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HR- Low PH and HCV replication
After reading a study about PH & HCV it seems HCV replicates much faster in someone with a low PH. I suspect that with most people who have a low PH they have a higher VL like myself. Does this make any sense? my urine PH is usually is around 6 or less. If someone was to raise their PH could they lower the VL? is there anyway to raise the PH? thanks for the info
George,
Thanks for that website. It looks very interesting and I'll have a good time exploring it.
I have no science background to speak of and I barely know a thing about ph levels. I just didn't want you to miss anything if it was important. You seem very capable and in charge of your protocol. I sure wish you the best.
Mary,
You are on my prayer list too. My husband was in a trial and failed to meet the two log drop at 12 weeks. Next, he tried Infergen and had a viral breakthrough. I understand the disappointment. I have high hopes for Alinia for all geno 1 nonresponders that can't afford to wait much longer. I have been making a list of all possible helpful adjuncts to SOC that would give that extra edge needed. I've got quite a plan ready if Joe gets a chance to treat again. My master plan kind of scares him but he calls me his medical manager. He does better mentally if he just swallows whatever I give him and thinks about other things. I have become obsessed with killing this virus. I don't know what I would do or think about if he got his SVR and I could go back to normal life. I feel like Monk (The obsessive- compulive detective) searching for clues, except unlike Monk, my house is kind of messy because I spend too much time on the internet in my search. I started out 3 yrs. ago just caring because of my own husband but have since then grown in my heart to care for all the people on this forum that are at war with this enemy. I have never gotten over feeling nervous about posting ( lack of confidence) and I also have a very talkative 4 yr. old making it hard to get my thoughts in order. HR has given us a wonderful fight plan and I am trying to make the most of it. It is easy to forget some of the important things he tells us (much of it goes soaring above my head) but I dig in to get the part that tells me what to do and then I write it down . He seems like a gift from God. I'm generally very disappointed in the way the medical system works but HR has given me more hope. I wonder if the people that come down so hard against supplements/herbs and other alternatives can understand what it feels like to be at stage 4 and a nonresponder to everything the Dr. had to offer. You become more open minded. I know they can be dangerous and can use up a lot of money but that is why I feel so thankful for HR's suggestions. My husband has had a lot more energy, a better color,and less brain fog . I will be excited to see if labs improve in March but even if they don't,his quality of life has improved. I will be watching to see what yummy things you might make with the lemons you recently received. HR's suggestions are like a lovely little open window in a solid brick prison wall.
Best wishes,
Ev.
Thanks for that website. It looks very interesting and I'll have a good time exploring it.
I have no science background to speak of and I barely know a thing about ph levels. I just didn't want you to miss anything if it was important. You seem very capable and in charge of your protocol. I sure wish you the best.
Mary,
You are on my prayer list too. My husband was in a trial and failed to meet the two log drop at 12 weeks. Next, he tried Infergen and had a viral breakthrough. I understand the disappointment. I have high hopes for Alinia for all geno 1 nonresponders that can't afford to wait much longer. I have been making a list of all possible helpful adjuncts to SOC that would give that extra edge needed. I've got quite a plan ready if Joe gets a chance to treat again. My master plan kind of scares him but he calls me his medical manager. He does better mentally if he just swallows whatever I give him and thinks about other things. I have become obsessed with killing this virus. I don't know what I would do or think about if he got his SVR and I could go back to normal life. I feel like Monk (The obsessive- compulive detective) searching for clues, except unlike Monk, my house is kind of messy because I spend too much time on the internet in my search. I started out 3 yrs. ago just caring because of my own husband but have since then grown in my heart to care for all the people on this forum that are at war with this enemy. I have never gotten over feeling nervous about posting ( lack of confidence) and I also have a very talkative 4 yr. old making it hard to get my thoughts in order. HR has given us a wonderful fight plan and I am trying to make the most of it. It is easy to forget some of the important things he tells us (much of it goes soaring above my head) but I dig in to get the part that tells me what to do and then I write it down . He seems like a gift from God. I'm generally very disappointed in the way the medical system works but HR has given me more hope. I wonder if the people that come down so hard against supplements/herbs and other alternatives can understand what it feels like to be at stage 4 and a nonresponder to everything the Dr. had to offer. You become more open minded. I know they can be dangerous and can use up a lot of money but that is why I feel so thankful for HR's suggestions. My husband has had a lot more energy, a better color,and less brain fog . I will be excited to see if labs improve in March but even if they don't,his quality of life has improved. I will be watching to see what yummy things you might make with the lemons you recently received. HR's suggestions are like a lovely little open window in a solid brick prison wall.
Best wishes,
Ev.
I don't test after I take the mixture but rather in the AM before my first dose. As the matter of the salt intake, go to earthclinic.com and read about the science behind the mechanics of sodium bicarbonate and its role in the body.
glad to see you show up even once in a while Evangeline!!!
that's interesting about the low body temp...which I have even on thyroid meds.
but baking soda??????? that's like eating pure salt. actually it is a natural salt, but not one to ingest in quantity.
plus, anytime you test saliva after drinking highly acidic lemon juice you will get a reading that is not reflective of your body chemistry as much as of the remaining acids on your teeth from the lemon juice.
I'll give you a little farm analogy, when we wanted to kill a slug, or kill a plant, we just went out and pour baking soda or salt on it, either one worked......
the only trouble was, once the salt was poured there, nothing would even grow on that soil again, not for many many many years. So great harm was done to the soil, as it can be to a living thing.
So I think you had better listen to Evangeline and HR here, all the old "farmer remedies" were based on folk tales and desperate efforts, and if anyone did spontaneously remit or improve it was attributed to whatever rock or mineral or libation they were trying, regardless of whether there was any real truth or science behind it.
People do go into coma's and die both from too little, and too much of any number of minerals including the essential salts.
Mary.
that's interesting about the low body temp...which I have even on thyroid meds.
but baking soda??????? that's like eating pure salt. actually it is a natural salt, but not one to ingest in quantity.
plus, anytime you test saliva after drinking highly acidic lemon juice you will get a reading that is not reflective of your body chemistry as much as of the remaining acids on your teeth from the lemon juice.
I'll give you a little farm analogy, when we wanted to kill a slug, or kill a plant, we just went out and pour baking soda or salt on it, either one worked......
the only trouble was, once the salt was poured there, nothing would even grow on that soil again, not for many many many years. So great harm was done to the soil, as it can be to a living thing.
So I think you had better listen to Evangeline and HR here, all the old "farmer remedies" were based on folk tales and desperate efforts, and if anyone did spontaneously remit or improve it was attributed to whatever rock or mineral or libation they were trying, regardless of whether there was any real truth or science behind it.
People do go into coma's and die both from too little, and too much of any number of minerals including the essential salts.
Mary.
I remembered reading something negative about ingesting baking soda to alkalanize the body so I googled a little and this is one of the things I came up with.
Quote:
Posted: Fri Dec 07, 2007 2:58 am Post subject: BAKING SODA DANGERS, please be aware
--------------------------------------------------------------------------------
I am a critical care (certified) RN with 24 years experience, during that time I have seen several patients admitted for a high alkalosis condition brought on by regular (daily) ingestion of baking soda. These patients required immediate placement of a breathing tube and mechanical breathing support. The normal pH of the blood is a very narrow 7.35 to 7.45 . This balance is necessary for the proper functioning of all organs (think heart!, brain!), furthermore this balance is delicately managed by the lungs and kidneys and it takes the body far longer to respond to and correct high alkolosis than it does high acidosis. Self correcting pH with fruits and veggies is far safer than by ingesting baking soda in water. Please research for yourselves.
By the way , my husband is a non-responder and is stage 4. I am looking constantly for alternatives but it is like walking through a swamp in the dark with alligators. He has low platelets and some things that are good for his liver ,can negatively impact blood clotting time. He has an esophageal varicies so anything that ups the blood pressure is a big no-no. Tricky to say the least and I am doing my best to be very careful. I have been incredibly thankful for HR's input on these matters. I especially loved the post to Orphan Hawk about some of the less expensive measures because some of this stuff really adds up and we just can't do it. Fruits and vegetables seem to be one of the best things going for all of us.
St george, I don't know if you are a praying man or not but I am praying for you anyway. I hardly ever write in but I read this forum always ,and feel quite close to many of you in your battles with this hateful virus.
Quote:
Posted: Fri Dec 07, 2007 2:58 am Post subject: BAKING SODA DANGERS, please be aware
--------------------------------------------------------------------------------
I am a critical care (certified) RN with 24 years experience, during that time I have seen several patients admitted for a high alkalosis condition brought on by regular (daily) ingestion of baking soda. These patients required immediate placement of a breathing tube and mechanical breathing support. The normal pH of the blood is a very narrow 7.35 to 7.45 . This balance is necessary for the proper functioning of all organs (think heart!, brain!), furthermore this balance is delicately managed by the lungs and kidneys and it takes the body far longer to respond to and correct high alkolosis than it does high acidosis. Self correcting pH with fruits and veggies is far safer than by ingesting baking soda in water. Please research for yourselves.
By the way , my husband is a non-responder and is stage 4. I am looking constantly for alternatives but it is like walking through a swamp in the dark with alligators. He has low platelets and some things that are good for his liver ,can negatively impact blood clotting time. He has an esophageal varicies so anything that ups the blood pressure is a big no-no. Tricky to say the least and I am doing my best to be very careful. I have been incredibly thankful for HR's input on these matters. I especially loved the post to Orphan Hawk about some of the less expensive measures because some of this stuff really adds up and we just can't do it. Fruits and vegetables seem to be one of the best things going for all of us.
St george, I don't know if you are a praying man or not but I am praying for you anyway. I hardly ever write in but I read this forum always ,and feel quite close to many of you in your battles with this hateful virus.
Baking soda at a dose of 1/4-1/2 tsp AM and Pm on an empty stomach with a-2 tsp lemon juice will raise urine, tissue as well as blood ph rather quickly. I have been taking it for about two weeks now and testing my saliva with ph strips and have seen my ph raise from 6 to 7-7.5.
MEDICAL PROFESSIONAL
The ph in our blood and body fluids, with the exception of urine and Gi tract is between 7.38 and 7.42, extremely precisely regulated.
At a ph of 6.3 or 5.5 at our liver cell membrane we have long before gone into irreversible, deadly acidosis.
The kidneys normaly regulate the pH of our blood by excreting protons into the urine ( making it acidic) to the extent needed to keep it at the tight range decribed above.
At a ph of 6.3 or 5.5 at our liver cell membrane we have long before gone into irreversible, deadly acidosis.
The kidneys normaly regulate the pH of our blood by excreting protons into the urine ( making it acidic) to the extent needed to keep it at the tight range decribed above.
Here is some of the study:
Hepatitis C virus glycoproteins mediate low pH-dependent membrane fusion with liposomes.
Lavillette D, Bartosch B, Nourrisson D, Verney G, Cosset FL, Penin F, Pécheur EI.
IFR128 Biosciences Lyon Gerland, Institut de Biologie et Chimie des Protéines, UMR 5086 CNRS-Université Claude Bernard de Lyon.
It has been suggested that the hepatitis C virus (HCV) infects host cells through a pH-dependent internalization mechanism, but the steps leading from virus attachment to the fusion of viral and cellular membranes remain uncharacterized. Here we studied the mechanism underlying the HCV fusion process in vitro using liposomes and our recently described HCV pseudoparticles (pp) bearing functional E1E2 envelope glycoproteins. The fusion of HCVpp with liposomes was monitored with fluorescent probes incorporated into either the HCVpp or the liposomes. To validate these assays, pseudoparticles bearing either the hemagglutinin of the influenza virus or the amphotropic glycoprotein of murine leukemia virus were used as models for pH-dependent and pH-independent entry, respectively. The use of assays based either on fusion-induced dequenching of fluorescent probes or on reporter systems, which produce fluorescence when the virus and liposome contents are mixed, allowed us to demonstrate that HCVpp mediated a complete fusion process, leading to the merging of both membrane leaflets and to the mixing of the internal contents of pseudoparticle and liposome. This HCVpp-mediated fusion was dependent on low pH, with a threshold of 6.3 and an optimum at about 5.5. Fusion was temperature-dependent and did not require any protein or receptor at the surface of the target liposomes. Most interestingly, fusion was facilitated by the presence of cholesterol in the target membrane. These findings clearly indicate that HCV infection is mediated by a pH-dependent membrane fusion process. This paves the way for future studies of the mechanisms underlying HCV membrane fusion.
PMID: 16356932 [PubMed - indexed for MEDLINE
Hepatitis C virus glycoproteins mediate low pH-dependent membrane fusion with liposomes.
Lavillette D, Bartosch B, Nourrisson D, Verney G, Cosset FL, Penin F, Pécheur EI.
IFR128 Biosciences Lyon Gerland, Institut de Biologie et Chimie des Protéines, UMR 5086 CNRS-Université Claude Bernard de Lyon.
It has been suggested that the hepatitis C virus (HCV) infects host cells through a pH-dependent internalization mechanism, but the steps leading from virus attachment to the fusion of viral and cellular membranes remain uncharacterized. Here we studied the mechanism underlying the HCV fusion process in vitro using liposomes and our recently described HCV pseudoparticles (pp) bearing functional E1E2 envelope glycoproteins. The fusion of HCVpp with liposomes was monitored with fluorescent probes incorporated into either the HCVpp or the liposomes. To validate these assays, pseudoparticles bearing either the hemagglutinin of the influenza virus or the amphotropic glycoprotein of murine leukemia virus were used as models for pH-dependent and pH-independent entry, respectively. The use of assays based either on fusion-induced dequenching of fluorescent probes or on reporter systems, which produce fluorescence when the virus and liposome contents are mixed, allowed us to demonstrate that HCVpp mediated a complete fusion process, leading to the merging of both membrane leaflets and to the mixing of the internal contents of pseudoparticle and liposome. This HCVpp-mediated fusion was dependent on low pH, with a threshold of 6.3 and an optimum at about 5.5. Fusion was temperature-dependent and did not require any protein or receptor at the surface of the target liposomes. Most interestingly, fusion was facilitated by the presence of cholesterol in the target membrane. These findings clearly indicate that HCV infection is mediated by a pH-dependent membrane fusion process. This paves the way for future studies of the mechanisms underlying HCV membrane fusion.
PMID: 16356932 [PubMed - indexed for MEDLINE
yes i remember the post and your comments. but with this new study showing a correlation between low PH & HCV replication just wanted your thoughts on it. i have read that viruses, cancer, etc thrive in acidic enviroments as well as low body temps. could it be at all possible? i will try and find the study and post link but i believe it was found that if you raise your PH then the VL goes down.
MEDICAL PROFESSIONAL
This exact question was asked about a year ago and answered in detail, I think it was you who asked. I covered all the background re blood pH and urine pH as is necessary to look properly at this.
In a nutshell, you cannot expect to change your VL by manipulating your urine pH.
In a nutshell, you cannot expect to change your VL by manipulating your urine pH.
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