Research supported antifibrotics - do they exist?

[Hepatitis Researcher]

The problems of treatment failure for SOC/IFN nonresponders and the possibility of reducing future supercombo-SVRchances by introducing archived resistance mutations when using "Pseudomonotherapy" - (that is here defined as using  a single  antiviral agent that is not protected against resistance development by its combo with an IFN/riba component (IFN by definition in this scenario is not sufficiently effective in reducing viral replication so that all the burden to tame the adaptive quasispecies evolution falls on the antiviral)) together with the 61% and 65% SVR rates for the latest triple modality in Geno 1s, have raised concern and the awareness for the need for alternate/additional treatment modalities in many HCV patients and their health care providers. Waiting for future antiviral developments is one route frequently recommended, but for the patients  in current need, our repertoire of additional meaningful approaches needs to be carefully reevaluated. Using antifibrotics to halt fibrosis progression is one concept not proven in large trials but it might well be effective in many, because the mechanisms for fibrosis generation are not intrinsically linked to HCV persistence, but rather to secondary response mechanisms evoked in the chronically inflamed liver, with the stellate cell activation holding center stage in this scenario. The following is one of several possible add on modalities.

[evangelin]

For those of you who weren't here to benefit from HR's posts, here is one of the many gems he left in the Medhelp archives.  It also shows you why it is difficult to give a cut and dried list of which supplements he said to take .  It came with very detailed and complex explanations in an attempt to help us navigate through that which had the potential of helping and that which did not.  PPC alone took a lot to explain . Anything with the name Polyenylphosphatidylcholine (PPC) was bound to be a little complex.  :>)  HR took a lot of painstaking time to explain why phosphatidylcholine nor choline were going to do the job of reversing fibrosis.  
This thread was really long and likely only the desperate will have the stamina to read all of it.  If you do, you will see that St. George posted quite a few times.  
I was in the desperate club when I spent days on end reading and studying to understand his posts.  
If you note my post above from 2007, it  shows me to be the same person as I am in 2011 except that Joe has one more TX failure under his belt.  Why would I not have great regard for him for the help he freely gave.  He was a "suit" and TX was first but he was a realist and understood the unmet need.

[mhudnall]

Just giving a bump to a very good previous discussion thread on the subject of PPC by HR and others. I think many will be interested, if they haven't already seen this thread.

BTW, the recommended product line, Hepatopro contains 30% ethanol; a fact that is not hidden, but also not well disclosed. At the time of this thread it was probably the best product out there. However, there is a new product line available now that contains no ethanol and is high quality. If anyone is interested send me a private message and I will tell you the source.

[KettyJohnson]

Thanks for a healthy and helpful discussion, you may also check this link for more information

http://allnutri.com/nattokinase.aspx

[CockSparrow]

mikesimon-I feel I am in rarefied company when I read your posts
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I feel like spending the next three days trying to figure out what was said.

Good way to learn though.
CS

[GoofyDad]

Thanks for that. Like a good bowl of spinach - it will take a while to digest. At the risk of oversimplification - it sounds to me that the take away is: NO enhancement is generally a good thing - unless the liver is obviously past the 'tipping point'.....

[St. George]

I didn't use Glisodin through my failed treatment but do you think it may have added some benefit to the battle?  Do you think SOD overall in any form(injectable) would have a certain synergy with interferon?