I think the procedure is sometimes super easy, and sometimes not so easy, but it isn't totally predictable. Mine went fine, with no complications, and yet it was tender for a while. I had to be pretty inactive for two days and then careful for about a week. I continued to have slight tenderness in the area for many months. I think that most people here experienced less discomfort than I did however, as I've heard many write about it as if it was no worse than getting a flu shot. I think you should be prepared to need several days but hope you are one who bounces back in hours. Good luck!
I say give yourself at least 3 days or 4 I took only a day went back to work and re injured myself. So take all the time you need.
The worst part of the biopsy is the worry before hand as its really not to bad, I would plan on taking the day after off as you might be a little sore. They also say one should not lift I believe over 10 lbs for a few days, other then that its pretty cut and dry... The worst part for me was having to lay still for a couple hours afterwards before I got to go home........ Best to you.