Aa
Could microglia eradication provide relieve for this hell?
There's this new drug currently in phase 1b or 2
It's called plx3379
It destroys the IFN induced chronic activity of the microglia, by killing the microglia itself.
After a week of cessation of treatment the microglia grew newly and insensitive.
Couldn't that provide a solution to this HELL post IFN?
Ah, the stuff has side effects but they gave it to end stage tumor patients for about 250 days in doses of 1000mg / d
I suggest that some weeks taking this stuff could substantially improve brain functioning, by "resetting" the microglia
It's called plx3379
It destroys the IFN induced chronic activity of the microglia, by killing the microglia itself.
After a week of cessation of treatment the microglia grew newly and insensitive.
Couldn't that provide a solution to this HELL post IFN?
Ah, the stuff has side effects but they gave it to end stage tumor patients for about 250 days in doses of 1000mg / d
I suggest that some weeks taking this stuff could substantially improve brain functioning, by "resetting" the microglia
http://www.ncbi.nlm.nih.gov/pubmed/25674053
Minocycline,an antibiotic-have a read xxx
Minocycline,an antibiotic-have a read xxx
1 Comments
"These results suggest that microglial activation plays a critical role in the development of IFN-α-induced depression,"
Ok, i recently found an article that explained the calculation of mouse-to-human doses and to my sursprise my calculations for an adequate dose were false by the factor 20.
I calculated:
290mg per kilo in mice
that means 20300mg in humans (70kg)
there is something called the BSA which is the overall body surface area.
one has to multiply the mice dose with 3 and divide the result with 37.
that means in the end:
1600mg per day in humans (70kg)
that is amazing since it shortens the treatment time from over 6 months to only 21 days!
i don't know if this will fix the neuronal issues but i will go this way and if it doesn't work who cares!
I calculated:
290mg per kilo in mice
that means 20300mg in humans (70kg)
there is something called the BSA which is the overall body surface area.
one has to multiply the mice dose with 3 and divide the result with 37.
that means in the end:
1600mg per day in humans (70kg)
that is amazing since it shortens the treatment time from over 6 months to only 21 days!
i don't know if this will fix the neuronal issues but i will go this way and if it doesn't work who cares!
ok the memoriial sloan cancer center or what it is called replied that it would be better to make a telephone contact to one of their physicians, i'll do it this week i guess. today i took a little bit of amphetamine an hour ago but the fatigue still is present. took 2 tablets of ALA with it...
today is such a worthless day, the people i'm locked up with told me how awesome rollercoaster rides are and that one of them faked seizures, i don't care.
my mother was here some days ago, i was allowed 30 min a day to walk outside (after 3 months of complete lockdown),
daily struggling to keep the eye on the positive, hope is a word, i have to get rid of the Wellbutrin which makes me weird, i don't know how to obtain 33.000 euro, i don't know if the meds will cure this state, i don't know what the future is doing to me.
still standing up everytime i lose myself, still hoping everything will get back to normal. suicide is the last project and i still have other projects before it gets to the last one. so if the projects don't show any improvement i have at least an exit ticket.
but that's future
today is such a worthless day, the people i'm locked up with told me how awesome rollercoaster rides are and that one of them faked seizures, i don't care.
my mother was here some days ago, i was allowed 30 min a day to walk outside (after 3 months of complete lockdown),
daily struggling to keep the eye on the positive, hope is a word, i have to get rid of the Wellbutrin which makes me weird, i don't know how to obtain 33.000 euro, i don't know if the meds will cure this state, i don't know what the future is doing to me.
still standing up everytime i lose myself, still hoping everything will get back to normal. suicide is the last project and i still have other projects before it gets to the last one. so if the projects don't show any improvement i have at least an exit ticket.
but that's future
thanks,
i looked up that it's scheduled for 2019 when phase3 trials end.
i guess i have to wait unless mr tap signals no danger going on with this new kid on the block.... i'll keep u updated
i looked up that it's scheduled for 2019 when phase3 trials end.
i guess i have to wait unless mr tap signals no danger going on with this new kid on the block.... i'll keep u updated
sorry to get amount of time wrong.........your determination to find
a solution is impressive.....Thank you for posting and all the best
to all of us in the quest for health..
a solution is impressive.....Thank you for posting and all the best
to all of us in the quest for health..
ok, mister Green wasn't impressed by the idea because he only did his surveys on mice.. analyzed their brains etc.
i wrote to another doctor who is actually treating people with the drug.
and i asked him for severe, irreversible side effects that maybe show up.
(i*m extremely careful since IFN), so the drug is in PHASE III for tumors,
how long does it take until it hits markets? it already has orphan drug status in US and EU
i wrote to another doctor who is actually treating people with the drug.
and i asked him for severe, irreversible side effects that maybe show up.
(i*m extremely careful since IFN), so the drug is in PHASE III for tumors,
how long does it take until it hits markets? it already has orphan drug status in US and EU
Hang in there .....you will turn this thing around and there have been
improvements ....you show great determination and intelligence in
searching out a solution. Six months is early days......I understand
your anger fully.
improvements ....you show great determination and intelligence in
searching out a solution. Six months is early days......I understand
your anger fully.
i want to slap my doctor.
he prescribed IFN to a 25 year old at the time with F0 zero liver scars, 1 month before Harvoni hit the markets.
this cannot be true THIS CANNOT BE TRUE THERE HAS TO BE AN OTHER LIVE
I THINK WHEN I DIE THAT EVERYTHING WILL TURN AROUnD AND THAT I CAN START AGAIN FROM THE BEGINNING WITH A FRESH NEW BRAIN HAHA!!!!!!!!!!!!! UNTIL I DIE
he prescribed IFN to a 25 year old at the time with F0 zero liver scars, 1 month before Harvoni hit the markets.
this cannot be true THIS CANNOT BE TRUE THERE HAS TO BE AN OTHER LIVE
I THINK WHEN I DIE THAT EVERYTHING WILL TURN AROUnD AND THAT I CAN START AGAIN FROM THE BEGINNING WITH A FRESH NEW BRAIN HAHA!!!!!!!!!!!!! UNTIL I DIE
can you be productive?
i can't. A **** did happen since i did interferon. Yes, the meds help, yes my memory improved a bit, yes i can have a better sleep.
but my essence is gone. i developed intolerances against ****** everything.
it's a war, every ****** day, every week, every month and i guess every year until i die.
that's fate.
i can't. A **** did happen since i did interferon. Yes, the meds help, yes my memory improved a bit, yes i can have a better sleep.
but my essence is gone. i developed intolerances against ****** everything.
it's a war, every ****** day, every week, every month and i guess every year until i die.
that's fate.
I have been reading your latest posts. It sounds like you have made major improvement in your recovery over the last 6 month. You were very concern that you mind had been taken away from you. We told you it does take time to recover. I had the same experience and have recovered. Honestly,
you sound like you have progressed to being yourself again. It might benefit you to go back and read your first post. It does sound like your a totally different person.
Many people experience this from hepatitis C treatment. More so, from interferon. Some have lasting effects from drug therapies. I don't see that you are one of those people.
Sounds like you have been cured and doing well. And can return to you
life before all this stopped you from living a productive life.
Congratulations
you sound like you have progressed to being yourself again. It might benefit you to go back and read your first post. It does sound like your a totally different person.
Many people experience this from hepatitis C treatment. More so, from interferon. Some have lasting effects from drug therapies. I don't see that you are one of those people.
Sounds like you have been cured and doing well. And can return to you
life before all this stopped you from living a productive life.
Congratulations
maybe flawed in one way but he is correct that under very controlled lab conditions vs real world conditions. You should understand this.
I am glad that you communicated with the head of the lab and that he responded. Please do take his advice!
I am glad that you communicated with the head of the lab and that he responded. Please do take his advice!
Ok, i had a discussion with the head of the lab that is researching PLX3397 and he told me that it's a very bad idea to take the agent on my own due to unknown side effects and that it could make everything worse.
i was pretty sad because it sounded like such a good idea to renew the microgl. but as i read his lines he wasn't really impressed.
"All our experiments are performed on mice in sterile vivariums, where they are not exposed to the same pathogens as humans out in the world. We do not know the effects in humans, and it could easily kill off the non-primed microglia preferentially, plus any number of other toxicities around the body"
i think he thought that i want to take the same dose as the mice (20 grams a day) but this is a misunderstanding. i keep you updated. it's hard to write to such people with such a flawed mind.....................
i was pretty sad because it sounded like such a good idea to renew the microgl. but as i read his lines he wasn't really impressed.
"All our experiments are performed on mice in sterile vivariums, where they are not exposed to the same pathogens as humans out in the world. We do not know the effects in humans, and it could easily kill off the non-primed microglia preferentially, plus any number of other toxicities around the body"
i think he thought that i want to take the same dose as the mice (20 grams a day) but this is a misunderstanding. i keep you updated. it's hard to write to such people with such a flawed mind.....................
here's an exp. about a similar drug.
While on Sorafenib I traveled within the US and abroad and worked pretty much full time. Everyone's experience is going to differ but I was not too bad off. (This goes for the other drugs i've been on as well - just living life nearly as usual).
What I remember most is sore callused feet, thinning hair, hair turning grey/white (it grew back with color once i stopped the drug), being a bit more tired than usual and having issues with diarrhea. I used an OTC med for the diarrhea (Immodium) and that worked fine. The feet soreness was the most noticeable side effect for me. I took to soaking my feet some evenings and wearing Haflinger wool shoes with gel inserts and that did help quite a bit - those shoes are not tight fitting and they have soft molded support beds which is why they were so comfy. I still tend to wear them. Not fashionable but definitely comfortable. If you live it a hot place they may not be the best choice (what with being wool...) but there are some stretchy Sketcher shoes that are also good for the soles of the feet.
It is daunting moving towards oral chemo. I went into it with trepidation but I have been fortunate to retain a high quality of life and gain some benefit and for that I am grateful. I hope that you will experience similar results. BTW, there is a yahoo group for advanced thyroid cancer if you ever feel the need to connect with people who are dealing with more complicated cases. Lots of understanding, knowledge and support there.
Best to you
eileen
While on Sorafenib I traveled within the US and abroad and worked pretty much full time. Everyone's experience is going to differ but I was not too bad off. (This goes for the other drugs i've been on as well - just living life nearly as usual).
What I remember most is sore callused feet, thinning hair, hair turning grey/white (it grew back with color once i stopped the drug), being a bit more tired than usual and having issues with diarrhea. I used an OTC med for the diarrhea (Immodium) and that worked fine. The feet soreness was the most noticeable side effect for me. I took to soaking my feet some evenings and wearing Haflinger wool shoes with gel inserts and that did help quite a bit - those shoes are not tight fitting and they have soft molded support beds which is why they were so comfy. I still tend to wear them. Not fashionable but definitely comfortable. If you live it a hot place they may not be the best choice (what with being wool...) but there are some stretchy Sketcher shoes that are also good for the soles of the feet.
It is daunting moving towards oral chemo. I went into it with trepidation but I have been fortunate to retain a high quality of life and gain some benefit and for that I am grateful. I hope that you will experience similar results. BTW, there is a yahoo group for advanced thyroid cancer if you ever feel the need to connect with people who are dealing with more complicated cases. Lots of understanding, knowledge and support there.
Best to you
eileen
and @sides a good thing is that one can lower the dose or stop treatment anytime one experiences sides getting worse.
the bad microglia isn't a virus, it just exists, has to be wiped out. regardless of the timeframe dose adjustments or treatment pause are not a problem. it's not HCV!
the bad microglia isn't a virus, it just exists, has to be wiped out. regardless of the timeframe dose adjustments or treatment pause are not a problem. it's not HCV!
and yes, it destroys the bad microglia and replaces it bit by bit by regrown microglia.
the sides come from the TKI aspect i guess, the CSF1R aspect does not have so much sides except elevations in Interleukin 34.
LDN is working great, i can do an hour of walking without being exhausted!
didn't know what i would do without it!
the sides come from the TKI aspect i guess, the CSF1R aspect does not have so much sides except elevations in Interleukin 34.
LDN is working great, i can do an hour of walking without being exhausted!
didn't know what i would do without it!
i guess it will get as bad as IFN but i saw people writing they were on other TKIs for 4 years and continued to work fulltime! so, it can't be that bad. it will get bad, i know that for shure but nothing is as bad as the situation at the moment. i cannot live this life like this anymore. on top of that i'm locked down in a mental healthcare unit since the introduction of IFN.(mental sides)
Sounds nearly as bad as Interferon ! So the idea is that it it destroys the sick
microglia and enables nice new fresh ones to grow ? I can see how that might work.....in the meantime how is LDN helping ? my sense is that you have
some improvement from it. All the best..
microglia and enables nice new fresh ones to grow ? I can see how that might work.....in the meantime how is LDN helping ? my sense is that you have
some improvement from it. All the best..
i also researched a bit about TKIs (Tyrosine Kinase Inhibitors like PLX3397)
and their side effects....
well... the studies about the agent summarize the AEs (Adverse Events)
as moderate: look at the timeframe (7 days)
38 recurrent GB(brain tumor) patients were treated with PLX3397 at 1000 mg daily, with Cohort 1 (14 patients) treated 7 days in advance of recurrent surgery and Cohort 2 (24 patients) without surgery. PLX3397 was well tolerated; common (>10%) treatment-related adverse events included fatigue, constipation, nausea, hair color change, elevation in AST/ALT, anorexia, and headache.
timeframe about 4-6months:
For the 23 enrolled patients, the most common treatment-related side effects were hair color changes, fatigue, nausea, swelling around the eyes, abnormal taste, diarrhea, vomiting, and decreased appetite. Treatment-related, severe adverse events were liver enzyme elevations, hyponatremia, anemia, fatigue, diarrhea, and neutropenia.
and their side effects....
well... the studies about the agent summarize the AEs (Adverse Events)
as moderate: look at the timeframe (7 days)
38 recurrent GB(brain tumor) patients were treated with PLX3397 at 1000 mg daily, with Cohort 1 (14 patients) treated 7 days in advance of recurrent surgery and Cohort 2 (24 patients) without surgery. PLX3397 was well tolerated; common (>10%) treatment-related adverse events included fatigue, constipation, nausea, hair color change, elevation in AST/ALT, anorexia, and headache.
timeframe about 4-6months:
For the 23 enrolled patients, the most common treatment-related side effects were hair color changes, fatigue, nausea, swelling around the eyes, abnormal taste, diarrhea, vomiting, and decreased appetite. Treatment-related, severe adverse events were liver enzyme elevations, hyponatremia, anemia, fatigue, diarrhea, and neutropenia.
since TLR4 has to be inhibited (that's what LDN does) :
Eight tricyclics were tested for effects on TLR4 signaling in HEK293 cells over-expressing human TLR4. Six exhibited mild (desipramine), moderate (mianserin, cyclobenzaprine, imiprimine, ketotifen) or strong (amitriptyline) TLR4 inhibition, and no TLR4 activation. In contrast, carbamazepine and oxcarbazepine exhibited mild and strong TLR4 activation, respectively, and no TLR4 inhibition. Amitriptyline but not carbamazepine also significantly inhibited TLR2 signaling in a comparable cell line. Live imaging of TLR4 activation in RAW264.7 cells and TLR4-dependent interleukin-1 release from BV-2 microglia revealed that amitriptyline blocked TLR4 signaling
Eight tricyclics were tested for effects on TLR4 signaling in HEK293 cells over-expressing human TLR4. Six exhibited mild (desipramine), moderate (mianserin, cyclobenzaprine, imiprimine, ketotifen) or strong (amitriptyline) TLR4 inhibition, and no TLR4 activation. In contrast, carbamazepine and oxcarbazepine exhibited mild and strong TLR4 activation, respectively, and no TLR4 inhibition. Amitriptyline but not carbamazepine also significantly inhibited TLR2 signaling in a comparable cell line. Live imaging of TLR4 activation in RAW264.7 cells and TLR4-dependent interleukin-1 release from BV-2 microglia revealed that amitriptyline blocked TLR4 signaling
Venting is certainly very healthy!
I hope to NEVER be on ADs again but what you have researched is certainly interesting!
Amitriptyline is on on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system (according to Wikipedia).
LDN does change everything agreed!
I hope to NEVER be on ADs again but what you have researched is certainly interesting!
Amitriptyline is on on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system (according to Wikipedia).
LDN does change everything agreed!
ok. weird mode. i have to vent.
thanks, what TEMPORARY helps with memory, cognitive issues are stimulants like MPH, Amphetamine based Antidepressants, stimulants though one has to be very careful to not overdo them and upregulate inflammation as a side effect. I take ALA to deal with the free radicals that the microglia spits out, but i'm often too weak to think about it, remember it and so on. I get Bupropion at the highest dose available (300mg) but i struggle with it somehow... i got some MPH an hour ago and did about 80mg (40 unret. 40 ret.) to get some energy to clean up my bedroom cause my mum plans to get here tomorrow.
it's always a give and get... get energy, loose memory... my psych drugs should get changed... since the LDN reduced inflammation, stimulant drugs seem to flare it up in a way and crashes are programmed... i*m much more weird on stimulants than without... my doc is in it*s holiday and their assistant didn't want to change anything on the Antidepressive medication.
i plan to step down a bit and get on Amitriptyline, it*s an Antidepressant and reduces inflammation as a side effect.
The project will start as soon as i am on a stable regimen and not think and act like a computer with a virus (like today), i gues i start in about 6-8 weeks.
thanks, what TEMPORARY helps with memory, cognitive issues are stimulants like MPH, Amphetamine based Antidepressants, stimulants though one has to be very careful to not overdo them and upregulate inflammation as a side effect. I take ALA to deal with the free radicals that the microglia spits out, but i'm often too weak to think about it, remember it and so on. I get Bupropion at the highest dose available (300mg) but i struggle with it somehow... i got some MPH an hour ago and did about 80mg (40 unret. 40 ret.) to get some energy to clean up my bedroom cause my mum plans to get here tomorrow.
it's always a give and get... get energy, loose memory... my psych drugs should get changed... since the LDN reduced inflammation, stimulant drugs seem to flare it up in a way and crashes are programmed... i*m much more weird on stimulants than without... my doc is in it*s holiday and their assistant didn't want to change anything on the Antidepressive medication.
i plan to step down a bit and get on Amitriptyline, it*s an Antidepressant and reduces inflammation as a side effect.
The project will start as soon as i am on a stable regimen and not think and act like a computer with a virus (like today), i gues i start in about 6-8 weeks.
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