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Lobu-what-is?

on my liver biopsy it says "spotty chronic lobulitis" no matter where I look though I can't find out what that means.  I plan to see my doctor, just confused until then.  Also I still don't get what exactly "fibrosis" is.  And my "portal inflamation" is "moderate" whatever that means.  damnit it's 2am and I just can't sleep with this stuff on my mind.

4 Responses
476246 tn?1418874514
Fibrosis is scarring of the liver. Sorry I can't help you with the spotty chronic lobulitis. As to your biopsy results neither...

But if you want to know what Hep C does to the liver, watch this presentation by Dr. Dieterich. It starts with an animated video were you can follow what happens.


http://www.mssmtv.org/player_alf/player.php?id=alf_2007_01

Marcia

I really hope you got some sleep
408795 tn?1324939275
I think it may have something to do with fibrosis and/or diabetes.  I'm just giving you a quick glance guess and an article to read.  You can Google it or go to pubmed, I'm sure someone will chime in later with a better answer.  God Bless

"Diabetic mastopathy," or sclerosing lymphocytic lobulitis, is strongly associated with type 1 diabetes.
Kudva YC, Reynolds C, O'Brien T, Powell C, Oberg AL, Crotty TB.
Division of Endocrinology and Metabolism, Mayo Clinic, Rochester, Minnesota 55905-0001, USA. kudva.***@****

OBJECTIVE: To demonstrate the strong association of diabetic mastopathy or sclerosing lymphocytic lobulitis with type 1 diabetes mellitus by studying appropriate control groups and to describe risk factors and natural history of the disorder. RESEARCH DESIGN AND METHODS: This was a retrospective cross-sectional study of four groups of patients conducted at a setting tertiary care medical center. We examined benign breast biopsies (investigator masked to identity) from age-matched patients with types 1 and 2 diabetes, autoimmune thyroid disease, or none of the above disorders for sclerosing lymphocytic lobulitis. Several risk factors proposed for the disorder (age at diagnosis of benign breast disease, duration of diabetes, age at onset of diabetes, prevalence of retinopathy, neuropathy, nephropathy and cheiroarthropathy, glycemic control, parity, oral contraceptive use, menopausal status, or number of breast biopsies) were evaluated, and patients were contacted to describe the natural history of the disorder. RESULTS: Sclerosing lymphocytic lobulitis was identified in 69.7% of the subjects with type 1 diabetes and 1.8% of those with autoimmune thyroid disease diagnosed with benign breast disease at surgery. It did not occur in patients with type 2 diabetes with or without insulin treatment or in control subjects. Only retinopathy and peripheral neuropathy were associated with sclerosing lymphocytic lobulitis. Breast carcinoma or lymphoma did not occur subsequently in any type 1 diabetes patient with or without sclerosing lymphocytic lobulitis. CONCLUSIONS: Sclerosing lymphocytic lobulitis is strongly associated with type 1 diabetes. Retinopathy and neuropathy are associated with the disorder. The risk of malignancy is not increased.
PMID: 11772912 [PubMed - indexed for MEDLINE




476246 tn?1418874514
I would rather think that it has something to do with the lobes of the liver.... as she has had a liver biopsy and not a breast biopsy....

'But breast lumps have many causes. One surprising cause that's little known-even among doctors-is diabetes. Diabetes can cause dense fibrous lumps in the breasts. This condition is called "sclerosing lymphocytic lobulitis" or "diabetic mastopathy." It usually occurs in people who have an autoimmune disease (one in which the immune system attacks the body's own tissues).'

If you look at Janis and friends site, you will see that spotty is the same as focal... So my guess is that it might mean spots or foci of necrosis (dead cells) found on the lobes of the liver..

Marcia



568322 tn?1370169040
The liver is organized into lobules which take the shape of polygonal prisms.   Each lobule is typically hexagonal in cross section and is centered on a branch of the hepatic vein.  Here's a nice picture....

http://www.siumed.edu/~dking2/erg/liver.htm


and "itis" means inflammation.  So.....lobulitis means inflammation of lobules.
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