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7510956 tn?1411675017

SOVALDY AND OLYSIO MEDS SAME DOSAGE FOR ALL?

I read this question in another site and it made me think. The dosage for Sovaldi (400) and Olysio (150)  is the same for all, other meds like Riva can/are adjusted. A male at 260 lbs takes the same dosage as a female at 120 lbs, I would think the female would have more in her system because of her size and have more sides and/or better results. Whats the science behind same dosage fits all?    
8 Responses
Avatar universal
My husband and I have discusses this very thing w/Sovaldi and these new drugs coming out.

Don't have an answer for you, but agree that is a very valid question.  

Anyone know?     Pat
683231 tn?1467326617
Well if you think about it how many medicines are dose adjusted by the size of the patient.

Aspirin take 2 and call me in the morning (well except if you have cirrhosis) does that mean the meds are more effective for smaller people or are all smaller people getting over dosed.

I think it is more because ribavirin is so toxic they want to ensure smaller people dont get too much of it.

Only the chemists know for sure :-)
Avatar universal
Or the larger are being under-dosed. :)
7510956 tn?1411675017
I agree only the chemist could answer the question but I would think it would cost them less money to produce one item for all instead a couple. It would cost more money for research and approval, I think...
Avatar universal
Come to think of it, perhaps that's why men have less sides.
1747881 tn?1546179478
Sofosbuvir Advisory Committee. October 25, 2013.

Clinical Pharmacology in Special Populations

No CYP450 hepatic metabolism

No dose adjustment in hepatic impairment

No dose adjustment if creatinine clearance >30 mL/min

No impact of HCV patient characteristics
on exposure – No impact of BMI, age, sex, race, or cirrhosis
on pharmacokinetics

http://www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials/drugs/antiviraldrugsadvisorycommittee/ucm375286.pdf

"Only the chemists know for sure :-)"
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