Research supported antifibrotics - do they exist?

[Hepatitis Researcher]

The problems of treatment failure for SOC/IFN nonresponders and the possibility of reducing future supercombo-SVRchances by introducing archived resistance mutations when using "Pseudomonotherapy" - (that is here defined as using  a single  antiviral agent that is not protected against resistance development by its combo with an IFN/riba component (IFN by definition in this scenario is not sufficiently effective in reducing viral replication so that all the burden to tame the adaptive quasispecies evolution falls on the antiviral)) together with the 61% and 65% SVR rates for the latest triple modality in Geno 1s, have raised concern and the awareness for the need for alternate/additional treatment modalities in many HCV patients and their health care providers. Waiting for future antiviral developments is one route frequently recommended, but for the patients  in current need, our repertoire of additional meaningful approaches needs to be carefully reevaluated. Using antifibrotics to halt fibrosis progression is one concept not proven in large trials but it might well be effective in many, because the mechanisms for fibrosis generation are not intrinsically linked to HCV persistence, but rather to secondary response mechanisms evoked in the chronically inflamed liver, with the stellate cell activation holding center stage in this scenario. The following is one of several possible add on modalities.

[viaduk]

"But I do know that the cocktail has worked very well, with dramatic reduction from cirrhosis..."

Would you  be willing to elaborate on the therapeutic dosage for the various substances that you mentioned ealier in this thread?  I tried to find your previous posts regarding this approach, but the search function here is not very helpful.

Thank you.

[GoofyDad]

HR - You might consider copying long posts into notepad temprarily as a back-up - or start in notepad....


whrose: if you didn't see this...
http://www.medhelp.org/forums/hepatitis/messages/44479.html

[JRenquist]

Never mind the last post.  They are out of it at iherb.com now (probably from everyone reading hepatitisresearcher's posts)  

[JRenquist]

Thanks so much for the info and for using your time to help us. I'm going to try the regimen you would use for your imaginary child, if I can find the 2 components I don't yet have. They have the hepatapro at iherb.com for 25% off retail. I usually find the best prices there.  S.

[Hepatitis Researcher]

Lost another lengthy post - landing in a spinal therapy center??
So briefly:
Your liver to lover slip of fingers was not so far off : These substances will definitely improve endothelial function - the production of NO............

[Whrose]

ahhhh i meant liver.....not lover...LOL but then again i am a liver lover ;)