Aa
A
A
A
Close
Hepatitis C Community
13.4k Members
Avatar universal

One Shot Deal??

If a person is treating with the PI drugs and fails to get SVR.does it mean that you cant use the PI`s ever again.this is what im gathering from what ive been reading ...looks like its do or you know what....man...sometimes i wonder how i deal with all thie stuff.
3 Responses
412873 tn?1329174455
I'm trying to get through this article.  At the very least, I know 'they" are working on it now...more than I ever imagined, but until then the way I understand it is that you can not re-tx with the same PI....but another one could possibly work.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2395260

Yeah, I agree....what did I do in my spare time before all this, lol!

Hope you are doing well.
732047 tn?1236010444
That's the way I understood it as well. I think the mechanism for failing to clear with a PI is a mutation of the virus. This would render the PI that caused the mutation ineffective.

A video I saw on this subject led me to believe that the researchers have a pretty good idea of which mutations are likely depending on which PI is used based on data collected from the clinical trials.

If I were to not SVR with a PI then I would probably wait for a possible ProteaseI/Polymarease inhibitor combo such as the ones being tried in the INFORM 1 trials.

The theory is that any resistance that developes to one of the drugs would most likely   not be resistant to the other drug

Of course I could have completly misunderstood the material being presented on the video.  But it sounds good to me. :)
408795 tn?1324935675
Yeah it's one tx per patient.  The link Izzy posted shows the mutations that telaprevir guards against.  All the PI's that are made do the same thing, but they do it differently.  They work at killing the virus, while preventing a breakthrough from taking place.  no worries, you're in the SVR car


fret
Have an Answer?
Top Hepatitis Answerers
317787 tn?1473358451
DC
683231 tn?1467323017
Auburn, WA
Learn About Top Answerers
Didn't find the answer you were looking for?
Ask a question
Answer a few simple questions about your Hep C treatment journey.

Those who qualify may receive up to $100 for their time.
Explore More In Our Hep C Learning Center
image description
Learn about this treatable virus.
image description
Getting tested for this viral infection.
image description
3 key steps to getting on treatment.
image description
4 steps to getting on therapy.
image description
What you need to know about Hep C drugs.
image description
How the drugs might affect you.
image description
These tips may up your chances of a cure.
Popular Resources
For people with Obsessive-Compulsive Disorder (OCD), the COVID-19 pandemic can be particularly challenging.
A list of national and international resources and hotlines to help connect you to needed health and medical services.
Here’s how your baby’s growing in your body each week.
These common ADD/ADHD myths could already be hurting your child
This article will tell you more about strength training at home, giving you some options that require little to no equipment.
In You Can Prevent a Stroke, Dr. Joshua Yamamoto and Dr. Kristin Thomas help us understand what we can do to prevent a stroke.