcium. Finally, I asked for Calcirol which is a very high dose suitable for weekly and monthly  schedule only. Along with this weekly/montly dose , I had been taking shelcal-HD (calcium + Vitd3 500IU) daily as a maitainance dose.

Now, I have procured vitd3 through net and stopped Shelcal-HD following Stef's advice. However, I will continue with following schedule for next 6 months:
Calcirol (vit d3-60,000IU) - 1/month +
Vit d3 Capsules (2000-IU) - 1/day
Addtional 1000-IU per day I will manage with milk, egg and Sun. I have also been getting sunrays for 30-45 min everday during 12;00pm to 2:00pm

As far as I know, Vit d3 is insoulble in water. I have been taking Calcirol, which is in powdery form with a cup of milk . Vit d3 is soluble in milk.

[grmr]

i do believe softgels have got some oil into their compositiion

[stef2011]

by the way remember that vit d3 absorption can be boosted by oliv oil or fish oil and that capsules with oils are better.
it is also better to take capsules during meals