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Avatar universal

Genotype 2 SRV?

I'm type 2 and almost at the end of 12 weeks of Sovaldi and Ribavirin. I have been looking around for results for genotype 2's since info is thin on the ground compared to type 1. I have heard that the sovaldi/ribavirin combo can be repeated for type2's in cases of relapse. Has anyone else heard this? It would be nice to have some back up hope for type 2's as Harvoni is not for us.

livelife777, cured
hopein Pa, cured
nursehepc, cured
verdugo, cured
wyosue, cured
okieson, cured
jimmymose, cured
klonny55,cured
orphanedhawk, cured

dkus... maybe cured?

drangonars, relapsed
buckoffbrewer, relapsed
16 Responses
Avatar universal
Waiting to start 24 weeks of sovald rib. Ins is putting me through a few hoops. I your a g2 and relaspe we have no other option.  I relaspers on the old tx peg/rib also. Just my opinion is if you relasper on std tx 24 weeks should be standard on sov/rib. Peace
317787 tn?1473358451
Hi I found something from last year.  I hope it helps.  I am sure others will be a long soon to help out.  
Harvoni was just approved in October.  People just started to take.  I will try to find more up to date information..

http://www.medhelp.org/posts/Hepatitis-C/hep-c-geno-2-stage-4-cirrhosis/show/2008035
Avatar universal
Thanks for the reply, and good luck with this next round of treatment.
Avatar universal
Thanks Dee, I copied this info from where you directed me. Although they may be outdated I will be phoning Gilead about these stats. I'm curious about... Non-cirrhotics G2 with 16 weeks of treatment had a SVR rate of 100%. If that is so why isn't 16 weeks the standard protocol?
[There is no point in asking my doc he always seems to be playing catch up too.]


Results:
Non-cirrhotics G2 with 12 weeks of treatment had a SVR rate of 96%
Non-cirrhotics G2 with 16 weeks of treatment had a SVR rate of 100%

Cirrhotics G2 with 12 weeks of treatment had a SVR rate of 60%.
Cirrhotics G2 with 16 weeks of treatment had a SVR rate of 78%
317787 tn?1473358451
Hi I found this on HepMag, this was dated December 4th 2014, I hope it helps.  Take care, Dee


AASLD HCV Treatment Recommendations
for treatment-naive patients who are eligible to receive interferon
Recommended Alternative
Genotype 1 Sovaldi + ribavirin + PEG* for 12 weeks Olysio for 12 weeks + ribavirin + PEG* for 24 weeks**
Genotype 2 Sovaldi + ribavirin for 12 weeks none
Genotype 3 Sovaldi + ribavirin for 24 weeks Sovaldi + ribavirin + PEG* for 12 weeks
Genotype 4 Sovaldi + ribavirin + PEG* for 12 weeks Olysio for 12 weeks + ribavirin + PEG* for 24–28 weeks
Genotype 5 or 6 Sovaldi + ribavirin + PEG* for 12 weeks ribavirin + PEG* for 48 weeks


AASLD HCV Treatment Recommendations
for treatment-naive patients who are NOT eligible to receive interferon
Recommended Alternative
Genotype 1 Sovaldi + Olysio +/- ribavirin for 12 weeks Sovaldi + ribavirin for 24 weeks***
Genotype 2 Sovaldi + ribavirin for 12 weeks none
Genotype 3 Sovaldi + ribavirin for 24 weeks none
Genotype 4 Sovaldi + ribavirin for 24 weeks none
Genotype 5 or 6 none none
317787 tn?1473358451
Well, now I wish I could delete, it was a chart which showed each geno type and the prefered way to treat with an alternate way.

So geno type 2 is the Sovaldi and Riba and there is no alternate.
I am sorry.  I hope that the tx works for you.  I will continue to search, the HepMag site may be helpful.
Dee
683231 tn?1467323017
The AASLD updated on December 19th when AbbVie was approved here is the link

http://www.hcvguidelines.org/full-report-view

Not much has changed for GT 2 unfortunately

Retreatment Box. Summary of Recommendations for Patients in Whom Previous Treatment Has Failed

Recommended regimen for patients with HCV genotype 2 infection, in whom prior PEG-IFN and RBV treatment has failed.

Daily sofosbuvir (400 mg) and weight-based RBV (1000 mg [75 kg]) for 12 weeks to 16 weeks is recommended for patients with HCV genotype 2 infection, in whom prior PEG-IFN and RBV treatment has failed.


Alternative regimen for patients in whom previous PEG-IFN and RBV treatment failed who have HCV genotype 2 infection and are eligible to receive IFN.

Retreatment with daily sofosbuvir (400 mg) and weight-based RBV (1000 mg [<75 kg] to 1200 mg [≥75 kg]) plus weekly PEG-IFN for 12 weeks is an alternative for patients in whom previous PEG-IFN and RBV treatment failed who have HCV genotype 2 infection and are eligible to receive IFN.


Per the current guidelines

683231 tn?1467323017
Here is some info about the fission clinical trial looks like 97% cure for GT2
See page 5 for results by genotype

http://depts.washington.edu/hepstudy/presentations/uploads/85/fission.pdf

I missed that Petra is treatment naive

Here is the new report for treatment naive

Recommended regimen for treatment-naive patients with HCV genotype 2 infection.

Daily sofosbuvir (400 mg) and weight-based RBV (1000 mg [75 kg]) for 12 weeks is recommended for treatment-naive patients with HCV genotype 2 infection.

Rating: Class I, Level A

Extending treatment to 16 weeks is recommended in patients with cirrhosis.

Rating: Class IIb, Level C

Alternative regimens for treatment-naive patients with HCV genotype 2 infection.

None.

If you have cirrhosis maybe you can see if your doctor will extend treatment to 16 weeks.

Good luck
Avatar universal
Thanks great info! I am seeing my doc on Monday.
Avatar universal
The answer that I got on Monday was that even genotype 2's are only being prescribed 12 weeks of Sovaldi and Ribavirin [ at least where I am ]. I did not have a biopsy or a fibroscan so I posed the idea that there was no definitive  way to tell that I did not have cirrhosis. My doctor replied that she was basing her "not cirrhotic" diagnosis on the fact that my liver enzymes have never been elevated, that I had a clear ultra sound, none of the usual symptoms and that since I am [in her words] skinny she could palpate my soft/squishy liver easily.  I hope she is right... I took my last pills yesterday.

On to the next stage of the waiting game. I guess we should try to stay in the moment as much as possible. Tricky business!
Thanks,
Petra

Avatar universal
Hi Petra.  Congrats on finishing Tx.  Sounds to me as tho you should clear without problem.  May I ask your viral load, and dosage of Ribavirin?  I do believe not only my low viral load and max Riba dose pushed me into the plus category.  I'm 110 lbs and took 1,200 mg of the Riba without reduction.
Seems like overkill as its weight based, but I got lucky as I'm also cirrhotic.

Rest easy as geno 2s are the easiest to treat.  Even tho in a prior post I did mention that 24 weeks was the preferred option, being non cirrhotic will likely be the ticket which in the end will give you your freedom.  I treated for only 12, but my viral load was a mere 357.

Since I have your attention would like to address some additional thoughts for you.  As we all know everyone is an individual and no 2 experiences are the same when it comes to Tx, but I had many post Tx issues.  I only bring this up so that if it should happen to you please know its possibly part of the norm.  The majority of my post conflicts were more mood related vs physical.
Felt emotionally outta sorts for a few months as my neurotransmitters had to reboot to feel like my old self.  OK I was an emotional wreak!!!!!  No honestly one day I would cry, and the next day I would be superwoman.  The Riba tends to stick around for a few months longer then anticipated.  Alas, in the end I never felt better.  So worth the ride and would def do it again.  

Think your in the drivers seat and my bets on you.  Just give yourself some slack and a pat on the back for getting thru Tx.
Best Wishes
.....Kim
Avatar universal
Thanks Kim,

I am glad to be at the end of treatment, with no pills to remember, even though I think now that I may have felt more secure while I was killing the virus with meds... rather than waiting to see if any of the little beggars were left to replicate another day.

I went from 3.5 mil to "18" by week 4 , so my doc did a VL at week 6 to reassure me. I was undetected at week 6 and at 8. I am hopeful that week 12 will be the same. [ I am getting my blood work done this Monday  4 days after the end of treatment.]

I was on 400 of sovaldi daily and 800 MG of ribavirin daily. Given that I weigh 118 at 5'7" you were taking quite a bit more for your size!
Again. all I can hope is that they got the dosage and the length of treatment right with me.

During treatment I have described my emotions as being heightened and my temper as being shortened. The other thing that sometimes happens is that I have a blunted affect. It is like I haven't the ability to engage with people, as if my mind turns to cement. This is definitely unusual and unwelcomed, and I hope it happens less as time goes by.

Thanks for the advice and the encouragement.

Petra
Avatar universal
Hi Kim,

the twelve weeks waiting wondering if I was relapsing was a real education... I think I have a touch of ptsd. I have had almost exactly twelve hours to get used to achieving SVR with the twelve week protocol. The nurse practitioner assigned to my case called me early today. She considers this a cure and I guess I do too. I think she was expecting a bigger reaction, so I did my best. I know I will feel better as I relax into the knowledge that I'm in the clear.

Petra



Avatar universal
GT 2 also,  I was fortunate, achieved SVR 12 wks, Solvaldi/Riba.  I was told if it failed, no options, but treatment would be in the future for us..so hang in there, and praying for your good news soon...mary
Avatar universal
Congratulations on the SVR12 - even if you don't believe it's real yet!  It will hit you all at once in a few days!  then you will experience the 'Wow' factor, I am sure.

To help you along, I will remind you that you have just stepped up that last step onto the dais to get your Dragon Slayer Supreme Insignia!

Pow, another Dragon bit the dust!

Blessings,

Pat
Avatar universal
Congratulations on beating this virus!!!!!!!!
Honestly the void that you are feeling does take time to mend.  I think this happens particularly to those of us that are sensitive to medication.
Also, keep in mind that while on Tx we are excited and anxious.  For some it's a letdown when Tx is over as our expectations are so high.  We tend to think that being cured will suddenly make our life perfect, and it doesn't work that way obviously.  The Riba is still in your system typically for 6 months post Tx so you must still contend with that.
Keep your chin up as slowly the Riba gives way and you will start feeling like yourself.  Give yourself the freedom and flexibility to slowly move forward as it does take time.  It is like PTSD as you've been fighting this enemy within for so long.  You will feel better in time, and forever be grateful for having these meds available to now become cured.
I promise you will eventually feel AOK.
Best to you
......Kim
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