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Is this for real or total tomfoolery? Oral Immune Modulation technology

Immuron To Acquire Intellectual Property from Hadassah Medical Center
Immuron introduces an Oral Immune Modulation technology acquired from Hadassah. Technology could yield within 2-3 years an all- natural, side effect free approach to diseases including Metabolic Syndrome, Hepatitis C and Type II Diabetes.

FOR IMMEDIATE RELEASE

PRLog (Press Release) – Apr 19, 2009 – NEW YORK and MELBOURNE. Immuron (ASX: IMC), a biopharmaceutical company, today announced an agreement to acquire a novel Oral Immune Modulation technology from Hadasit, the commercialization arm of Hadassah Medical Center in Israel.

The combination of oral immune modulation with Immuron’s existing oral protein and antibody technology could yield a convenient, all- natural, side effect free approach to address serious diseases which have multi-billion dollars markets, including Metabolic Syndrome, Hepatitis C and Type II Diabetes.

Hadassah Medical Center scientists have demonstrated that their oral immune modulation approach, used in combination with Immuron’s own dairy  derived antibodies and other proteins, can directly affect the activity level of regulatory T  cells, a type of immune cell known to have profound  effects in controlling the inflammation in many diseases. This novel approach has shown positive effects in several validated animal models of human disease, including type II diabetes and metabolic syndrome.
Immuron will focus its initial clinical development effort with this platform technology on three major diseases having inadequate medical therapy now: Metabolic Syndrome, chronic Hepatitis C (HCV) and Liver Cancer (hepatoma).  These conditions represent major pharmaceutical market targets in industrial and developing countries, and can have severe consequences for affected patients.
Immuron intends to initiate clinical trials for metabolic syndrome and HCV shortly after the acquisition. Given that the products are intended to be marketed as a Medical Food in the United States (and under similar classifications in other countries), it is expected that Immuron can introduce commercial products for some indications shortly after such trials, potentially within 2-3 years.
The new platform technology will also provide an additional layer of patent protection to strengthen the existing Immuron pipeline products (which target Traveller’s Diarrhea, HIV/AIDS immune depletion, Mucositis and Influenza).
The Metabolic Syndrome is defined as a combination of abdominal obesity, hyperlipidemia and insulin resistance. Insulin resistance is associated with a constellation of common clinical conditions, including type II diabetes, obesity, hypertension, and hypertriglyceridemia. It is estimated that up to 25% of the western population have manifestations of this disorder. An analysis by Medco Heath solutions claimed that the average yearly US pharmacy cost of treating adult patients with Metabolic Syndrome exceeds $4,000 per patient - more than four times the average annual drug spend for all other patients.  With more than 45 million Americans affected by metabolic syndrome the target market is large.  
Non-alcoholic steatohepatitis (NASH) is a condtion which considerably overlaps Metabolic Syndrome at the immunological level, and is one stage on the spectrum of non-alcoholic fatty liver diseases. It is estimated that 8.6 million obese adult Americans may have NASH and about 30.1 million may have the milder steatosis. Since no effective medical therapy is currently available for patients with non-alcoholic fatty liver diseases, Immuron will also address this clinical target.
Hepatitis C virus (HCV) infection affects about 2-3% of the world’s population (170 million people) and in the USA alone between 3-4 million people have chronic HCV infection. Patients with chronic HCV infection are at high risk for developing cirrhosis of the liver, end stage liver disease, or cancer. There are emerging immunological linkages between Hepatitis C and type II diabetes.

In addition to the acquired Intellectual Property, Hadasit will provide discounted clinical and laboratory services to Immuron, providing Immuron with efficiencies in its cost structure for human clinical trials.  In return, Hadasit shall be issued 19.99% of Immuron’s equity at the time of the approval of the transaction by Immuron’s shareholders, as well as royalty on selected Immuron products.  A special meeting of Immuron’s shareholders will be called during May this year to approve this share allocation.
As part of its due diligence, Immuron commissioned Biocomm Squared (Biocomm2), to assess the scientific and economic foundation of Hadasit’s Intellectual Property (IP). The full report prepared by Biocomm2has been lodged at ASX in conjunction with this announcement and is available on Immuron’s web site: http://www.immuron.com  
Professor Yaron Ilan from Hadassah Medical Center, a recognized world expert on oral immune modulation, will become the Medical Director of Immuron. Prof. Ilan will continue to serve simultaneously as the Director of the Department of Medicine A and the Deputy Dean of the Hebrew University-Hadassah Faculty of Medicine.
Dr. Zeil Rosenberg, CEO of Immuron, noted “This transaction marks a turning point for Immuron in its quest to lay a firm scientific foundation for its own technology to address large unmet medical needs”

Dr. Rafi Hofstein, CEO of Hadasit noted “ Hadasit is happy that its discoveries can move so quickly into commercial partnership. Our world class clinical experts are ready and able to get the high quality clinical data needed to bring this biotechnology innovation to patients.”

Dr. Oren Fuerst, Head of Business Development at Immuron noted “ The Hadassit technology  provides Immuron with the ability to address several of the largest markets in the healthcare sector- Metabolic Syndrome, Diabetes, Hepatitis C, Hepatitis B and HIV. This transaction can generate large value for shareholders and helps position the company for profitable commercial partnerships with large pharmaceutical and consumer health companies .”

About Immuron

Immuron Limited (www.immuron.com) (IMC.AX ; OTCQX: IMROY) is a biopharmaceutical company focused on oral immunotherapy using colostrum-derived health products. Immuron’s antigen-primed antibody manufacturing technology enables it to rapidly develop polyclonal antibody and other protein-based oral therapies to a range of important infectious and immune- mediated diseases, including Metabolic syndrome, Influenza, cancer therapy-related GI tract Mucositis, and HIV/AIDS related immune activation.

About Hadasit

Hadasit ( www.hadasit.co.il ), the Technology Transfer Company of Hadassah Medical Organization (HMO) in Jerusalem, Israel, promotes and commercializes HMO's continuously generated intellectual property (IP) and R&D capabilities. IP generated by HMO has already gained global recognition due to Hadasit's successful enterprising of Hadassah's biomedical technology, including novel therapeutics, diagnostics and devices.
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Immuron Limited (www.immuron.com) (IMC.AX ; OTCQX: IMROY) is a biopharmaceutical company focused on oral immunotherapy using colostrum-derived health products. Immuron’s antigen-primed antibody manufacturing technology enables it to rapidly develop polyclonal antibody and other protein-based oral therapies to a range of important infectious and immune- mediated diseases, including Metabolic syndrome, Influenza, cancer therapy-related GI tract Mucositis, and HIV/AIDS related immune activation.

1 Responses
Avatar universal
What the heck is this oral immune modulation technology? Is it plain malarkey? I'm feeling too impaired today to understand it.
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