Peter don't be discouraged, a lot of us cirrhotics have gained SVR. You have to play by the rules they set out... I wish you the very best.
I am not certain about the weight loss but I just want to congratulate you for getting your BP under control. This is likely one of the more stressful events you will probably experience in your life yet you have managed to obtain a very healthy BP. That is not an easy thing to do so my hat is off to you.
First, congratulations on your weight loss. That is a big accomplishment.
Unfortunately weight is not a major pre-treatment factor in the treatment of hepatitis C with persons with cirrhosis unless you have fatty liver disease also. The stage of liver disease is THE most impact of any factor in the ability to achieve SVR. Which is why it is so difficult for persons with cirrhosis to achieve SVR.
Of course reduction of viral load over time is the largest on treatment predictor of SVR. The quicker you become undetectable the better the odds of SVR. Your viral load dropped over 2 log so you have responded well to the treatment. When did your viral load become undetectable? Week 8 or week 12?
Let me encourage your weight loss success. The healthier you are generally the better you will be able to handle all of your health issues including the progression of your liver disease and should you achieve SVR the healing of whatever hepatocytes are still remaining in your liver. I believe you are still "compensated", which is excellent, and you should want to stay compensated as long as possible. It sounds like you are taking care of yourself and are living a healthy lifestyle. Glad to hear you have been able loss that extra weight. I'm sure you feel better physically now too except for treatment side effects.
Best of luck with your treatment!
Hang in there.
The last time I had my viral load tested before treatment, it was at about 2,400,000.
My viral load was down to 44 after 4 weeks, and "negative" or UND after 8 weeks.
I have been at stage 4 cirrhosis since 2004, it is compensated and hasn't seemed to become any worse since then. The chances of SVR are of course reduced because of my cirrhosis, but I have seen on this forum people who were at stage 3 and 4 who attained SVR, so I'm still hopeful.
May I ask what genotype you are and since your a prior relapser on SOC how they came up with a 34 week treatment?
I was Dx in 2005 with cirrhosis, relapsed but now SVR so yes it can be done............ Best to you.
Sorry meant 24 week treatment.
I'm genotype 3a.
Although I relapsed after rebetron in 2003, it may have been because I temporarily stopping the treatment (interferon for a week, ribivirin for several weeks) at about the 15th or 16th week - because I could not function at work during an unusually hot summer with the severe fatigue.
I went from UND at 12 weeks (they didn't test at 4 or 8 weeks) to "positive" at about 18 weeks. After resuming the ribivirin, I was UND again at 24 weeks and then the virus was detected again 4 weeks after end of treatment.
I'm a little bit confused, usually a 3 will do SOC for 48 weeks if they relapsed...regardless of why. You know 3 can be as tough sometimes as a geno1, right?
This time I've taken time off work until the end of treatment. My 24 weeks will be completed by the time the really warm weather arrives in late June and July.
I'm finding the fatigue and other side effects (such as dry mouth and headache) much easier to deal with since I'm relaxing at home rather than trying to function and keep up with the others at work.
So glad to hear that you can stay home with this tx. It is tough. I also had dry mouth and used all the Biotene products, also sour candy helped with the bad taste, wishing you the best.
The doctor thinks 24 weeks will be okay because I stopped treatment for a time in 2003 due to severe fatigue and being unable to function at work.
However, I think 30 weeks would be better. For people with genotype 3 who have cirrhosis, it takes a few weeks longer to attain SVR.
I've seen the results of studies/trials that show with genotype 3 and cirrhosis stage 3/4, the SVR rate is very low after 16 weeks, but for people with no cirrhosis about 75%-80% not much different than for 24 weeks.
But those trials showed there's a BIG difference in SVR rates between treatment of 16 and of 24 weeks for people with genotype 3 and cirrhosis stage 3/4 (although still much lower than the SVR rates for people with no cirrhosis).
So that may imply although I might not need 48 weeks (which would be impossible anyway because I'll need to work) 30 weeks might be better than 24 weeks. I've asked about this but they say they cannot extend treatment for 4 more weeks.
That your viral load was undetectable at 8 weeks is great. So you probably became undetectable somewhere between weeks 4 and 8. That is the biggest factor in the success of treatment, even beyond cirrhosis. It is the viral load kinetics that matters the most. So things look very good. Remember to stay compliant with your drugs and hopefully you won't need to reduce your dosages. When taking only two drugs for treatment dose reductions or stoppage, as in your previous treatment, can allow the virus to return.
Odds of successful hepatitis C are very different between stage 3 and stage 4, which is why we encourage anyone who has stage 3 liver disease to treat before they progress to Stage 4, cirrhosis.
Best of luck with your treatment!