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HCV Guidelines UPDATED 8-7-2015 incl daclatasvir.and more

Guidance Sections Updated August 7, 2015
The Initial, Retreatment, Monitoring, and Unique Populations (HIV/HCV Coinfection, Decompensated Cirrhosis, Post-Liver Transplantation, and Renal Impairment) sections have been revised based on newly available therapies and data.

http://www.hcvguidelines.org  HCV Guidance: Recommendations for Testing, Managing, and Treating Hepatitis C

http://www.hcvguidelines.org/news/guidance-sections-updated-0

Links to the updated pages are at the above link
accessed Auguest 8, 2015

Major updates are for the recently FDA approved daclatasvir.(GT3) but also off label use for GT1 & GT2

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Excerpt only shown for GT2  Please go the links to read the complete info for GT2 and the other GT's

Recommended regimen for treatment-naive patients with HCV genotype 2 infection.
Daily daclatasvir (60 mg*) and sofosbuvir (400 mg) for 12 weeks is recommended for treatment-naive patients with HCV genotype 2 infection who cannot tolerate RBV.

Rating: Class IIa, Level B

Daily sofosbuvir (400 mg) and weight-based RBV for 12 weeks is recommended for treatment-naive patients with HCV genotype 2 infection.

Rating: Class I, Level A

Extending treatment to 16 weeks is recommended in patients with cirrhosis.

Rating: Class IIb, Level C

*The dose of daclatasvir may need to increase or decrease when used concomitantly with cytochrome P450 3A/4 inducers and inhibitors, respectively. Please refer to the prescribing information and the section on HIV/HCV coinfection for patients on antiretoviral therapy.

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Recommended regimen for patients with HCV genotype 2 infection in whom prior PEG-IFN and RBV treatment has failed.
Daily sofosbuvir (400 mg) and weight-based RBV for 16 weeks or 24 weeks is recommended for patients with HCV genotype 2 infection, in whom prior PEG-IFN and RBV treatment has failed.

Alternative regimen for patients with HCV genotype 2 infection who are eligible to receive IFN, and in whom prior PEG-IFN and RBV treatment has failed.
Retreatment with daily sofosbuvir (400 mg) and weight-based RBV plus weekly PEG-IFN for 12 weeks is an alternative for patients with HCV genotype 2 infection who are are eligible to receive PEG-IFN, in whom previous PEG-IFN and RBV treatment failed.

Rating: Class I, Level A

Recommended regimens for patients with HCV genotype 2 infection in whom prior sofosbuvir and RBV treatment has failed.
Daily daclatasvir (60 mg) plus sofosbuvir (400 mg) for 24 weeks with or without weight-based RBV is recommended for patients with HCV genotype 2 infection who are not eligible to receive IFN, in whom previous treatment with sofosbuvir and RBV has failed.

Rating: Class IIa, Level C

Retreatment with daily sofosbuvir (400 mg) and weight-based RBV plus weekly PEG-IFN for 12 weeks is recommended for patients who have HCV genotype 2 infection, who are eligible to receive IFN, and in whom previous treatment with sofosbuvir and RBV has failed.

Rating: Class IIa Level C
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Always remember so please revisit every time you consider any recommendations
NOTICE: Guidance for hepatitis C treatment in adults is changing constantly with the advent of new therapies and other developments. A static version of this guidance, such as printouts of this website material, booklets, slides, and other materials, may be outdated by the time you read this. We urge you to review this guidance on this website (www.hcvguidelines.org) for the latest recommendations.

1 Responses
Avatar universal
Thanks Jimmy
Geno 2s have faired well so far with tx.
Wish I could of passed on the Riba but what the hell, it works.
....Kim
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