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Avatar universal

From the Netherlands, a few questions about vx-950

Hi Everyone,

My name is Eduard, and I am from the Netherlands. I have a few questions about vx-950.
In march-april 2005 I was in a 14 day trail with a mono study Telaprevir (32 persons in Germany and the Netherlands)
At that moment Telaprevir was a powder, and they mix it with water,two times a day 1250mg.

My medical situation went completley different than all the others. . After six months still 99% of the virus was gone. Between month 6 and 9 my virus went up, but still 93% was gone.  
In January 2006 I started with pegasys during 52 weeks, the last 18 weeks it was a combi with Riba. The cure went well, it was never critical. And after 30 weeks I got help from Effexor.  In a few days  I will get my 6 months after treatment test.

Since a few weeks I see on the English websites news about VX-950 that is less hopeful. Can someone write  in short what are the problems with vx-950 ?

But for me the most important question is, are there more persons in vx-950 trails in America with a different reaction ?

From the Netherlands, greetings Eduard
4 Responses
148588 tn?1465782409
After enough people have completed Phase 3 trials to establish a large statistical base, someone will have to make a decision on whether any increase in long term SVR numbers is worth the trade off in rash problems other possible side effects compared to SOC.
Avatar universal
What are the rash problems, is this a big problem ? Sorry things went to fast for me at this moment
I can,t remember me that there were any rash problems in the 14 days phase 2 trials in Germany and the Netherlands.
What means SOC ?
148588 tn?1465782409
SOC = Standard Of Care  in other words, the regular treatment most doctors prescribe - pegylated IFN with ribavirin.
I haven't been following the VX trials that closely, but apparently there have been reports of a rash bad enough to discontinue treatment or use steroids to control it. There are a couple members of this board who have experience with this and can give you more from personal experience and statistics.
Avatar universal
hi eduard. the study in england/ europe (prove 2) had a group that got peginterferon and telaprevir without riba. those folks don't seem to be doing very well.  seems the study consensus for type 1 so far is soc for 24 weeks, with telaprevir for the first 12 weeks. i'm in the prove 1 study. was und after 21 days. did 12 weeks telaprevir and 48 weeks soc. going for 2 month post tx bloods this week.  sx were bad but manageable. had the rash, nausea and gastrintestinal problems. i think 9% stopped tx early due to the rash.  looks like the svr rate will be between 80 and 90%. more results should be released in november.
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