Is there any harm in taking too much milk thistle?
I take 1000mg daily and have for about 4 years. I don't know if there is any corolation, but my ALT and AST have dropped 50% in the past two years. This shows liver swelling down 50%. The Gastro said this is an indication that the virus is being contained and not spreading as rapidly. The Hepatologist said "it couldn't hurt" in taking Milk Thistle. Europeans have been taking it for many years for liver problems. Otherwise, it's up to you...
I take 2500 mg's a day and have been for over 5 years before that my ALT and AST were between 70-90 nd in the past 4 years they have been normal. My last blood test were both in the low 20's. It made my GI a believer. He used to say the same thing as Magnums Hep "it couldn't hurt". I wouldn't take any more than what I am taking now and would recommend you starting off with a 1000mg.
I take 150mg 2x day. How did you all arrive at 1000 and 2500mg. May need to increase mine.
Where can I find milk thistle?? And can I add that while taken pegasys and ribavirin?? Thanks in advance!!
Puritan's pride has Milk Thistle in a 1000mg pill, I use them because consumler Labs testing them to be accurate. Nazzareno I read how most of the supplement is not absorbed and talking with my GI decided to increase my dosage. I did it gradually over a few years. Stick with a 1000mg for awile. I get blood test done every 4 months.Selenium is also a good supplement at 200mcg a day and R Alpha Lipoic Acid, I take 300mg a day.
OK, the pills I have state that they are 325mg of Milk Thistle Seed and 75mg of Milk Thistle Seed Powder Extract Standardized to 80% Silymarin. So is this a 325mg pill, a 400mg pill or something else based on the 80% Silymarin statement? The label's "Suggested Use" statement indicates to take "1 capsule 3 times daily". Would that be a 1200mg regimen per day?? What is the difference between the seed and "seed powder extract"?
I've been taking 1 daily, but the prior posts make me wonder if I'm just wasting my money by taking too little for it to have any effect.
For those concerned about taking too much, here's this passage from the wikipedia silymarin page at:
"The acute toxicity of silymarin and silybin were investigated by oral and intravenous route in various animal species. No mortality or any signs of adverse effects were observed after silymarin at oral doses of 20 g/kg in mice and 1 g/kg in dogs. The 50% lethal dose (LD50) after intravenous infusion values are 400 mg/kg in mice, 385 mg/kg in rats and 140 mg/kg in rabbits and dogs. These data demonstrate that the acute toxicity of silymarin is very low.
Similarly, its subacute and chronic toxicity are very low; the compound is also devoid of embryotoxic potential."
You can buy it at Wal-Mart. It's the Spring Valley brand at 90 softgels @ 1000mg. each.
About $6.50. That will last you about 3 months @ 1 softgel per day.
Thanks Magnum!! Thanks to you to Boo, but I have no idea what a Puritans Pride is!! Lol
Does it matter what brand you take? I have heard people say that some brands like the stuff you can get at walmart or CVS.... is not very goodl can you just take silymarin supplement since that is the active ingredient in milk thistle? I think I have seen both in the health food store.
Thanks. I just bought some over the internet. Was buying a more expensive brand and taking 3 times a day . It was doing anything for me, maybe the brand or not enough dosing. I'll try the one from Walmart. Can't beat that pricing.
Yes I agree. I do buy the brads at wal-mart but they contain little of silymarin.I take 4000-6000 mg a day just to get the desired dose of silymarin…
Puritans Pride is the maker .Google it and youll find they make every vitamin know to man!!!
Doc told me NOT to take it ON treatment so check that out.
I saw one study that said the Walmart brand, Spring Valley, had the most honest contents. This was for knee joing stuff, you know, those two items, can't remember the names.
Maybe I will start taking Walmart or Puritan. Spending a furtune on Life Extension super whatever. Don't think I'm getting 1000mg a day however. god I spend so much money on these nutrients. But smarter to do that, follow suggestions here by HR et al, than not to. . . .
Cindy, the article quoted above is interesting, but the overview itself is written by Nicole Cutler, L.Ac. This is a degree for acupuncture, so I’m not sure she herself is qualified to provide advice. The references to published, peer reviewed journals of course might carry some weight. Her summary at the end sounds like sage counsel:
“Experts agree that more well-structured trials are needed to understand, quantify and verify silymarin's effectiveness against the Hepatitis C virus….”
And again I do not believe we are supposed to take it while on treatment so be careful. Whether it has merit or not I thought that was a foundational belief around here....
Acupunturists advising supplements well go figure!
Just dont put too much stock in anything really helping you that much except killing off the virus - at the end of the day all else is hopeful at best and that's about it.
I will check before I take it, I've got a call in to the doctors office now.. Thanks guys!!
Just talked to my doctor and he said it was fine to take the milk thistle while on treatment!!
Guess your doctor knows something many others don`t.
i am usually all for protecting your liver , slowing and or reversing fibrosis ect.... but NOT
while on treatment.
How do you know that Milk Thistle for example does`nt clear out SOC meds out of liver
to quickly by trying to detoxify it ?
What can have a beneficial effect normally does not nessecarily mean it is good on tx.
Pre tx I took lots of quality pharmaceutical grade Milk Thistle from Germany so it was regulated with garanteed Silibin potencies It had zero effect on my viral load.
There are also absorption issues and there is a trial where Silibin is administered
intraveneously also in Germany that showed some response but it had to be done very often
meaning you end up with an IV-pole next to you most of the time. End result only showed
a marginal HCV decline but no SVR as far as I remember. I studied that almost a year ago.
Missy I totally agree with Bali and we have discussed this many times over the years and whileI am no rocket scientist who can remember every detail I am relatively sure we are not supposed to take it exactly for that reason.
With any drug while ON treatment if you cannot 100% disprove that it will not cause any problem it's totally NOT worth taking it.
Treatment is hard enough to succeed with and beat this stupid disease but to give yourself less odds by accident?
I think if you put milk thistle in here in the search feature there will be 100s of doctors who have told thier patients fine but not on treatment.
I wonder why he would tell me that it was fine? I haven't taken any or even bought any for that matter.. I think I will take you guys advice. I wanna beat this crap.. Thanks!! :o)