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1853014 tn?1340042175


Got my lab results back and hope everyone can be of some help.
HCV Fibrosure   stage: F1-F2   score: 0.34
TSH 1.05

Docs notes states he will check Fibrosure test to see if this returns abnormal.  My question is what what is he looking for to be abnormal?

5 Responses
Avatar universal
Hepatitis C Virus (HCV) FibroSURE

    Clinical and Interpretive
    Fees and Coding

LIS Resources

    Setup Information:
    Excel | PDF
    Sample Report
    Setup Reference Guide

Useful For

Assessment of Liver status following a diagnosis of HCV. Baseline

determination of liver status before initiating HCV therapy. Post-

treatment assessment of liver status six months after completion of

therapy. Non-invasive assessment of liver status in patient

who are at increased risk of complications from a liver biopsy.
Reference Values

TESTS                         REFERENCE INTERVAL

HCV FibroSURE Results:

Fibrosis Score                                      0.00 - 0.21

Fibrosis Stage

Necroinflammat Activity Score               0.00 - 0.17

Necroinflammat Activity Grade


Alpha-2-Macroglobulins, Qn                   110 - 276           mg/dL

Haptoglobin                                            34 – 200          mg/dL

Apolipoprotein A-1              Females:     110 – 205          mg/dL

                                          Males:        110 – 180          mg/dL

Bilirubin, Total

                                                     Newborns, term and near term:

                                                        24 hours old:  0.0 –  8.0 mg/dL

                                                        48 hours old:  0.0 – 12.2 mg/dL

                                                        72 hours old:  0.0 – 15.6 mg/dL

                                                        96 hours to 1 month old:  0.0 – 1.2 mg/dL

                                                      Children 1 month and older and

                                                      Adults:  0.0 – 1.2 mg/dL

GGT                                       Females:             0 – 60   IU/L

                                              Males:                 0 – 65   IU/L

ALT (SGPT)                            Females:              0 - 40   IU/L

                                              Males:                 0 – 55   IU/L


Quantitative results of 6 biochemical tests are analyzed using a

computational algorithm to provide a quantitative surrogate marker

(0.0-1.0)  for liver fibrosis (METAVIR F0-F4) and for

necroinflammatory activity (METAVIR A0-A3).

Fibrosis Scoring:

           0.74 = Stage F4 – Cirrhosis

Macroinflamm Activity Scoring:

              0.62 = Grade A3 – Severe activity


The negative predictive value of a Fibrotest score 0.48 (F2, 3, 4) was 61% in that same patient

cohort.  HCV FibroSURE is not recommended in patients with

Gilbert Disease, acute hemolysis (e.g. HCV ribavirin therapy

mediated hemolysis),  acute hepatitis of the liver, extra-hepatic

cholestasis, transplant  patients, and/or renal insufficiency patients.

Any of these clinical situations may lead to inaccurate quantitative

predictions of fibrosis and necroinflammatory activity in the liver.


The performance characteristics of this test have been

determined by LabCorp. This test has not been cleared or

approved by the U.S. Food and Drug Administration (FDA).

The FDA has determined that such clearance or approval is not

currently required. LabCorp is regulated under the Clinical

Laboratory Improvement Amendments of 1988 (CLIA)  and is

certified to perform high complexity testing.

Results and Interpretation Provided By:

Lab-Corp RTP

1912 Alexander Drive

Research Triangle Park, NC 27709

Test Performed By:      Lab-Corp Burlington

                                   1447 York Court

                                   Burlington, NC 27215-2230    
789911 tn?1368640383
within 2 years I  had 3  hepa-score by Quest and one Fibrosure by Labcorp.  My results in the beginning were F-0 F-1 with Quest. Then I had the Fibrosure came back F-4 cirrhosis. Then the final Hepascore came back F-2.  From the date of my diagnosis in 09 until Feb 2011, I had these done approx every 6 months.  I finally got a biopsy in March 2011 right before I started treatment and it came out F2.    The blood markers are not  that reliable sorry to say.   Neither is anything a for sure bet, but the biopsy is still more reliable.  I didnt look at your status to see for any prior posts about your treatment history, but if you are on the fence between a 1 and 2.  It is getting  near the time to start treatment.  Best Wishes
789911 tn?1368640383
I would also add that if you cant have a biopsy for medical reasons, then yes, by all means the fibrosure/hepascore  and or catscan would be the alternatives to get some info on the condition of your liver.
789911 tn?1368640383
ok I see you are getting ready to start treatment!  Im so glad for you and wish you the best.  One thing is a lot of people who cure the HCV also can turn back  their liver damage a stage or two!  
1853014 tn?1340042175
thanks so much there is still no much confusion about everything but getting better and better with everyones help and sometimes overwhelming.
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