Aa
4 weeks post treatment
Does any one have statistics regarding the probability of attaining a svr (genome 1) if one is undected at 4 weeks post treatment
Your chances of SVR are based on when your HCV RNA become undetectable during treatment. Knowing when you became UND will give you a better idea of your chances of SVR then when others relapse.
"Most patients with genotype 1 who achieve undetectable HCV RNA do so after Week 4 of treatment. Previous studies have demonstrated that approximately 35% of genotype 1 patients achieve undetectable HCV RNA between Week 4 and 12 of treatment. Another 15% of genotype 1 patients achieve undetectable HCV RNA between Week 12 and 24 of treatment.” Virtually no patients will achieve undetectable HCV RNA levels after Week 24 if they have not done so already by that time point, regardless of genotype".
If UND by week 4 = 90% chance of SVR.
If UND by week 12 = 66% chance of SVR.
If UND by week 24 = 45% chance of SVR.
Ferenci P, Fried MW, Shiffman ML, et al. Predicting sustained virological responses in chronic hepatitis C patients treated with peginterferon alfa 2a (40 KD)/ribavirin. J Hepatol. 2005;43:425-433.
Cheers.
Hector
"Most patients with genotype 1 who achieve undetectable HCV RNA do so after Week 4 of treatment. Previous studies have demonstrated that approximately 35% of genotype 1 patients achieve undetectable HCV RNA between Week 4 and 12 of treatment. Another 15% of genotype 1 patients achieve undetectable HCV RNA between Week 12 and 24 of treatment.” Virtually no patients will achieve undetectable HCV RNA levels after Week 24 if they have not done so already by that time point, regardless of genotype".
If UND by week 4 = 90% chance of SVR.
If UND by week 12 = 66% chance of SVR.
If UND by week 24 = 45% chance of SVR.
Ferenci P, Fried MW, Shiffman ML, et al. Predicting sustained virological responses in chronic hepatitis C patients treated with peginterferon alfa 2a (40 KD)/ribavirin. J Hepatol. 2005;43:425-433.
Cheers.
Hector
"My understanding is the highest percentage of relapse occurs in the first 4 weeks. Some people on this sight have said that 85-90 percent occur in this timeframe. So this is really good news for you. maryellen"
I just looked at several studies today and they said the same. If you need them I can get the cites for you.
I just looked at several studies today and they said the same. If you need them I can get the cites for you.
When did you become undetected during tx and what sensitivity test did you have post-tx?
My understanding is the highest percentage of relapse occurs in the first 4 weeks. Some people on this sight have said that 85-90 percent occur in this timeframe. So this is really good news for you. maryellen
Have an Answer?
You are reading content posted in the Hepatitis C Community
Learn about this treatable virus.
Getting tested for this viral infection.
3 key steps to getting on treatment.
4 steps to getting on therapy.
What you need to know about Hep C drugs.
How the drugs might affect you.
These tips may up your chances of a cure.
A list of national and international resources and hotlines to help connect you to needed health and medical services.
Herpes sores blister, then burst, scab and heal.
Herpes spreads by oral, vaginal and anal sex.
STIs are the most common cause of genital sores.
Condoms are the most effective way to prevent HIV and STDs.
PrEP is used by people with high risk to prevent HIV infection.
