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883021 tn?1410262957

?????????????

I have been looking into Olysio it tells me that this drug also has to be taken with Ribravarin and peginterferon, looks like its the same as Sovaldi. My question is what are the newest  2 oral drugs to treat Hep c geno type 1a. with mild cirrhosis.
18 Responses
Avatar universal
Hello! My Dr. Treats all the movie stars and he TX me with Sovaldi/Olysio w/o any others. I also was 1a. Grade 0. I just thought I would share that. I have cleared the virus. Now to stay clear! Remembering when he was talking to my insurance company and he stated in a letter that it is common in his practice to use Sovaldi and Olysio together with out any other drugs. Have a good week end and stay positive. I'm sure some one will chime in with better information and back up what they say. I just wanted to try and make you feel better. GoGG
Avatar universal
Wanted to add that with cirrhosis I think you do have to use the drugs all together for better out come. Keep us posted as to your decisions and how you are doing. I've read post from Hector about your question. Recently. . Now I wish I would have kept my mouth shut. W/O doing research and backing my words.  GoGG
Avatar universal
you might want to wait for the FDC (Sovaldi/Ledipasvir) which will be available in Nov-Dec 2014. This FDC is designed specifically for gt1a cirrohotic and non-cirrhotic. The Sovaldi-Olysio combo has been shown to be considerably less effective amongst the gt1a cirrhotic population. Personally, Im arranging for this FDC tx to include a third ingredient: GS-9451 (Vedroprivir) for myself to begin March 1, 2015. Just a little heads-up but its your decesion. Good luck reaching SVR one day.
766573 tn?1365166466
These are all pills in tablet form meaning "all oral" and no injections
Sovaldi + Olysio and Ribavirin

____________________________
There is a treatment protocol for Sovaldi, Peg and Riba.

-->  But when you posted last time and indicated you might have come up with a way to cover the Sovaldi - as well as the Peg and the Riba I felt since you were so resourceful in that arena that you might as well try and see if there is a way to treat with the Olysio and thereby ditch the Peg altogether.

If you did that then you would be taking all oral meds thus avoiding shots Pegylated interferon  ("Peg") is a heavy duty injectable you would administer once a week.

http://www.hepmag.com/articles/Olysio_Sovaldi_2501_25501.shtml

http://www.medhelp.org/posts/Hepatitis-C/Why-do-some-fail-Sovaldi-Olysio/show/2190964

_______________



766573 tn?1365166466


If you scroll down in the link I put it has studies with just the Simeprevir + Sofosbuvir and No Ribavarin.

There have been several Canadians on the forum and based on what I understand about your health system it seems you have been very resourceful in a short period of time. I think that is why I have encouraged you to seek and all oral protocol.
883021 tn?1410262957
Thank you very much, I am going to talk to my doctor for sure.
883021 tn?1410262957
its ok and Hector has been a great help.
883021 tn?1410262957
The only problem is olysio is not covered at all for canadians. Sovaldi is also not covered but seems to be approved by canadian gov.,  The government is covering the costs for Ribravarin & Peginterferon . the sovaldi cuts my treatment in half. The thing that makes me upset is my doctor could have help me from the start to get help from any programs for newer meds, I had to do it my self. So I will. And the only reason I no about programs is because of this site and people like all of you, you are my rock to make me go further. Thank you all so much
1689583 tn?1387752394
Sovaldi is approved in Quebec I and my doctor are waiting till 2
015 seeing it is only a few months away and I have time to wait to see what my options are at that time. Ifeel there is nothing I will do the Soc (sovaldi, peg.& ribavarin)  I have contacted Gilead Momentum and they have approved to pay the difference my insurance doesn't cover. I have sent all the forms they asked for as well as my doctor. I have advised them in February of 2015 we will begin tx if there is nothing else out by then. I too would rather not do interferon, so we are waiting and hoping the new drugs are available. I am gt 1a F1-F2 fibrosis
Hopefully things will get better and I hope you get tx soon.Best of luck to you.
883021 tn?1410262957
Yes I am waiting on the gilead momentum to,  I don't have insurance at all, on government assistance. The only drug thats not covered by gov. yet is sovaldi. I have exhausted all my resources to help me pay for sovaldi. If I can do this in such a short time, I will go as far as trying for the other new ones, but as you know time is not on my side for treatment, I am geno type 1a with F3/4  fibrosis. I am working on this all day and all night. I now have to work on hopefully getting something to replace the interferon, wish me luck, and good luck on your tx, when I get new info on whats happening I will post all. ty printze
1689583 tn?1387752394
Don't give up, I know how frustrated you feel right now.
1689583 tn?1387752394
I hit. the post button too fast, sorry about that. As I was saying, things will get better soon here in Canada, it is just a bit slower. I am confident by years end we will have more options. I am quite sure Gilead will cover your Sovaldi through the compassionate program and the peg and ribavarin are covered by the Medicare. You will be fine. You have to be Proctave. In the long run we will get cured I try to positive and optimistic. This forum is a wealth of information for learning, and there are very informative people who are always there. we are all in this together and must help one another. If you have any questions you can send me a message or post.Stay strong. I
Avatar universal
I am a genotype 1a, 42 year old virus, treatment naïve until now that I am on my third week of S/O, orals only.  What I can say is that the doctor should decide with the patient on what course of action to take. I refused interferon because I've seen too many people suffer with it only to relapse. I also know that it can contribute to deep depression and could not risk that.  S/O without shots is available to Genotype 1 now, and while Ledapasvir may not carry some of the sides that Olysio does, it is here now and was possible to start right away.  Everyone needs to make their own decision based on their level of virus, medical coverage possible, and so many factors.  For me, this seems to be the right drugs at the right time. I am keeping a diary of my experience with the treatment, as I feel it is important for us all to document our stories, because I firmly believe that we are the ones who are dealing with the sickness and its ramifications, and are always honest with one another.  I cannot imagine  my doctor really cares much beyond getting results and applause. I believe I am in the right hands, because I have no choice now, unless I wish not to treat. You can ready my diary at www.sovaldiary.com.  It is just my story and not meant to advise or recommend.  I just want all of us to not be in this club anymore.  I read  about side effects and my doctor says almost nobody gets them--when I know that is pure ********.  They want us to be quiet and take the treatment and keep the money train rolling, stock high, and a constant flow of new patients with dreams of a cure.  

I am grateful to all of you for your input here  I have met people who finished the "cure" and still feel like crap. So reading about after effects is of particular interest to me. Remember, we can still get other things beside HCV, during treatment and afterwards, so there are no stupid questions here. Here we all know how we feel and that only we can rely on one another for the answers.
1689583 tn?1387752394
I wish you a successful tx and SVR. Are you in Canada also?  
1751426 tn?1399007484
Quebec is the only province so far to cover the cost of Sovaldi under their provincial healthcare plan and Health Canada has approved it for use only in combination with peg & riba for genotype 1 & 4.  The next combo up for review is the sovaldi with ledipasvir.  Check out the hepbc.ca website for up to date info for Canada.  Don't know what Ontario is doing but you can also get help if you contracted the virus through a blood transfusion.  You are invited to give your input to Health Canada on this website (link on the right) also as they decide which of the new drugs to approve for use in Canada.  It is a waiting game for sure but this seems like the lates, greatest even for those with cirrhosis.
1751426 tn?1399007484
Here is the link to the sovaldi portion of the hepbc.ca website.

http://hepcbc.ca/2013/12/sovaldi-sofosbuvir-approved-by-health-canada/

Best of luck with your journey to SVR!
883021 tn?1410262957
Thank you all the information is awesome, I see my doctor on the 24th and take it from there, I will not stop, I am still worried about the peginterferon because of my depression so i am going to talk to him about another. I don't know how I got Hep C, and the docs can't explain it, all they can say I must of got it from my partner. I did have surgery back in 95 but the records have all been destroyed, and the doctor past away. So did not make a claim.
1689583 tn?1387752394
It is irrelevant how you got, no one here is to judge we are all faced with the same thing in mind which is to treat, be cured, and to live out the rest of our lives in good health to a ripe old age. We are here for each other. Keep us posted of any new development. Take care
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