Aa
20gm meal or snacks/ incivek dosing
Does any one else have any menu items containing 20 gm fat? Chooosing to eat fat is new to me.
As far as my opinion on incivek dosing: I believe getting as close to every 8 hours is important because of the duration of action of the drug. If there are periods when the blood drug levels are below effective treatment drug resistance can result as well as subptimal viral killing. So, thus we are harming our chances as well as those in the future. Not a good scenerio. And of course taking with fat is essential for complete absorption thru the gut. The controlling factor is what's absorbed in getting results which over rides how much you put into the gut.
Ribaviron has a longer (half-life) duration of action as therefore can be taken every 12 hours. As the half-life of a drug reduces the importance of keeping on schedule increases.
We all want the best results from our therapy. I hate the idea of going thru this regimen and getting suboptimal results so... for me I am going to be as strict as any human being can be following protocol. Varying 1/2-1 hour is not a deal buster but still opens the door to possible sub-optimal therapy.
I agree each MD has different personal protocol they like. As a drug is on the market longer, new ways of administration become evident--but this is all new so who is to say what is best? My MD was part of the Univ of Cincinnati that participated in the incivek trials. My MD stands by a 5X dosing day with 6am incevik with meal and 8am ribaviron. this was what this study followed, and with great results--so of course my MD believes in following what has been proven. that is not to say that we will find other protocol just as effective.
As a fellow Hep C therapy patient and pharmacist my basic advice is: Make sure you eat the 20GM of fat with incivek and get as close to every 8 hours as humanly reasonable, don't miss doses. Get as close to every 12 hours for the ribaviron as possible. I will choose to separate incivek and ribaviron.
Another pharmacy 'pearl of information' is that some drugs can be given (for instance a 3 dosing/day drug) three times broken up while awake such as 8-2-8 but some require strict every 8 hour dosing. Some examples of the ones requiring strict every 8 hours are antibiotics, antivirals (incivek) and antifungals. This is due to the importance of keeping a minimum level of the med in the blood(kill level and kill time) at all times. Blood levels below 'kill levels' allows for the virus to replicate as well as 'morph' and produce resistance strains. It is possible these strains could be produced during a 3month therapy. So be as ridgid as possible-respect your MD advice (unless evidence to the contrary) and allow yourself to be human and not sweat 'the small stuff'. Allow yourself to be human if you gett off timing or meals. STRESS IN NOT A FRIEND to those on or off therapy.
Hope this helps.
Any 20GM
As far as my opinion on incivek dosing: I believe getting as close to every 8 hours is important because of the duration of action of the drug. If there are periods when the blood drug levels are below effective treatment drug resistance can result as well as subptimal viral killing. So, thus we are harming our chances as well as those in the future. Not a good scenerio. And of course taking with fat is essential for complete absorption thru the gut. The controlling factor is what's absorbed in getting results which over rides how much you put into the gut.
Ribaviron has a longer (half-life) duration of action as therefore can be taken every 12 hours. As the half-life of a drug reduces the importance of keeping on schedule increases.
We all want the best results from our therapy. I hate the idea of going thru this regimen and getting suboptimal results so... for me I am going to be as strict as any human being can be following protocol. Varying 1/2-1 hour is not a deal buster but still opens the door to possible sub-optimal therapy.
I agree each MD has different personal protocol they like. As a drug is on the market longer, new ways of administration become evident--but this is all new so who is to say what is best? My MD was part of the Univ of Cincinnati that participated in the incivek trials. My MD stands by a 5X dosing day with 6am incevik with meal and 8am ribaviron. this was what this study followed, and with great results--so of course my MD believes in following what has been proven. that is not to say that we will find other protocol just as effective.
As a fellow Hep C therapy patient and pharmacist my basic advice is: Make sure you eat the 20GM of fat with incivek and get as close to every 8 hours as humanly reasonable, don't miss doses. Get as close to every 12 hours for the ribaviron as possible. I will choose to separate incivek and ribaviron.
Another pharmacy 'pearl of information' is that some drugs can be given (for instance a 3 dosing/day drug) three times broken up while awake such as 8-2-8 but some require strict every 8 hour dosing. Some examples of the ones requiring strict every 8 hours are antibiotics, antivirals (incivek) and antifungals. This is due to the importance of keeping a minimum level of the med in the blood(kill level and kill time) at all times. Blood levels below 'kill levels' allows for the virus to replicate as well as 'morph' and produce resistance strains. It is possible these strains could be produced during a 3month therapy. So be as ridgid as possible-respect your MD advice (unless evidence to the contrary) and allow yourself to be human and not sweat 'the small stuff'. Allow yourself to be human if you gett off timing or meals. STRESS IN NOT A FRIEND to those on or off therapy.
Hope this helps.
Any 20GM
Oh, and almond croissants, or regular croissants with butter and strawberry jam are both ove 20. A full cup of granola with whole milk makes it (easier for me in the am as I seem to have "dry mouth". Sausage and egg biscuits, full fat "Mediterranean" yogurt and some almonds get there.
If you have a "Whole Foods" store close by, it has some great healthy alternatives.
I also suggest not buying 20 of something you like right away as (in my experience) your tastes change every couple of days and I was throwing stuff out.
On to my nightly Incivek dose. Peace all! (and sorry Steeler fans, but way to go Tebow!). :)
If you have a "Whole Foods" store close by, it has some great healthy alternatives.
I also suggest not buying 20 of something you like right away as (in my experience) your tastes change every couple of days and I was throwing stuff out.
On to my nightly Incivek dose. Peace all! (and sorry Steeler fans, but way to go Tebow!). :)
My Dr specifically told me to take the RIBA and Incivek together first morning dose. I would not freak out on that one. Obviously check with your Dr (I'm going to ask the question, but am not concerned)
Cheers.
Cheers.
My Dr. told me not to take any supplements with this treatment...(if flaxseed oil is considered a supplement)
please ask your Dr. first!
All the best to all of us :)
I'm glad to have found this forum.
please ask your Dr. first!
All the best to all of us :)
I'm glad to have found this forum.
stick with 6 am riba dose I take dose 2 when i eat a lite dinner around 6 helps with the insomnia Alatyr mentioned
Well I glad I read this! because I have been doing the same thing taking I Incivek at 6:00am -2:00pm and at 10:00pm and my Ribavirin at 6:00am and 10:00pm never thought about it, I will adjust it, but I do not think it matters that much with the Riba. They say it stays in your system for 6 months after your last dose. I think I have a little FOG going on here I did 2 Interferon / Riba treatments end to end 6 months before going on Incivek and was UND at week 4 so it cannot matter that much.
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