my thoughts and sympathies continue to be with you. You are pretty darn tough. Hope this is the cure for your rash, then onto dealing with the rest of killing the virus.
What you have gone through should help alot of other people as they go down the same path.
I am glad your derm doc is doing something about the rash. I also agree that had your treating doc acted sooner to prescribe stronger meds (than OTC), your rash may not have gotten so severe.
I looked on Drugs.com and found no interactions between Pegasys, Riba, and Kenalog inj. It is Incivek that may cause increased plasma concentrations of systemic steroids.But you stopped Incivek on March 31. I don't think you have to skip any Pegasys injections but perhaps check with your specialty pharmacy to be sure.
Drug Interaction Results:
Ken-Jec 40 (triamcinolone)
Pegasys (peginterferon alfa-2a)
"GENERALLY AVOID: Coadministration with telaprevir may increase the plasma concentrations of systemic corticosteroids. The mechanism involves telaprevir inhibition of CYP450 3A4, the isoenzyme primarily responsible for the metabolic clearance of most steroids. No pharmacokinetic data are currently available, although telaprevir is a potent CYP450 3A4 inhibitor and may interact significantly."
"MANAGEMENT: The use of systemic corticosteroids in combination with telaprevir is not recommended. Systemic corticosteroids should not be used to treat telaprevir-induced rash."
So glad you are finally getting the derm care you need. Hope the rash clears soon.
So happy that they are finally seeing the torture that you are living with. My best to you sweetie. Hang in there and keep us posted..
Aw Sweety, this is just awful. I can imagine how distressed you must be. And angry. I don't know much about the rash other than it's a good thing, STS, DRESS & TENS have been ruled out.
The only info I have seen is stuff you probably have already seen on the Internet. The difference being if your Derm is right, then you fall into the "Severe category" at the bottom"
1. Discontinue INCIVEK
2, May continue pegIFN-RBV
3. Closely monitor for signs of progression
4. If rash does not improve within 7 days of INCIVEK discontinuation (or earlier if worsening rash), consider interruption or discontinuation of RBV and/or pegIFN
5. Earlier interruption or discontinuation of RBV and/or pegIFN-RBV may be needed if medically indicated.
In other words, it seems like how well you heal or progress in the next few days may be an important determinant as to how (and if) you proceed with treatment.
Of course, all in all it looks like you really need to be monitored more often and keep in touch with both doctors.
I had two horrible rash/infection/non-healing ulcerations after I treated last time. I did not clear the virus but was left with this painful unsightly skin condition. I had a once a week appointment with my Dermatologist for almost two months and then after that it went to once every two weeks. It was really just to be sure other weird things didn't start happening and to ensure I was healing.In my case that many visits helped since things *did* get worse before they got better.
I am not trying to bum you out or scare you, just to encourage you to do the same thing since it truly seems very little is really known about all the various skin conditions that are related to Incivek.
I hope you can continue treating.
So either way I wish you much luck with this and some peaceful healing.
Hmmm, I dont know anything about the steroid shot, and Pegasys, it would have been nice if your Treatment Doctor had let you know what his plan is, but it sounds like you are going to have to wait for your next appt with him?
I did come up with a link, which backs up what my Hep Doctor told me, which is that the PI's have tolerance/resistancy probs (but you are off now) but that Interferon and Riba dont- http://www.hcvadvocate.org/hepatitis/Basics/New%20Antivirals.pdf
I hope the cortisone is effective!
Thanks so much for the comments so far. Pooh, that excerpt is the exact excerpt I am going to force my doctor to read tomorrow....or I will read it to him. Or maybe just take the piece of paper and....well, you get the picture.
I have just been slathered head to toe with my topical cream, Desoximetasone, and am such a bright red I could be used as a lighthouse beacon.
I feel a little strange with a funny taste in my mouth. I guess I can attribute that to the shot.
I just hope I don't end up in the hospital over this.