Research supported antifibrotics - do they exist?

[Hepatitis Researcher]

The problems of treatment failure for SOC/IFN nonresponders and the possibility of reducing future supercombo-SVRchances by introducing archived resistance mutations when using "Pseudomonotherapy" - (that is here defined as using  a single  antiviral agent that is not protected against resistance development by its combo with an IFN/riba component (IFN by definition in this scenario is not sufficiently effective in reducing viral replication so that all the burden to tame the adaptive quasispecies evolution falls on the antiviral)) together with the 61% and 65% SVR rates for the latest triple modality in Geno 1s, have raised concern and the awareness for the need for alternate/additional treatment modalities in many HCV patients and their health care providers. Waiting for future antiviral developments is one route frequently recommended, but for the patients  in current need, our repertoire of additional meaningful approaches needs to be carefully reevaluated. Using antifibrotics to halt fibrosis progression is one concept not proven in large trials but it might well be effective in many, because the mechanisms for fibrosis generation are not intrinsically linked to HCV persistence, but rather to secondary response mechanisms evoked in the chronically inflamed liver, with the stellate cell activation holding center stage in this scenario. The following is one of several possible add on modalities.

[scratchinghead]

If you want to translate German to English go here.
It only does 500 characters at a time and isn't perfect. This was the first link I clicked on when I googled for "German translator":

http://translation2.paralink.com/


anywayGreysAnatomyisoverheadingtobedforevergratefultoallhepcresearchersthankyouverymuch

[GoofyDad]

HR - Thank you very much. Extremely enlightening.

Switching gears to the metabolic issues for a moment - what's your take on brown rice and whole grain pastas and the like - are they in the same verboten (see that!!) class as the rest of the starches?
----------------------------------------------
For all interested in PPC - here's how a vendor I contacted differentiates their PPC from PC...

Thank you for your recent inquiry and interest in PhosChol.  The prefix
"polyenyl" simply denotes that the phosphatidylcholine molecule is
polyunsaturated and is often abbreviated PPC.  PPC is used to describe
100%
purified phosphatidylcholine from Soy. There are no other competing
phospholipids in PPC.  When the term phosphatidylcholine is used in
studies
it generally refers to PPC, and therefore a purified
phosphatidylcholine.

Some studies will also refer to Lecithin being administered at 1.8 to
2.7
grams, and this is almost always referring to purified PC. Unless it
states
for example that a PC of 30% or an EPL (Essential Phospholipid) of 75%
purified PC is being used, it is almost always purified, pharmaceutical
grade PPC.
It is a huge nomenclature problem and very confusing.  

From a therapeutic perspective, PPC is vastly different than triple
lecithin, which is sold as Phosphatidylcholine.  Unless you are using
PPC
you are taking a phospholipid complex of some percentage of PC, usually
30%,
and a variety of other phospholipids.  This is important as only PPC
can
deliver a therapeutic dose of 1,2 Dilinoleoylphosphatidylcholine
(DLPC).

As for the taste of the liquid, it's certainly not sweet, but it's
definitely manageable to take and has a slightly medicinal and nutty
flavor.
It can always be mixed with something like applesauce, cottage cheese,
a
smoothie, juices, or oatmeal (once it has cooled) just to give you some
ideas.

[ruth709]

halo,guys....can anybody help me interpret the result of my med test a while ago...thnak you very much.

SGPT: 58.10   normal value should be 0-49 mg/dl
Hbs Ag Sreening Test: Reactive

Thanks again!

[Hepatitis Researcher]

The main post to Drofi was in English, the extra one was in German, since it contained a response to a slightly emotional reaction on his part to my critical view of the German website that he posted with re to  the antinflammatory substance. The ultrafine nuances that i can use in the German language with him was intended to settle this very peacefully.

Thank you all for your good support and the friendly words.

[Hepatitis Researcher]

The polyunsaturated tail, not only improves membrane fluidity, but more importantly allows the PPC molecule itself, due to its stiffer , unsaturated backbone, to be less attached to its immediate membrane environment and move laterally and rotate much quicker around, serving its biochemical purposes in a more effective way. Please consider that the membranes in a cell are not just the surface membrane, but numerous inside membranes as well as in the double mitochondrial membrane.PPC will be in all of these.

[scratchinghead]

gazuntite! volkswagen! porsche!