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Avatar universal

Finished new meds 1 month ago and virus is back...

Has anyone else finished solvildi and ribaviren and virus has come back.... I did the med 4 24 weeks and was told my hvl was 0 . I received a call from my dr and was now told my hcv is in the 500 I'm a little confused 2 week ago I was 0 now I'm in the 500.... Thank you Anthony
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Avatar universal
Sorry to hear but it seems like you have relapsed. None of these meds are 100% cure rate. Maybe seek a retest or ask your doctor about it. Give yourself some time and get ready to take a shot at these "newer" drugs do out soon. I know that kick in the gut feeling you have but don't give up. You will be cured, just hang in there... Best to you
Helpful - 0
Avatar universal
Sorry to hear that you have relapsed.  My husband completed the same 24 week treatment on July 30th.  He will have his four week HCV post treatment test next week.  We know there is a possibility that he may relapse although he was undetected since week 6 of the treatment. There is no guarantee with these treatments that you will reach SVR (i.e.  UND at 12 weeks post treatment).  
     Should my husband relapse, our backup plan is the new treatment (Sovaldi/Ledipasvir combo pill)  to be FDA approved in October and probably available in November.
     Your doctor can guide you on what's next for you.  Please don't despair.
There are several new treatments in the pipeline and one of them will surely be a good fit for you. I know how disappointed you must be. Hang in there.

Nan

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10175413 tn?1427170251
Hi there....new to this blog...I will be in my 4th week tomorrow, taking Sov/RIBA . I'm a little scared now. Today I had my SOT labs and am hoping for UND.  What we we tours at wk 3 if I can ask
Helpful - 0
10175413 tn?1427170251
Sorry....that was suppose to be what was your VL @ wk 3
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215858 tn?1420171556
Romello, I'm sorry that the drugs failed you.  

I believe you are the first G3 reporting a relapse on this forum but because your protocol is 24 weeks there probably aren't a lot of people who have completed treating yet.  Unfortunately, there will be others.  Take heart tho, your time will come, as there are new drugs coming in October.

Nan, glad to hear your husband is done!!!  Stay positive.  I'm rooting for him to clear!  

V.
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Avatar universal
That is a blow for sure. Not to worry though, next time around.
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Avatar universal
Sorry to hear of your relapse.  I'm sure it's hard to take after 24 weeks of Tx.
As everyone has said, the new miracle pill will be out in a few months and that should be your majic ticket.
Keep the faith, as your day is coming.

...Kim
Helpful - 0
446474 tn?1446347682
Anthony, I am sorry to hear that the virus has returned after your treatment.

Unfortunately current treatments are not a 100% cure. Thankfully better treatments will be available for those who are not cured with the treatments that are available now.

Please realize that having an undetectable viral load has nothing to do with treatment success. Everyone becomes undetectable on Sovaldi based treatment and stays undetectable for as long as they continue to take the drugs. It is only when the treatment is stopped that we find out if we are cured or not. That is why our viral load is tested for up to 12 weeks (sometimes also 24 weeks) after stopping the treatment. To learn if we are cured. Like yourself, most people's virus comes back (relapse) within the first 4 weeks after stopping treatment. Everyone who fails this treatment does so by relapsing.

A phase 3 trial is ongoing evaluating a 12-week course of daclatasvir 60 mg once daily plus sofosbuvir/Sovaldi 400 mg once daily in treatment-naive and treatment-experienced patients with genotype 3 infection. Hopefully we will hear good results.
A phase 2 trial is now examining a 12-week course of the ritonavir-boosted investigational NS3/4A protease inhibitor ABT-450/r plus the investigational NS5A inhibitor ABT-530, with or without ribavirin in treatment-naive patients with genotype 3 infection.

Hang in there.
Hector
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Avatar universal
What Hector said.  I, too, am Gt3 and  talked w/ my Dr last visit about what next, if this same protocol doesn't work.

He said that we will probably go w/ the sol/daclatasvir combo as that seems to be the best, as far as he cam
n tell, for Gt3.

You are not alone.  Take a deep breath, cut yoursrlf some slack and prepare to attack the dragon again.  Just look, you already gave your liver 24 wks of rest.

Hang in there.  Best wishes for SVR for all of us soon!  Pat
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Avatar universal
Anthony,

As noted in my message to you and as folks have stated above, there are supposed to be new drugs/combos soon that will have greater efficacy for genotype 3 (and apparently, better side effect profiles than the treatment you just finished/endured). I know your faith is strong...and that you have those wonderful grandchildren to bring a smile to your face in the meantime! I wish you improved health and strength.....jo
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10175413 tn?1427170251
Can u tell me what ur VL was at 3 weeks...wtg patiently for an answer. Went yesterday for SOT labs.  So very sorry to hear your news.....I had asked this question yesterday but no response...pls help...thx
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Avatar universal
Virtual hugs to you. So sad to hear this....Only compensation is that I'm glad we're in an age when they are more and better developments coming around the corner...
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Avatar universal
Read Hectors post above.  It is true.  Can't say it better.  I am on sovaldi/riba...While on treatment I was UND...then I went DEC (detected)...now I am back to UND.  But as I have been saying in almost all of my posts about treatment UND does not mean SVR.  

Hectors post above: Please realize that having an undetectable viral load has nothing to do with treatment success. Everyone becomes undetectable on Sovaldi based treatment and stays undetectable for as long as they continue to take the drugs. It is only when the treatment is stopped that we find out if we are cured or not. That is why our viral load is tested for up to 12 weeks (sometimes also 24 weeks) after stopping the treatment. To learn if we are cured. Like yourself, most people's virus comes back (relapse) within the first 4 weeks after stopping treatment. Everyone who fails this treatment does so by relapsing
Helpful - 0
10175413 tn?1427170251
Thx so much for a response. I'm not sure what's going on with the brain these days.....I am familiar with most of this info, however my dr says he would be shocked if I did not clear the virus 4 wks EOT.  I've been so positive so far but as I read various blogs I realize there are quite a few relapses with this protocol.  Are you close to the end of your tx?  I wish you much success with your tx to rid your body of this beast. I would like to keep in touch with you and your progress and if I can share mine as well if I have questions. If you don't mind...thank u again & take care
Debbie
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Avatar universal
Just wanted to say that I'm so proud of you.  We will overcome this with the grace of God.  Keep the faith.  Love GG
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