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Long term use of Imuran

My father has been taking Imuran to help with a Hepatitis problem in 1997.  He has been taking it for 4 years and now he is so weak and thin and has uncontroled diarrhea.  The diarrhea is a recent problem.

Question:
Is long term exposure to Imuran potentially dangerous.  Have these symptoms been documented before?

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