My husband and I have discusses this very thing w/Sovaldi and these new drugs coming out.
Don't have an answer for you, but agree that is a very valid question.
Anyone know? Pat
Well if you think about it how many medicines are dose adjusted by the size of the patient.
Aspirin take 2 and call me in the morning (well except if you have cirrhosis) does that mean the meds are more effective for smaller people or are all smaller people getting over dosed.
I think it is more because ribavirin is so toxic they want to ensure smaller people dont get too much of it.
Only the chemists know for sure :-)
Or the larger are being under-dosed. :)
I agree only the chemist could answer the question but I would think it would cost them less money to produce one item for all instead a couple. It would cost more money for research and approval, I think...
Come to think of it, perhaps that's why men have less sides.
Sofosbuvir Advisory Committee. October 25, 2013.
Clinical Pharmacology in Special Populations
No CYP450 hepatic metabolism
No dose adjustment in hepatic impairment
No dose adjustment if creatinine clearance >30 mL/min
No impact of HCV patient characteristics
on exposure – No impact of BMI, age, sex, race, or cirrhosis
"Only the chemists know for sure :-)"