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7510956 tn?1411671417


Today I received my lab work and it showed my platelets came down to 115. I wanted to know if they can be this low without Cirrhosis?.    
11 Responses
446474 tn?1446347682
Of course there are many medical illnesses and conditions that can cause thrombocytopenia las with all blood level abnormalities.

Also hepatitis C treatments that include interferon products will reduce platelet count as one of its side effects.

Low platelet counts are a common complication of cirrhosis. As cirrhosis advances, portal hypertension increases, which causes a reduced platelet count as one of its many complications.

A serious problem for people with cirrhosis is an increase in pressure in the blood vessels that flow to the liver. Normally, blood from the intestines and spleen is pumped to the liver through the portal vein. But in cirrhosis, this normal flow of blood is slowed, building pressure in the portal vein (portal hypertension). This blocks the normal flow of blood, causing the spleen to enlarge (splenomegaly). As the spleen enlarges, it traps more than a normal amount of platelets. (The amount of platelets in the bloodstream is thus reduced because the larger spleen traps more of them). The blood is frequently “shunted” around the liver to return to the heart by smaller vessels, which may become enlarged. In the stomach and esophagus these engorged blood vessels are termed “varices” and are at increased risk of bleeding, which is another major complication of cirrhosis.

So typically---people with cirrhosis end up having a problem with portal hypertension, an enlarged spleen, and a reduced platelet count in the bloodstream.

A platelet count of 115,000 is not very low for someone with cirrhosis. 150,000 is the common low end of the lab range. Commonly class A, compensated cirrhotics with portal hypertension have platelet counts in the 50,000 - 80,000 range. Many of us have lived many years with platelet counts half of your current platelet count. It is only when the platelet count is below 20,000 that it can become dangerous although different doctors have different comfort ranges. Of course your liver specialist should be watching for any resulting coagulation issues for anyone with cirrhosis. Should your liver disease continue to advance, coagulation issues can become a concern along with all of the other complications of advanced cirrhosis and should be monitored and managed accordingly.

The first noticeable signs of coagulation problems may be easily bruising and nose bleeds that can take many minutes to stop bleeding. Sometimes bleeding gums can also arise.

Of course you should never take NSAIDs or other medicine that can further reduce blood clotting or can cause internal bleeding. The only safe analgesic for someone with cirrhosis is Tylenol/Acetaminophen. Your liver specialist who has your medical data is the best source of information on your cirrhosis and itd impact on your health.

Good luck.
317787 tn?1473358451
Hi there Fred, Hector has given you excellent advice.
Many people have lowered platelets while on tx.
Yours are not bad for someone on tx.
Your doctor will let you know if there is any cause for concern.
During my first tx they said they would allow it to get as low as 55 before reducing my riba.
Hang in there!
7510956 tn?1411671417
I am currently on S/O and will be tested in 3 weeks to see if the meds are working for me. Doc said not to worry since  there are  better meds coming out sooon if this treatment does not work but I sometimes feel like time is running out. When I saw the plat were lower I got a bit more concerned. Thank you both for your post.
Avatar universal
F:  Please listen to them - they know what they are talking about!  Also, don't get discouraged because hyour doctor said there were new, better meds coming - he (she) was trying to encourage you.  Basically s/he is right, but to spell it out, treating now, can put you as Undetected, and, then, even if you do relapse and need the new treatment(s) YOU HAVE GIVEN YOU LIVER A REST, and, at the worst, bought your liver some more time to get to the new meds and SVR,IF you don't achieve it now

My dr said the same thing - need to treat now (F-3, A0/A1). BECAUSE many people ARE SVRing on these treatments, BUT, this way, we have a back up plan!

Wishing you SVR now, and all the good things that go with it.  Hwr, isn't it nice to know that you are still helpimg your liver now And have a back-up plan, if you need it?  Pat

On to SVR, everyone!!        
Avatar universal
Hi there
Understand your concern as I also was worried about my platelets in regard to Tx.  There is no significance as to what your platelets are showing during Tx.  They can go up, down, or everything in between while treating.  The true number of your platelet count is the # that you started prior to Tx.  Once you end Tx, your platelet count will go back to the original # 12 weeks post.
When I started Tx in Jan, my platelets were 125.  While on Riba and Sovaldi for 12 weeks they were 250, 280, ect.  The Riba makes the #s go up instead of down, opposite of Oyslio I imagine.  When I was SVR12 my platelets went back down to my original starting point 118 after curing.  ( Give or take a few points). I panicked since I had become cured, why did they go down?  Did my research and found that on Tx the #s are not the real #s or indicative of my liver status.   BTW I am like you, also early or mild cirrhosis.
Wow!!!!!    Hope you got all that!   Now I am 5 months since EOT and do know my liver is regenerating.   Yes regenerating!  My blood work is perfect and I feel great.  When I go for my scan in Dec I believe it will show stage 2 or less.   My Drs at Mayo Clinic agree.  Don't believe this is wishful thinking.
Sooooooo.  Keep doing what your doing and don't worry what #s show in your bloodwork while Tx.  If something were to pop up that's worrisome your Drs should be on top of the situation.  Must say that I hope you can get a clearence, but if not, your liver has been given a break from the viruses deadly grip.  If this go round doesn't work, the next one will.   We are on the verge of eradicating this deadly virus for good.
Take care and be well
Avatar universal
Hi, my platelets were normal before treating with Sovaldi Olysio, they lowered while on treatment, and I'm over two months out of treatment, and they are still at 116, which my doctor told me not to worry about. That's still not particularly low. While I was taking chemotherapy they went down to 10 (I had to be transfused at that point) so you can imagine. Hopefully, I will SVR and they will pop up as I go along. But the116 I can live with.

Livelife777...I am so happy to read your post. Need some happy news this morning!
Avatar universal
Also, forgot to say, I have low liver damage at 1 from my biopsy.
7510956 tn?1411671417
what is low liver damage of 1, is that like the F1 ?
Avatar universal
guys am sorry but if someone can explain me what is the chance to get hepatitis C from sex ? i hope everyone on this side ia gonna feel betther
683231 tn?1467323017
Hi Frank

Probably better if you had started a new question by clicking orange link at top right of page but anyway:


Hepatitis C (HCV) is spread through contact with an infected person’s blood -- which may be present because of genital sores or cuts or menstruation. HCV has been detected with greater-than-average frequency among people who have a history of sexual promiscuity -- which can be defined as a history of a sexually transmitted disease, sex with a prostitute, more than five sexual partners per year, or a combination of these. A person who is in a long-term monogamous relationship with an HCV-infected person rarely contracts this virus. Only approximately 2% of sexual partners of HCV-infected people also test positive for HCV. However, it is important to note that this statistic is based on indirect evidence only. Therefore, whether these people became infected through a sexual act or by another route is unclear. For example, people in long-standing relationships generally care for one another in times of illness or injury. During such times, HCV may be transmitted to the spouse or partner, because the couple may not be as cautious about avoiding contact with blood.

hope that answers your question if you would like to ask another question please post a new question

Good luck
683231 tn?1467323017
I just noticed you already asked the same question on 9/16

The answer is the same relatively low risk unless multiple sex partners and engage in rough sex.

Always best to use protection if not in a long term monogamous relationship.

If in doubt, get tested, get treated, get cured.
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