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479244 tn?1271563659

IDEAL study

Does anyone know anything about the IDEAL study?  This is where I think the info came from regarding my original decision to go with the pegintron.... less relapse rate, less sides, stays in system shorter amt. of time when you come off , etc.

My new nurse, said that study had a lot of flaws and she did not put a lot of faith in it and talked me into pegysus...

any comments would be  appreciated.

bandman
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479244 tn?1271563659
anybody?
Helpful - 0
479244 tn?1271563659
just found this ... pretty interesting commentary by Dr. Dietrich regarding the IDEAL study.
read the whole thing.
bandman
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479244 tn?1271563659
oops , forgot the link:

http://www.natap.org/2008/HCV/011408_02.htm

bandman
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Avatar universal
1. pegasys and pegintron had essentially the same performance in their clinical trials
for FDA approval. those numbers are fairly scientifically meaningful. your choice of one or the other doesnt really change your odds.

2. some tough case patients respond to one better than the other. this info can only be obtained for you as an individual by treating and failing and then trying the other one and succeeding.  still not helpful info for others, it only applied to you and cant be determined before treatment.

3 the docs who like pegasys like it because its generally easier on their patients.
this idea is generally agreed upon in the hep community.
the docs who like pegintron like it because they figure if it gives more side effects
it must be 'stronger'. the scientific evidence does not back this up.

4. this is the only meaningful distinction between the two.
it is based on the generally accepted notion that larger doses give more success.
(also more side effects and problems)

if you are a large heavy person go with the weight based pegintron
as you will  get a bigger dose per pound than with pegasys.
if you are a tiny person in the 100  to 120 lb range you should take
pegasys as you will be getting a bigger dose per lb because
pegasys is not weight based and everyone gets the same dose.
do not try to compare the actual dosing numbers (e.g. 150 mcg) as they are two completely different concoctions. even though the dosing amounts are similar
they are still like apples and oranges.

Helpful - 0
479244 tn?1271563659
thanks cruelworld!

I weigh 156 - so she wants to go with the pegysys, for exactly the reasons you mentioned.

bandman
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Avatar universal
But why not just use the correct dosage of Pegintron? Or, if there is any question, a slightly higher dosage.

Pegintron is very flexible with the dosage options.
The thing I can't figure out is why there are no dosage recommendations or references to the 1/2 stops on the redipen. There are 5 stops but the literature never suggests using the stop between say .4 and .5 ml for someone who might be right on the cusp of the weight recommendations.

My Dr. prescribed .4 ml for me even though I was technically 4 lbs over the cutoff point.
(169 lbs - 120mcg redipen)
But rather than recommend that I use the stop in between .4 and .5 ml he chose the lower dosage for my body weight.

Consequently I did not clear.

Helpful - 0
96938 tn?1189799858

"The thing I can't figure out is why there are no dosage recommendations or references to the 1/2 stops on the redipen. There are 5 stops but the literature never suggests using the stop between say .4 and .5 ml for someone who might be right on the cusp of the weight recommendations."

For the same reason that ready-to-wear clothing comes in sizes 32, 34, 36, etc.  The in-betweeners need to suck it in or wear it loose.

Similar:
'tighten the bolt finger-tight'.  Who's fingers?
Helpful - 0
479244 tn?1271563659
thanks guys....

that is what my pegintron friend is saying.... if you start to lose weight , just adjust the dose.

bandman
Helpful - 0
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