HCV back 12 week EOT

[Faithdove]

My husband was on Sovaldi, PEGASYS and COPEG for a 12 week regimen. Genotype 1a, and all his EOT were undetectable and now 12 week EOT, it is back. HCV QUANTITATION by RT-PCR 1,770,000.
I am still in shock, and I had to tell him since I got the news first.

[patra_]

My Dr told me, when I asked what my results were, that it did not matter, that was for older meds w/INF bases, that with the sovaldi combos that was not a factor.

Hope this helps.

Pat

[Faithdove]

Thank you for your response, his ALT and AST never fell into the normal range either. Close but not normal. Now they are spiking up again. His next chance for Hope is coming in the mail today. SOVALDI/Olysio .
Praying for you to reach SVR. His new doctor said the IL28B is used to determine poorer response rates in regard to the interferon. I have to go back and ask if is relative to Sovaldi. Maybe someone else on here can help us figure all this poly stuff out!!!! It is a big puzzle to me.

[susan400]

So sorry to hear the news about your husband. I was on the same treatment and my AST never normalized, got lower, but never fell into 'normal' range.  I have shown undetected since week 4 on the tx drugs and the last viral load I had was 1 wk post tx and that one was still showing undetected, but I am not scheduled for another lab until latter Dec. and probably won't hear back on it until everybody returns from the vacation holiday time you, know, like between 12/25 - 1/1.., not much gets done and in my doctor's office, if the doctor hasn't signed off on it and the CMA is also on vacation, you won't get results back until they get back.  Anyway, I want to say that I really feel for you because I've had that very hard news told to me too many times to count!  My doctor never ran the IL28B poly test on me though, because he said it wouldn't change what we were planning to do and since I had decided I wanted to try the Sovaldi, it just wasn't run.  He also didn't run the Q test (that one that checks for resistant to protease inhibitor wild type), or something like that.  Susan400

[Faithdove]

My hubby will now be starting Sovaldi with Olysio on Tuesday. Thank you all for the support! His new doctor also found out why he failed Sovaldi with Ribavirin and interferon. This new doctor is also involved in many clinical trials and really knowledgeable. He falls under the category of infectious disease specialist for HCV and HIV. He failed because in his case, he has the IL28B polymorphism genotype TT. The TT is associated with a poorer viral response in HCV genotype. There may be other factors as well that contributed, but this one definitely lowered his chances.

[Livelife777]

I also am so very sorry the meds didn't reach SVR for your husband.  Can understand your shock and disbelief.   In medicine you can do everything right and fall thru the cracks.   The Drs can't even explain the various reasons for lack of reaching UND12.   As your husbands caregiver you have to know that you did everything right, but the odds were not with him at this time.   Please don't ever feel guilt that if you had done things differently the outcome would have been better as it was sheer misfortune that he did not clear.
You have to always look at the bright side as the new meds coming down the pike will eventually kill and destroy this dreaded virus once and for all.   If you remember just a year or so ago once Tx failed at that time you had no recourse but to hope and pray that the miracle pill would be discovered.  That time has come and we are so lucky to be able to be a part of history in the making.  Please keep the faith, mentally brush it off, and get ready to beat this dragon for good.  
We are all here for you both!
...Kim

[hepc4Sandi]

Hi Faithdove, the list was posted by WyoSue on July 13. I just found it by searching for cure factors sovaldi.

[Verdugo]

Really to sorry to hear the meds failed your husband.  I remember reading his story when I first rejoined the forum back in Dec.   He's had a tough journey but discovering his HCV gives him the upper-hand in the big fight.  As others have posted, help (new drugs) is on the way!

[can-do-man]

Sorry to hear this. with a viral load of over one million don't get your hopes up that the teat was wrong. Many people with a high BMI have cured this it is just a factor they list along with many other things. My guess is it's just Interferon is not his friend. Just don't give up hope as these new treatments are having great results and are without Interferon. Hang in there.

[Faithdove]

Hi all, okay, so I am back to deep diving into this. Maybe our hell will help someone else! I do also recall from some posts or maybe it was a clinical trial cut off for weight, 165 pounds. Trust me, I will find that and let you all know. My husband I'd 5'8" and 216 pounds. As far as compliance to his meds, he took his Sovaldi and the 1200mg of RBV, everyday exactly 12 hours apart, never missing a dose and exactly on time. I was the compliance police. He got his shot every Friday exactly at 6:30 pm each week and I administered the shot. He did everything as prescribed. I am going to ask his doctor today for a retest and also to do a CBC and Chem screen just to see where that is at now. I have all of his bloodwork in a file here at home, because each week if would do a compare and if I felt uncomfortable, I would ask questions. Thank you all again. If anyone comes across that list of cure versus less chance of cure before I do, please let me know. Hugs....

[Idyllic]

I am really sorry to hear this. For both of you. Just based on your posts I know you really exerted a lot of time and energy to learn all you can in a short period of time.  I can just imagine how incredibly disappointed you must be.  Lots of us on here have treated more than once and  I can imagine how drained your hubby must be for all this.

Not sure how soon the next available regimen of meds will be available for Geno 1s but hang in there and keep current on developments and (possibly??) trials.

Take care and keep us informed♥

[Sarah1949]

I am so sorry to hear this. It is sad and also a fear most of us have I think.

[jules2551]

Riba is weight based so not sure that is a major factor

[hepc4Sandi]

I don't know, maybe Sovaldi dosage, there was a list posted a few weeks ago about factors of curing. Look back through the forum, it was if you had over 2 factors the odds went down I think.

[jules2551]

Not sure where the 165# comes into play.  I would think height would be an issue.  Am i missing something here?

Jules

[sue4hula]

I am so sorry to hear this.  What difficult news for both of you.  I am 1a and just finished that treatment.  Your news is my biggest fear.  

I know it means little at this moment, but we can be hopeful and take comfort in the new drugs on the way.

Take time to recover from treatment and this news.  Prayers that we all slay this dragon soon.  

Virtual hugs..

[hepc4Sandi]

I am so sorry to read this, so upsetting, like was said before, at least his liver go a break. Hopefully whatever is on the horizon will work for him. Yes, there was a list a while back about different factors for cure vs no cure, and I think the magic number for weight was 165 lbs.

[Faithdove]

Thank you, I know, at 12 weeks EOT.  And he was finally getting energy back, but like I said above, I did notice some moodiness and that he felt sensitive in the upper right side. He had that horrendous car accident last year, so he has so much scar tissue in his abdomen, hard to figure out what is going on. He also is very overweight, so from much of my reading, I did note someplace that could also make treatment harder. Have you ever heard anything about that, or has anyone else? Sugar is his weakness....

[Faithdove]

Dear Nan!!!! Hi!!!! Yes, his doctor  (gastro) is so upset as well, he is sending my husband to see another doctor that specializes in a Hep C. I didn't even think of asking about having the test rerun, I was in too much shock when I opened the letter from his doc. The one thing that bothered me was that his ALT and AST was never perfect after treatment. Not extremely high, but not in range. Like a foreboding....okay, will ask about a retest, good idea. How is your husband doing? Hugs....

[nursehepc]

I am sure he and you both feel very disappointed. I am sorry. I have no words except that I hope that he and you have strength for another round with meds that have been proven with higher SVR rates for Genotype 1a. Its so hard to hope and wait only to be disappointed. Best wishes to both of you. Jo

[Faithdove]

Thank you for your kind words and prayers. I see on this forum, many folks who have done treatment many times. For my hubby, Sovaldi is not the answer with interferon and Ribavarin for genotype 1a. Guess they will need to revise the treatment recommendations, since that is what it currently recommended for genotype 1a, treatment naive. He did have a few good weeks of virus free but that Ribavirin and interferon kicked his butt.......thank you again.

[patra_]

Oops!  I not only have no memory, I can't read either.  I see he is Gt1a.  

Watch the Led studies. P

[nan535]

I am so sorry to read this. As the caregiver for my husband, it hit me hard because this is what I fear is going to happen to my husband also. Just wondering if they will do a repeat test to make sure the results are accurate?

Our back up plan is Sovaldi/Ledipasvir. I am praying we won't need to go there but since he too is GT1a  I think I need to prepare myself for the news.

Hang in there. The day will come...

Nan

[Faithdove]

Thank you, yes, that is good. We will get there. Just so disappointing. I noticed about 2 weeks ago, he was getting very moody, like he was when he had the virus. He was also complaining that his right side felt sensitive. Signs of the dragons return?????