Great news! A two log drop at 4 weeks is how they tell if you are responding--and you ARE.
Sorry to hear about your eyes. Do sun glasses help at all. The reason I asked is because I have mine right here and just put them on and the monitor is not so bright. Maybe you could put some of that window tinting film on your monitor.
I am on shot 8/24.
Hang in there!
I need to try something to make it easier on my eyes. I have just been lazy and haven't dealt with it yet. I will find something that works soon too. Thanks for the support.
A 1.9 MIL TO 160,000 IS A 6.278 LOG TO A 5.2 LOG OR A 1.07 DROP. CHECK YOUR FIGUERS AND I WILL RUN IT AGAIN.
Bobby is correct. You have a little over a one log drop. A two log drop would be 19,000 IU/ml. Still, dropping a little over one log is excellent and shows that you are responding. At this rate I'd think you have a very good chance of being non-detectible by week 12. You might ask your doctor for another VL test at week 8 to get a more exact idea of your progress.
had to use this post, i do not know which it was but it zapped me and hurt some. it was about 5 years ago and was $500 and tx and about 6 tx. worked great until peg tx. i liked your post re 50/50. agree 100%. even at stage 3 if i do not svr he will wait for new drugs. i will also. i still have short term memory laps?
Steve it looks like you are well on your way to SVR Good luck.
ok what denotes a 2 log drop and how do you figure it out? I started at 2,500,000. won't even be due for a VL test for a couple weeks as I just started but it would be nice to figure it out when I get them.
You just cross off a zero for each log.
You're starting with 2,500,000 so a one log drop would be
250,000; a two log drop would be 25,000; a three log drop would
be 2,500, etc.
What you will be looking for by week 12 is a 2-log drop (25,000 IU/ml) or better. Preferably non-detectible via a very sensitive test.
Thank you Jim. At this point I am only 1 week down 47 to go. But it is nice to know what I am looking for when blood work comes back.
As long as you have a 2 log drop you have it made!
You don't need to be UND until week 24 - that is the cut off for when they make you quit. A 2 log drop at week 4 is excellent!
You are doing it keep it up!
My doc won't be testing me until week 12 to see if I have dropped.
I go today for cbc and lites, but nothing to do with the hep c until 12, I am so short of breath as of late, even if I talk to much, which for me is a regular occurance, I have to stop and take a deep breath.
Different tests have different sensitivities. For example, some doctors use a test that goes down to only 600 IU/ml. As long as someone tests under that amount they get a negative result, but that doesn't mean they are cleared.
Take the same person, the same day, and give them a more sensitive test that goes down to 50 IU/ml, and it's possible it may turn out that they have 200 IU/ml of virus in their system. So, indeed they weren't "clear" after all, only clear with the less sensitive test.
In general, any test that reports to 50 IU/ml or below is considered sensitive. In fact, at least as of a year ago, most of the European trials never tested below 50 IU/ml.
That said, many of us here use even more sensitive tests like Quest Diagnostic's quantitative Heptimax which goes down to 5 IU/ml. That's an excellent test to use either prior to treating or during treatment, as it's both sensitive and gives you a numerical result. After treatment I decided to use Quest's qualitative TMA. It also goes down to 5 IU/ml but only tells you if you if the virus is detectible or not dectible. No number. But after treatment, the number really doesn't matter so much -- you really want to know if you still have it or if it's gone.
Going back to your question on what a 40 IU/ml viral load means. Again it depends on the sensitivity of the test. If the test is sensitive to 5 IU/ml, then the person has detectible virus in their blood, i.e. they are not clear. However, if 40 IU/ml is the tests limit, then they are indeed non-detectible according to a fairly sensitive test.
Hope this clarifies and please ask more questions because it can be a confusing subject.
Hi maamir -- sounds like you were talking about me. I had 40IU/mL at 12 weeks and the sensitivity of the test went as low as 2 IU/mL (this was the LabCorp QuantaSure). I was definitely not clear of the virus.
Bill54 explained it really good one time -- for example, I had 40 IU's of virons in 1 milliliter of blood. Now the average body has 5.6 liters of blood. 1 millilter = .001 liters. so, I may have had 224,000 IU running around in me (40 /.001 x 5.6). (if you convert that back to copies which I think are the actual numbers of virons, it was about 560,000 of the little suckers (the LabCorp conversion from copies to IU is about 40% - other labs have different conversions)
LabCorp has two QuantaSure tests and the ranges are different --
The QuantaSure tests from 2 - 2,000,000
The QuantaSurePlus tests from 10 - 100,000,000
For me, like Jim was explaining, the low end of the test is what is important. I no longer (in fact ever) needed to know if I had 100 million IU/mL in me. Thus I requested for my end of treatment PCR the QuantaSure
I didn't think too much of it - not being clear at 12 weeks since my vl was so low until a relapser posted that she had 45 IU/mL at 12 weeks and was clear thereafter and still relapsed. That gave me pause, and I decided to researh further. It was my decision to go 36 weeks after reaching clear. Whether or not I need that extra 8 weeks to reach SVR I will probably never know.
Sorry so long winded here. Sometimes I have to justify my extending treatment to myself. You may have to research the websight for whatever lab your doctor uses, but you may request a more sensitive test and they should honor it.