boceprevir or telaprevir?

[rexx73]

hello there,


today i got a call from my doc that i could start now with boceprevir if i want.
but i can also go with telaprevir wich i would became in a "early acess trial"but still dont know if i really qualify for this trial,have to wait about 5 weeks.
my question is,are the svr rates with boce or tela the same or is one of them significant better?

thanks for some input

[Advocate1955]

http://www.medhelp.org/user_journals/show/332526/Incivek-or-Victrelis

[80mecheng]

I am in week 22 of what will be 28 week Vic & all treatment as a result of being undetectable at week 8.  When my doctor recommended Vic over Incivik I was surprised because the general press suggest Incivik was more effective.  His rationale was Incivik had some significant side effects (anal pain, rash...) that made completing treatment difficult for some and once this treatment fails, it can't be repeated.  Someone earlier suggested Vertex stacked the deck with easier patients.  I do know Merek had a high population of failed responders and about a 90% success rate for naive Geno type 1, which is my situation.  All I can say is so far so good but this is a grind, I don't know how people did this for 48 weeks.

[brianmo]

If you go on the website for victrilis, if that is what you decide to do and you have insurance and pay a copayment, there is a coupon you can get that will pay 200 towards your copayment each month for twelve times. My co pay each month is about 595.00 so this helps. There is also one for interferon. If you are getting any type off assistance the coupons from the companies will not help.  I have not found one for Ribavirin .

Mo

[slagle2]

I think there is a good bit of cost difference with Boceprevir being cheaper and this could help if there is a co-pay involved as there is in my case.  I'm very interested in this thread because I need to decide by my November 1 doctor's appointment.  

[Gizmo103]

Rexx73 you are right. The tx protocol for Incivek is to start it with the INF/RIB. From my understanding the treatments have similar results with Incivek slightly ahead, but Vertex (Incivek makers) did stack there clinical trials with a lot of easy to treat Hep C gene encoding (see section 12.5 entitled "Pharmacogenomic" from their prescribing info.
http://pi.vrtx.com/files/uspi_telaprevir.pdf
Maybe VIK Manu. did the same, but kinda messed up if u ask me.

[willbb]

Copyman is correct ...the SVR rates on the two drugs were fairly similar in trials.
Asa previous partial responder the protocol is to do the  triple therapy with Incivek for 48 weeks and the Victrelis therapy for either 36  or 48 weeks ..depending on your  early results.
Best to you...
Will

[rexx73]

iam a previous partial responder.what stage iam right now i dont know but biopsy before 3 years said f3.

[cbw36]

I believe you mean 24 vs 28 weeks with response guided therapy. Also depends if previous non/null responder or cirrhotic. Also, incivek is 12 weeks vs 24 or more with Vic. Confusing, I knoe

[copyman]

svr rates are very close however Telaprevir offers possible treatment of only 24 weeks vs 48 with boceprevir.
good luck