Hepatitis C Community
13.4k Members
Avatar universal

Is there a test for ITPA?

I just read that inosine triphosphate pyrophosphatase (ITPA) deficiency is a clear risk factor for early onset of anemia during HCV treatment, necessitating that ribavirin be reduced or discontinued.

The article I read was dated June 2010 and said there is no test for ITPA but that there likely would be soon.

Does anyone know if a test has been developed or if there is any way to factor this variable in when choosing a treatment?


Beat the Beast
2 Responses
179856 tn?1333550962
No most of us would not be concerned with such a thing as so I dont know if anyone has ever looked into such a thing. Seriously this would not be a major cause of concern for me if I was just starting out on treatment - there are other variables that are proven to be valuable but this wouldn't even be on my radar as an option.
233616 tn?1312790796
the best way to avoid pernicious anemia is to have protein in your diet, but the anemia associated with hcv treatment is hemolytic anemia, not enough red cells, and this is because the riba is killing the red cells, it can kill the white cells and platelets can also drop.  The combo of riba?INF does a number on all blood components although hemoglobin is hit the hardest most often.

You do want to keep inosine in your diet, but you might be better to include proteins in the meals that don't include your riba.
You need protein also for B12 levels to be good, and you can't build new blood without that.
However, in early treatment riba has trouble getting to therapeutic levels, and so I have a thread on PURINES and riba absorption which explains how one might increase riba levels.
My though is to include proteins in 2 meals a day, but not the riba meal/snacks.
Just read the thread and all will become clearer.

Have an Answer?
Top Hepatitis Answerers
317787 tn?1473362051
683231 tn?1467326617
Auburn, WA
Learn About Top Answerers
Didn't find the answer you were looking for?
Ask a question
Answer a few simple questions about your Hep C treatment journey.

Those who qualify may receive up to $100 for their time.
Explore More In Our Hep C Learning Center
image description
Learn about this treatable virus.
image description
Getting tested for this viral infection.
image description
3 key steps to getting on treatment.
image description
4 steps to getting on therapy.
image description
What you need to know about Hep C drugs.
image description
How the drugs might affect you.
image description
These tips may up your chances of a cure.
Popular Resources
A list of national and international resources and hotlines to help connect you to needed health and medical services.
Here’s how your baby’s growing in your body each week.
These common ADD/ADHD myths could already be hurting your child
This article will tell you more about strength training at home, giving you some options that require little to no equipment.
In You Can Prevent a Stroke, Dr. Joshua Yamamoto and Dr. Kristin Thomas help us understand what we can do to prevent a stroke.
Smoking substitute may not provide such a healthy swap, after all.