"...how did they come up with the proper dosage to overcome the virus..."
They haven't. Everyone is different - all they've come up with is the dosage that the average person can tolerate.
How'd they do that? Probably the way they usually do - trial and error
hmm - I think this would be a hard thing to quantify. As pointed out in the above study a lot of cell types, not just immune cells, will express various ifn a/b genes when RNA virus is detected and some of this is intended to diffuse to neighboring cells.
The average number of ifn molecules in the nucleus of hepatocytes with/without tx might be a good indicator, but am not sure how one might measure that.
"180" = 180 micrograms .00018 gram
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2193578
One out of 1000 of your PBMCs are natural IFN alpha producing cells. An NIPC can produce 10 picograms of IFN alpha .00000000001 gram when exposed to viruses or bacteria.
Me thinks the "big guys" know that answer...and only them.
Very interesting question, I hope we hear some answers. Sounds like an HR question, doesn't it, but we don't see him round these days...
Interesting question... I wonder if there are any answers out there