Harvoni failure?

[48weeks]

I was just curious if any of our regulars have experienced or know of anyone who has experienced a Harvoni relapse or failure. I'm going into week 8 of 12 with good lab results and feeling good.  Again best wishes for all of us against this beast.  

[flyinlynn]

So sorry to read of you relapse.

Were you tested at 12 weeks post treatment? That is considered the test to indicate cured.

Earlier testing at 4 weeks if not detected is a good sign you will make SVR12 at 98.5% correlation. Never heard of a 6 week test just 4 weeks 12 weeks and 24 weeks.

Had you been treated previously?

I also failed 3 treatments with interferon based treatment and a 12 week treatment with Sovaldi and Olysio where I was not detected at EOT but was found to have relapsed 12 weeks after I finished treatment so I totally understand your disappointment,. I was devastated when I found out I had relapsed.

Just know there are new treatments coming next year that may be able to help the treatment failure from this generation of medicines we have now.

Good luck to all

[smmace01]

I am a GT 1, little cirrhosis. I took Harvoni for 3 months (per Doc) and was undetectable VL after 6 weeks.  Stayed that way until about the 5 month.  At the point I relapsed.  First treatment, obtained HCV in the early 80's.  Not sure what will be done at this point, but waiting for another drug to come back b/c the expensive blood test indicates Harvoni wont work on me.  Lots of $$ spent for a year to have this happen. :(

[darbara]

sorry to hear this I am on the same treatment and similar stats like you, this does scare me

[failedharvoni]

I also failed 12 weeks of Harvoni, I couldn't beleve it. I didnt know how bad I felt until I was on Harvoni and all labs normal.  
SVR< 15.
4 weeks EOT treatment it was back with a vengeance.
Started as:
Treatment naive.
GT1a
lowest level of compensated Cirrhosis.
1986 blood transfusion.
I am losing hope.
#HateHCV

[flyinlynn]

I saw some real world reports recently that 12 weeks of Harvoni with Ribavirin is having a few percentage points higher SVR12 rates than 24 weeks of Harvoni alone for prior null responders with cirrhosis. If memory serves I believe it was like 97% vs 92%

So glad I asked my doctor about adding Ribavirin to my treatment. I got the Ribavirin part way in so I took 24 weeks of Harvoni and 14 weeks of Ribavirin  

Best wishes to all
Lynn

[darbara]

did you take ribavarin with your treatment ?