hey thanks for the memories! interesting reading, I found that glucose article particularly interesting....be well...
I jumped right in looking for the generic riba info you so graciously dug up. The first link in the paragraph (here) did not link for me. The other two links were non-specific for the riba. I wonder if the first link rated the generic riba since bioavailability is what we are always looking for -- is it AA or AB or B-
Other articles look interesting too, but this is the one I am interested in at present
I, too, just checked and for some unknown reason the link is not working.
The jist of the search results is that the majority of the generic riba approved is rated "AB" by the FDA, thereby meaning that:
"<i>A Drug products that FDA considers to be therapeutically equivalent to other pharmaceutically equivalent products, i.e., drug products for which:
(1) there are no known or suspected bioequivalence problems. These are designated AA, AN, AO, AP, or AT, depending on the dosage form; or
<b>(2) actual or potential bioequivalence problems have been resolved with adequate in vivo and/or in vitro evidence supporting bioequivalence. These are designated AB</b></i>".
Thanks for the links. Still trying to figure out whether ribasphere is AA, AB, or other. Anyone figure that one yet?
The EPO article from the first list is pretty interesting. Not so much for the results of using EPO, but rather the dramatic improvement in SVR rates acheived by bumping up ribavirin dosage from 13.3mg/kg to 15.5mg/kg. Overall, SVR rates seemed low in this study, but the group with higher riba dosing fared much better (as in like double the SVR rates).
Looks like the stepped up dose works out to about an extra 200mg pill per day. Conveniently, just what I happen to take. Helps make all the huffing and puffing just a little more palatable!
Tn,Thanks, I guess my take is still that AA (being the standard for the name brand) is more bioavailable than a AB (like most generics) even tho the standards are close (close only counts in horseshoes, as they say). I think then it becomes a matter of money. If the difference is not great, go with the name, if money is an issue, go with the generic, as the difference is minor.