Aquarius, dr carroll leevy, he is in newark. he was my first doc and is a very aggressive treater but to far for me to travel.
Copyman look at Susan400 who has treated like SEVEN times. I don't care how well meaning your doctor is...he cannot guarantee you that he will "cure" you. No way. It's a nice thought but...just ask someone like Susan who has done EVERYTHING possible and still..............
As an F0 if I was you I would wait instead of doing the meds and see what happens with not only Vertex but the others.
You really aren't in a rush unless you want to be and remember there is NO guarantee. He can be the nicest man in the world and talk your ear off but that piece of advice is just not right.
I do love his "fight" approach though!
Pretty interesting! Hope I don't get in trouble for copying part of the article here, but I live dangerously. FInally something GOOD to come of fat!
Here's the link http://www.yomiuri.co.jp/
Liver Cell Created from Subcutaneous Fat
The Yomiuri Shimbun
A team of doctors has succeeded in creating a hepatic cell out of subcutaneous fat, a development that might lead to a regenerative medicine technique that would enable patients with hepatitis or cirrhosis to have their livers repaired.
More than 3.5 million people in Japan suffer from the diseases, and clinical application of the team's findings is being eyed for sometime in the next few years.
According to the National Cancer Center Research Institute and the International Medical Center of Japan, the doctors used a cell called mesenchymal stem cell that accounts for about 10 percent of the subcutaneous fat tissue of a human body, believing the cell has the potential to change into different cells that make up various organs or other tissues. In the research, five grams of subcutaneous fat was taken from each of seven patients who underwent abdominal surgery at the International Medical Center of Japan, and the mesenchymal stem cells were extracted from the fat tissues.
The researchers added three types of proteins that prompt growth to the stem cells, and incubated them for about 40 days.
As a result, nearly all cells turned into hepatic cells, according to the doctors.
At least 14 types of proteins, including albumin--one of the major components of blood--and drug-metabolizing enzyme, that are known to be synthesized only in the human liver, were detected in the incubated cells, the doctors said. Then the researchers injected about 1 million incubated cells into lab mice that were artificially made to develop liver malfunctions.
The ammonia level in the mice, which had been rising before injection, dropped to a normal level in one day, the doctors said.
Regenerated subcutaneous fat cells have already been used in some clinical practices such as breast reconstruction, but this is the first time in the world that more than one function for the human liver has been observed in the regenerated cells, according to the research team.
While the most highlighted technique in regenerative medicine is embryo-stem cell development, it has been criticized because it utilizes fertilized egg cells.
The use of subcutaneous fat cells, on the other hand, faces fewer obstacles in terms of life ethics, and are advantageous because they can be taken from patients' own bodies to eliminate the risk of rejection, the doctors said.
Takahiro Ochiya, head of the Section for Studies on Metastasis Research at the National Cancer Center Research Institute, who led the team of researchers, said: "I would give 60 out of 100 if I were to grade the hepatic cells we made from subcutaneous fat for their performance. They barely pass the test at the moment, but we would like to go on working to make cells that perform like real hepatic cells."
Yasuyuki Sakai, associate professor of the Center for Disease Biology and Integrative Medicine at the University of Tokyo, hailed the team's findings as a "remarkable achievement," but pointed out that several issues need to be addressed before clinical application. "To achieve a certain level of therapeutic effect from a patient with liver disease, more than 10 billion hepatic cells have to be implanted into his or her liver. To reach the goal of clinical application, researchers must develop a technique to more efficiently make hepatic cells from a large amount of subcutaneous fat," Sakai said.
Copy,
Forgot you haven't had a needle biopsy and are basing your FO solely on Fibrosure? If so, def get scan with Dr.A, but why not simply do a needle biopsy as a geno 1? Personally, I'd try for both. In any event, consensus seems to be to wait for better treatments, assuming you really have little or no liver damage while monitoring liver. I somewhat disagree with others and do feel that a doctor can right now pretty much "guarantee" SVR in at least 9 out of 10 patients if you give him 3 or 4 shots and don't hold him to SOC. But again, at what cost?
HR,
HR: when HCV helper antivirals ( sorry Jim, I have to call them that)
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You can turn a phrase :) Of course, this is all to be seen, and I think you said once before that you hope you are wrong in this regards. BTW would appreciate your take on RTS' experience with supplemental testosterone post treatment. Was thinking about it myself for more energy,etc, but my levels are normal (59 years old) and RTS's I believe were low. I know there's a controversy about supplemental teststerone for those in normal range.
RTS,
Absolutely wonderufl things are working out. Can you tell us again what your tesosterone was prior to treatment, what supplementation you're taking and what you testosterone is now that you're taking supplementation. Also, any adverse sides from the thereapy?
Aquarius,
Two excellent doctors in NYC you might consult with: Dr. D. and Dr. J. Dr. J. does not accept insurance and a single consult costs around $600 as reported by one member here. You also might consider a trip to Boston to see Dr. A. who has a Fibroscan machine:
http://tinyurl.com/2axrsd
http://www.hepccenter.org/jacobson.php
http://bidmc.harvard.edu/display.asp?leaf_id=11676
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thanks for responding. he did say one of the options was to wait with close monitoring of my liver until better meds come out ( i forgot to ask how long he thought before new meds would hit the market). so far i have read up on the Taribavirin and this does not look that much better then ribavirin except with much less anemia but svr about the same. as geno 1a my main objecttive is to treat less time with goods odds of svr, and i think with less tx time, there are less post tx problems. what scares me the most is doing 48 weeks of tx with only a 50/50 chance svr, maybe relapsing and being worse off then iam right now, plus the possibility of living with post problems for the rest of my life. would i be able to get the "scan" without a bx? since my doc knows him real well could he ask him to make an exception if bx needed.
i never followed up with that TCM doc but if i do i will let you know unless you want the link for his website?
my tx meds are coming in the mail on thursday, this time for sure. i am in NJ and would like to know if there's a good doc here, or jmjm you had said nyc. i don't know how much knowledge my doc has, but i want to make sure i have one that knows alot about this disease. the last time i went to my gastro, i had picked up a copy of my bx, just in case my dos didn't receive it, since they said they'd call when they got the results, but didn't. my doc says, no i don't have your results when i got there, then low and behold, she doublechecked and it was right on the front page of my med file, DAH! just want to know i have a good doc. if either one of you know a doc, i am in monmouth county, nj. thanks so much.