Geno 1, taken off Pegasys at 24 weeks after viral breathru, went from 2 log drop at 12 weeks to BIG rise at 24 weeks. Small town doc sending me to Hepatitis Clinic at U of W, am wondering what medical protocol is for next round of tx? Biopsy in 2003 showed bridging fibrosis, 22 million viral load. After stopping tx, ALT stayed low until year ago, now rising and have ribcage ache, BAD fatigue, etc. Am going nuts wondering what protocol says is next, small town doc didn't want to do maintenance, says off label. Depression under control, but WAY worried about Infergen, is it as tough as people say? I had a hard time on Pegasys, lost 50 lbs and stopped eating, constantly sick to my stomach. Now, ALT at 130 and thyroid T3 uptake is very low. Any hints on what course the clinic may want me to take? Long question, big problem, bad, bad virus. Man, I am so sick of feeling bad. Oh, and I am a gramma too.