ION-1 / ION-2 / ION-3 / LONESTAR / ELECTRON statuses

[still_above_dirt]

Hello all:

I thought that it might be helpful to all of us ION-1 / ION-2 / ION-3 / LONESTAR / ELECTRON folks to post an abbreviated synopsis of their HCV and post-treatment clinical trial statuses when they find out something definitive about their viral load, with as much info as they might be willing to share. This is or the benefit of us ION-"X" people so we can see how we are all doing, as well as for the benefit of others waiting and hoping to see whether sofosbuvir plus ledipasvir with or without ribavirin for 8, 12, or 24 weeks will comprise a viable treatment strategy.

I was going to try to start building a list of what I could harvest from this site, but decided that some people may prefer that I not do that, so, if people want to share their ION1/ION2/ION3 (and even ELECTRON and LONESTAR phase 2 studies) HCV status, they can.

I was thinking that, as much as people may be willing to share, that forum name, gender, genotype, liver Bx status prior to start of treatment, in which trial you participated, treatment regimen, whether treatment-experienced or not, whether PI-experienced or not, and since post-treatment viral load is quasi-blinded, whether you got the 24-wk followup invite or the sux2BU notification, or post-treatment private viral load test outcome, or declared cured or relapsed, would be helpful to share with the Community here and provide useful information to them. My status follows this post.

Thanx, all!

[nobodyone]

I, too, have apt for 24 week test that was made when I had 11.3 lab done.  Coordinator said she gets letter stating I can come back for 24 week lab In about 2 weeks -----that letter hopefully goes out to her!  I said please let me know to confirm it for my peace of mind and Joy in knowing that.  She said she would.

Merry Christmas all!

[Geshmit]

I doubt they have the SVR24 data yet, but hopefully they will post. And what interests me is whether there are relapses from 12 week EOT to 24 EOT. That we don't know yet but they say that SVR12 is their primary endpoint.

have a great Xmas and may 2014 be the year of mass SVR

[still_above_dirt]

Thanx for posting that link (your Dec 20 post) summarizing the ION "X" trials' SVR12 data on this thread. Wonder if they'll post SVR24 data?

[Geshmit]

This is an extract from one of the financial publications: (sofosbuvir is now called Sovaldi) - there have been loads of reports over these past few weeks.

"Perhaps no study caused investors’ jaws to hit the floor harder this week than Gilead Sciences, Inc. (NASDAQ:GILD) three late-stage trials involving its recently FDA-approved hepatitis-C drug Sovaldi in combination with ledipasvir. The three trials demonstrated a sustained virologic response (an elimination of all detectable levels of disease) of between 93.1% and 99.1% in the most common type of hepatitis-C, but also the toughest to treat, genotype 1. Even more astounding, the treatment-naïve arm without the use of a ribavirin delivered a 94% SVR in just eight weeks!  What all this means is that Sovaldi could wind up giving AbbVie Inc (NYSE:ABBV)‘s direct-acting antiviral combo a run for its money in treating genotype 1 patients, especially from a factor of convenience (one pill versus up to six for AbbVie’s combo). I still believe there’s plenty of room in the hepatitis-C marketplace for two blockbuster drugs and am thrilled to see such rapid progress being made."

[pooh55811]

Wishing all of you SVR.

[Geshmit]

sorry - one more thing. Gilead already has another compound - can't remember the name of it which they are using in some trials....I think one person on this thread (or maybe the other one?) was starting it...