Genotype 3........

[samarjahangir]

I have read somewhere that geno 3 progresses much more faster than geno 1............ I mean geno 3 damages the liver much faster than geno 1............is it true?

[pooh55811]

One other link:

"Second, compared with other genotypes, genotype 3 is associated with a higher incidence of hepatic steatosis and the rapid progression of liver fibrosis [6]. We have previously shown that the median rate of the progression of fibrosis per year is 0.25 (0.0–1.5) fibrosis units in patients with genotype 3 in India and higher in patients who acquire infection after 30 years of age. The median time for progression to cirrhosis was 16 years [7]. According to a recent meta-analysis, the odds ratio for the association of genotype 3 infection and accelerated progression of liver fibrosis was 1.52 in single biopsy studies suggesting faster fibrosis progression compared with other genotypes [8]."

http://hepatitiscnewdrugs.blogspot.com/2012/01/treatment-of-patients-with-genotype-3.html

[pooh55811]

Statistically, HCV Genotype 3 is associated with rapid progression of liver fibrosis.

I just want to add a couple of articles and conclusions to Rivll's list.

Vaccine and Infectious Disease Division
The genotype of liver disease
Rachel Tompa

"Approximately 170 million people, or three percent of the world’s population, is chronically infected with the hepatitis C virus (HCV).  Some fraction of these people will progress to liver fibrosis, a dangerous condition where scar tissue forms in the liver, but many risk factors for progression remain unknown.  In a study of 1,189 hepatitis C patients, VIDI affiliate investigator Dr. Pierre-Yves Bochud and colleagues found that a certain subtype of the virus, HCV genotype 3, is associated with rapid progression to fibrosis.

Previous smaller studies had hinted at an association between this genotype and liver fibrosis.  The study by Bochud and colleagues was able to draw more concrete conclusions by using a larger number of patients and two different statistical methods to estimate progression to liver fibrosis.  One method assumed that progression to fibrosis was equal at different stages of liver disease, and the other used statistical estimations to predict differences in progression at different disease stages.

The scientists used data from the Swiss Hepatitis C Cohort Study, which enrolls HCV infected patients at eight different Swiss hospitals.  The presence and degree of liver fibrosis was determined by liver biopsy. Taking into account other risk factors for hepatitis disease progression, such as age, alcoholism, and other infections, the authors found that genotype 3 is associated with more rapid progression to liver fibrosis than other HCV genotypes.  These results may improve disease outcome for patients with genotype 3 by allowing clinicians to choose more appropriate treatment strategies in this population.

Genotype 3 is associated with accelerated fibrosis progression in chronic hepatitis C.

http://fhcrc.org/en/labs/vaccine-and-infectious-disease/news/publication-spotlight/the-genotype-of-liver-disease.html


And this:

CONCLUSIONS:

"This study shows a significant association of genotype 3 with accelerated fibrosis using both stage-constant and stage-specific estimates of fibrosis progression rates. This observation may have important consequences for the management of patients infected with this genotype."

http://www.ncbi.nlm.nih.gov/pubmed/19665246?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

[rivll]

Yes, there is an association between HCV gen. 3 and accelerated fibrosis.

http://www.medscape.com/viewarticle/752097

The progression of liver fibrosis in chronic hepatitis C has long been considered to be independent from viral genotypes. However, recent studies suggest an association between Hepatitis C virus (HCV) genotype 3 and accelerated liver disease progression.
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http://www.hivandhepatitis.com/hep_c/news/2009/102709_a.html

Infection with hepatitis C virus (HCV) genotype 3 may increase the risk of accelerated fibrosis progression compared with other viral genotypes, according to a Swiss study published in the October 2009 Journal of Hepatology. This rapid progression -- combined with good response to interferon and the fact that experimental oral anti-HCV agents are less effective against genotype 3 -- suggests that such patients should receive prompt interferon-based therapy.

[willbb]

Not always ,as there are no concrete certainties when it comes to HCV,however this is true of some with Geno3  

You may be intesested in looking over the article below(excert included)

Best....

Will

http://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2011.02715.x/full

Second, compared with other genotypes, genotype 3 is associated with a higher incidence of hepatic steatosis and the rapid progression of liver fibrosis [6]. We have previously shown that the median rate of the progression of fibrosis per year is 0.25 (0.0–1.5) fibrosis units in patients with genotype 3 in India and higher in patients who acquire infection after 30 years of age. The median time for progression to cirrhosis was 16 years [7]. According to a recent meta-analysis, the odds ratio for the association of genotype 3 infection and accelerated progression of liver fibrosis was 1.52 in single biopsy studies suggesting faster fibrosis progression compared with other genotypes [8].