We are seeing this DR. for autoimmune hepat. Taking blood work every 4 months. Has been in remission for 3 years now. Lastest lab test was: CBC-NORMAL, Complete liver panel-(ALT 14,AST 14)NORMAL, PT-12.2 NORMAL, ANA- measures 1-320 which is more elevated than test before, SMA- 1-20 which is borderline or negative and less than last blood test. Is on imuran 50mg only. The DR. Has asked to increase Imuran to 75mg based on the elevated ANA test. He asked to increase the Imuran 4 months ago, but decided not to and wanted to only remain on the 50mg since all tests, except the ANA came back normal. The DR. Has also asked to do another liver Biopsy which already had done about 3 or 4 years ago. Which has absolutely refused to do again. The Dr. then suggested that an Ultrasound be done on liver, which once again refuses to do. The Dr. Has suggested on his next blood work to take this new blood test called Fibrospect,WHich will take (which will be able to measure how much inflammation, fibrosis, and damage is done to the liver. And I think some part still believes this may have just been an acute hepatitis because of where we used to live (We owned a well, which we found out was contaminated water with cholifer (Feces) in the water). Has been in remission with normal liver labs for 3 years now and only on 50mg imuran. Taking blood labs every 4 to 6 mths. Can the fibrosis have reversed itself from original biopsy and improved? What causes ANA to elevate? Could I have given him anything to cause this to elevate (germs,cold,etc)? Or does the ANA flunctuate on own for no reason.