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Genotype 3 questions
Hi everyone. I just found out yesterday that my genotype is 3. I was so hoping it was at least a type that would fall under Harvoni but from what I read at least, g3 won't work with Harvoni. Is this right? If so, are there any meds out now that have high cure success rates for g3's? Or perhaps something coming soon? I go for an ultrasound May 4 so I will have more information. The doc took 18 tubes of blood from me but all the nurse told me so far is my type. I asked her the viral load but she said it was hard to understand. So i guess I need to wait for the doctor to explain more. Thank you in advance for any help.
P.S. Lynn you did do an excellent job answering my question and I thank you for the information links
Ok I must have read something wrong then about riba. My only concern about waiting is that if g3 is harder to treat then maybe I shouldn't wait. But my doc will know what's best. I do keep checking the trials also to see if something pops up in my state and will discuss that with my doctor as well. So much to read out there. I'm constantly searching as much information as I can.
Meant to say, Depending on your stage of fibrosis and what your ultrasound shows, I would have a discussion with the doctor about whether you should wait, TREAT NOW, or possibly look for a clinical trial.
Lynn did a great job answering your question. I don't think yhou have to be too concerned about using ribavirin as long as there is no interferon. Ribavirin needs interferon to be really evil. If I were you. And, as Lynn pointed out, the cure rate for treatment naive patients is about 94%. There will be other drugs coming out for genotype 3 but it looks like it may be a year or two. Depending on your stage of fibrosis and what your ultrasound shows, I would have a discussion with the doctor about whether you should wait or possibly look for a clinical trial. I think, but am not positive because thee is so much to remember, that daclatasvir is being looked at with one of the newer drugs for genotype 3. Hopefully someone who knows more about this will let you know.
I think you expected to be geno 1 because over 70% of patients in the U.S. are genotype 1.
I think you expected to be geno 1 because over 70% of patients in the U.S. are genotype 1.
See also this conversation
http://www.medhelp.org/posts/Hepatitis-C/sov-rib--geno-type-3a-24-weeks/show/2552271#post_12427008
http://www.medhelp.org/posts/Hepatitis-C/sov-rib--geno-type-3a-24-weeks/show/2552271#post_12427008
Hi AWorriedMom. I do like the doc so far. His nurse tells me he is very thorough. He did all kinds of bloid work. I'm just anxious to put this behind me just like the rest of you on here. I appreciate you answering my questions. I'm not sure how I feel about the 70% part. Idk why I assumed I would be g1. Maybe I was hoping. Does the ribs have tough side effects and are there any new meds coming out for g3 this year without ribs that anyone is aware of? TIA again for any and all help.
Interferon and ribavirin have about a 70% cure rate for geno 3. But there will be much easier drugs in the very near future without interferon. Talk to your doctor after your ultrasound and see what he says. Did you like him?
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Per the current recommendation of the American Association for the Study of Liver Diseases (AASLD)
http://www.hcvguidelines.org/full-report/initial-treatment-hcv-infection
Recommended regimen for treatment-naive patients with HCV genotype 3 infection.
Daily sofosbuvir (400 mg) and weight-based RBV (1000 mg [75 kg]) for 24 weeks is recommended for treatment-naive patients with HCV genotype 3 infection.
The SVR rate (cure) using this treatment reported in the "Valance" clinical trial for treatment of GT 3 without cirrhosis the overall SVR12 rate was 84% and was higher among treatment-naive than -experienced patients (93% vs 77%, respectively).
Alternative regimens for treatment-naive patients with HCV genotype 3 infection.
Daily sofosbuvir (400 mg) and weight-based RBV (1000 mg [75 kg]) plus weekly PEG-IFN for 12 weeks is an acceptable regimen for IFN-eligible, treatment-naive patients with HCV genotype 3 infection.
The combination of sofosbuvir plus PEG-IFN and RBV was evaluated in patients with HCV genotype 3 infection. In 2 phase II clinical trials, PROTON and ELECTRON, 38 of 39 (97%) treatment-naive patients with HCV genotype 3 infection achieved SVR with sofosbuvir plus PEG-IFN (4-12 weeks of therapy) and RBV. (Gane, 2013b) For many patients with HCV genotype 3 infection, the adverse effects and increased monitoring requirements of PEG-IFN make this less acceptable than the recommended regimen of sofosbuvir plus weight-based RBV. However, the shortened treatment period may be of interest to some.
Sofosbuvir is sold as Sovaldi.
The following regimens are NOT recommended for treatment-naive patients with HCV genotype 3 infection.
◾PEG-IFN and RBV for 24 weeks to 48 weeks
Rating: Class IIb, Level A
◾Monotherapy with PEG-IFN, RBV, or a direct-acting antiviral
Rating: Class III, Level A
◾Telaprevir-, boceprevir-, or simeprevir-based regimens should not be used for patients with genotype 3 HCV infection.
Rating: Class III, Level A
Hope that help but your doctor will determine what is best for you
Good Luck