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4 week PCR question
Hi all, I started tx with Sovaldi and Olysio Sept. 16th. GT 1b, tx naïve, cc, stage 0-1 fibrosis and VL 3.8 million.
On Oct. 14th, I had4 week VL and it came back <43. It didn't say DET or UND. Im going to call Hep Dr tomorrow to see what they say, but wanted to see what you guys thought as well. For some reason I had it in my head that UND would read <5.
The test was called Ser PI QN PCR. Im not scheduled to have another PCR drawn until EOT, just a CBC and Metabolic panel at the end of week 8. So far the only sides I have is really bad dry mouth. I'm using Biotene which I used during chemo last year. It seems to help but any other ideas would be greatly appreciated.
Hope you all had a wonderful weekend and thank you in advance!
On Oct. 14th, I had4 week VL and it came back <43. It didn't say DET or UND. Im going to call Hep Dr tomorrow to see what they say, but wanted to see what you guys thought as well. For some reason I had it in my head that UND would read <5.
The test was called Ser PI QN PCR. Im not scheduled to have another PCR drawn until EOT, just a CBC and Metabolic panel at the end of week 8. So far the only sides I have is really bad dry mouth. I'm using Biotene which I used during chemo last year. It seems to help but any other ideas would be greatly appreciated.
Hope you all had a wonderful weekend and thank you in advance!
Best Answer
No surprise here that you are UD at 4 weeks on S/O. Congrats. 43 IU/ml is UD. S/O is ez street. When the doc sent me my 4 week labs (43 UD) he wrote congrats so far. You are UD.
You put a smile on my face! I will check with them tomorrow and see what they say.
You have a great day too
You have a great day too
Check with your doc or the lab to be sure but generally <43 IU/ml without a designation means undetectable or at least it used to when I was testing during treatment.
Have a great day
Have a great day
Yes, I have a copy of the report. The only result it showed was <43.
I was happy it went down but unsure if it meant UND. Thank you for responding!
I was happy it went down but unsure if it meant UND. Thank you for responding!
R: hrsepwrguy gave you an excellent, clear, explanation of its means.
As for not saying Detected lr Undetected, Did you fet a copy of theLabReport and SEE that it did not state that, for yourself, or are you just going by what they told you the Report said?
If you do not have a copy, please ask them for one. Then if it does not specify DET or UND, we can try again.
Pat
As for not saying Detected lr Undetected, Did you fet a copy of theLabReport and SEE that it did not state that, for yourself, or are you just going by what they told you the Report said?
If you do not have a copy, please ask them for one. Then if it does not specify DET or UND, we can try again.
Pat
<43 IU/ml UND is actually undetectable down to 7.1 IU/ml
Question 2. What do these test results mean: “<43 Detected” or “<43 Not Detected”?
According to the reagent manufacturer, the lower limit of detection differs from the limit of quantification. The lowest viral load this assay can accurately quantify is 43 IU/mL, but the limit of detection is 7.1 IU/mL for genotype 1 viruses, and 10 IU/mL for viruses with all other genotypes. Therefore, we can qualitatively report detection even if the viral load is under 43 IU/mL (ie, <43 Detected). Thus, “7.1 or >10 IU/mL, but <43 IU/mL). A “<43 Not Detected” means the assay did not detect HCV RNA (ie, RNA <7.1 or <10 IU/mL). This is compliant with the package insert guidelines for the new direct-acting antivirals boceprevir and telaprevir.
http://education.questdiagnostics.com/faq/HCV-RNA-PCR
Question 2. What do these test results mean: “<43 Detected” or “<43 Not Detected”?
According to the reagent manufacturer, the lower limit of detection differs from the limit of quantification. The lowest viral load this assay can accurately quantify is 43 IU/mL, but the limit of detection is 7.1 IU/mL for genotype 1 viruses, and 10 IU/mL for viruses with all other genotypes. Therefore, we can qualitatively report detection even if the viral load is under 43 IU/mL (ie, <43 Detected). Thus, “7.1 or >10 IU/mL, but <43 IU/mL). A “<43 Not Detected” means the assay did not detect HCV RNA (ie, RNA <7.1 or <10 IU/mL). This is compliant with the package insert guidelines for the new direct-acting antivirals boceprevir and telaprevir.
http://education.questdiagnostics.com/faq/HCV-RNA-PCR
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