Also,
Beef Fat Prevents Alcoholic Liver Disease in the Rat
Amin A. Nanji MD, FRCP(C), Charles L.
The amount and type of dietary fat is thought to be important in the pathogenesis of alcoholic liver disease (ALD). We investigated the role of different dietary fats in our rat model for ALD. Liver pathology was evaluated in rats fed ethanol and lard or tallow or corn oil over a period of 2 to 6 months. All experimental animals were pair-fed the same diet as controls except that glucose was isocalorically replaced by ethanol. Rats fed tallow and ethanol developed none of the features of ALD, those fed lard and ethanol developed minimal to moderate disease, rats fed corn oil and ethanol developed the most severe pathology. The degree of histopathological abnormality correlated with the linoleic acid content of fat in the diet (tallow 0.7%, lard 2.5%, corn oil 56.6%). We postulate that linoleic acid facilitates development of ALD and provides an explanation for our previous epidemiological observations.
And one more:
Effect of Dietary Fat on Ito Cell Activation by Chronic Ethanol Intake: A Long-Term Serial Morphometric Study on Alcohol-Fed and Control Rats
Hisao Takahashi, Kim Wong, Linda Jui, Amin A. Nanji, Charles S. Mendenhall, Samuel W. French
(note: Ito Cells are Hepatic Stellate cells in their normal state. This study is saying that rats fed beef tallow had no loss of Ito cells – that is, no conversion to myofibroblasts – whereas rats fed corn oil went into fibrosis)
We studied the effects of long-term ethanol ingestion and dietary fat on Ito cell activation morphometrically in rats. Sixteen pairs of Wistar male rats were divided into two groups, one fed tallow and the other fed corn oil as the source of dietary fat. Each group of rats were pair-fed a nutritional adequate liquid diet containing either corn oil (CF) or tallow (TF) as fat as well as protein and carbohydrate. Half of each group received ethanol, the rest were pair-fed isocaloric amounts of dextrose via an implanted gastric tube for up to 5 months. Morphometric analysis of the change in fat and rough endoplasmic reticulum (RER) of Ito cells was performed on electron micrographs obtained from monthly biopsies including baseline. Ito cell activation was assessed by a decrease in the ratio of fat/RER in Ito cells. The ratio of fat/RER in Ito cells of alcoholic rats fed the CF diet (CFA) gradually decreased. The ratio war found to be lower than in the pair-fed control rats (CFC) at 5 months of feeding. CFA 1.74 ± 0.57, vs. 7.46 ± 2.05, respectlvely, p < 0.05, mean ± se). Ito cell fat also significantly decreased at 5 months of feeding (p < 0.05). The fat/ RER ratio In CFA significantly decreased only subsequent to the development of fatty change, necrosis, and inflammation followed by fibrosis of the liver. In contrast, the TFA rats did not show a significant decrease in the fat/RER ratio in the Ito cells throughout the study, while TFC rats showed an increase in the fat/RER ratio. Minimal pathological changes were observed in the livers of CFC, TFA, and TFC rats. These results indicate that activation of Ito cells at a significant level occurred only late in the course of feeding alcohol after moderate to severe abnormalities in liver histology had developed, although activation may have begun at an earlier time of ethanol feeding. The results indicate that dietary fatty acid composition may be an important factor in the pathogenesis of ethanol-induced Ito cell activation.
Good sources of saturated fat are organic butter, palm oil and coconut oil.
If saturated fats can prevent fibrogenesis in the presence of ethanol, then is it not a far leap to assume the same of saturated fats and the presence of hep c virus?
Also, I guess you have to eat fatty meat but bake it, not grill it?
Mike
It won't be real hard to convince Joe to eat more butter. :>) Now he gets coffee, dark chocolate AND butter! Life is good.
Ev
yea butter!
On the other hand, corn oil and vegetable oil look like pure poison.
Interesting to read but we still have to limit our fat intake. Diet is often a double edged sword. Loading up on fats that may inhibit the fibrosis could cause us to have new different problems, such as cardiovascular issues.
http://www.mayoclinic.com/health/fat/NU00262
Further.... I think there are other issues which can come into play. Meat may just be meat, but when you grill it the composition changes. I believe that is one reason that high temperature grilling has gotten some bad press as of late.
I wonder, are nuts not high in saturated fats? It could be that nuts could be a better choice than a grilled 1/4 pounder.
best,
Willy
I've always been impressed about you concern for Joe and the level of interest that you take in his care and his health. But, keep in mind that these are RATS and extrapolating to you dear hubby might not be a sound approach. What I find interesting is the lack of follow-up on these poor animals, did their hearts explode and did they expire with little fibrosis but massively clogged arteries?
Good points. I agree, raw nuts may be one of the better sources of saturated fats. And huge amounts of anything might have massive unintended consequences.
I think it is obvious, however, that vegetable and corn oil are things to stay far away from. And not just because of these studies. Omega sixes feed directly into the arachidonic acid pathway (inflammation).
The things that drives me nuts (no pun) is some of the counter-intuitivness of some of this stuff. You'd think, in general, that for human purposes that derivitives of plants = good and derivitives of animals = bad (again, in general).
I was wondering how omega 3 fats fit into this.
I took a look at my flax seed oil.....
One TBSP (14 g) = one serving
total calories from Fat 120
TOTAL Fat 14 g
saturated fat 1.5 g *
Trans fat 0
Poly unsaturated fat 10 g *
Mono unstaturated fa t 3 g *
Hmmmm ..... not that impressive
Those items with an asterisk contain the disclaimer daily value not established, and the set up seems to emphasize the health, but possibly minimize the less stellar aspects of the product.
On that note...
Omega 3 (alpha linolenic acid, ALA) 8 g
Omega 6 (linoleic acid) 2g
Omega 9 Oleic acid) 3 g
What it means, I do not know...... but I assume that we cannot escape the so called "bad" and that all things in balance it may all work out. WE can eschew the worst of the worst and limit our intake of things we know to be bad.
Willy
Thanks, I will definitely keep it in moderation.
I agree with the counterintuitive part too. I really thought I was doing something good for him when I MADE him be a vegetarian for his own good. It turned out to be the wrong move entirely. He ate plenty of eggs and some beans and nuts but as soon as I got convinced that the latest studies say extra protein is needed for cirrhosis, his sorry looking albumin number went up.
In all my zeal to help Joe, I have made some blunders. I also used to be stingy with coffee because I thought it wasn't good for him and that turns out to be a mistake too. Left to his own devices, he would have eaten protein, coffee, and butter for sure. He would have added cherry pie and any day now there will be another article suggesting cherry pie would have helped too. :>) Hopefully, I will get points for trying hard but I have missed the target a lot.
Joe liked nuts all his life and liked them unroasted and raw even. I had him eat them with the riba on his last, long, nauseaus TX and not surprisingly, he doesn't seem to like them much at all now.
"And huge amounts of anything might have massive unintended consequences."
Now you tell me.
I just had a 1/4 cup of bacon fat poured on top of my morning oatmeal. : (
Willy
I ain't no rat and I ain't too keen on all that saturated fat and neither is my weight nor my cholesterol
About a week ago I was on some nutrition website (not sure which one) and I was looking at some of the health traits of various fruits. Mostly, I was researching "glucose friendly" stuff but several other attributes were discussed too. Although I can't find the site right now my impression was that cherries were more good than bad. Around my house milk chocolate covered cherries are a bit hit and I'm glad that the wife and the kids attack them like mosquitoes on an open cut. When it comes to sweet snacks "more for them and less for me" is probably a good thing for me. Until someone mad a mistake and bought dark chocolate covered cherries. I'm the only one who like dark chocolate.
So my dilemma, convince myself that dark chocolate is a beneficial as coffee and consider eating the glycemic bombs as theraputic or act wisely and eat a chunk of cheddar cheese instead. Sometimes you just can't win.
You brought back an old memory. Joe and I were dating in 1982 and he was stocking and sweeping at Walmart while working on his degree. One night he just happened to mention that he ate an entire box of chocolate covered cherries for his dinner break at Walmart. I knew then that he needed me, bad. :>I
For fats, you need the proper proportion of omega 3, 6 and 9. I have to look up what is the ratio, but an overabundance of omega six is the worst. Steatosis (intracellular fat) is mostly composed of omega sixes. A certain percentage of omega sixes convert directly to arachidonic acid. The arachidonic acid pathway is the biochemical textbook definition of the inflammatory pathway.
Look at this quote from one of the above studies. "The degree of histopathological abnormality correlated with the linoleic acid content of fat in the diet (tallow 0.7%, lard 2.5%, corn oil 56.6%)."
So flax is much closer to the proper proportion of the three omega fatty acids, while vegetable and corn are heavily composed of omega sixes to the exclusion of the others. But no omega sixes is definitely bad for you too. You need the proper proportion.
I'll look it up and post it later.
"Omega-3 fatty acids can be found in far less foods than omega-6 fatty acids. Many people have a very low intake of omega-3s. Since omega-6 fatty acids compete with omega-3 fatty acids for use in the body, it is important to take these fatty acids in the proper ratio. The World Health Organization recommends a ratio of 5:1 to 10:1 omega-6 to omega-3. While a ratio between 1:1 and 4:1 is often considered as being optimal. Since most diets are very rich in omega-6 and low in omega-3, the ratio is often somewhere between 10:1 and 20:1. This is especially a problem with diets that are high in processed foods and oils. Oils like corn, safflower, sunflower and cottonseed are usually low in omega-3s. To balance the fatty acids out, it is important to eat a diet that is low in processed foods and with fat mainly coming from omega-3 fatty acids."
The omega 3,6,9 fatty acids are unsaturated. The harmful effects of saturated fatty acids, the fats studied in the tests above, have actually been overestimated, in my opinion. For instance, one of the amazing benefits of coconut oil include the fact that it helps burn fat, not accumulate it, in the body.
But all things in moderation...
"The things that drives me nuts (no pun) is some of the counter-intuitivness of some of this stuff. You'd think, in general, that for human purposes that derivitives of plants = good and derivitives of animals = bad (again, in general). "
Very good point/advice. It's important to think carefully about what we put in out body, especially when dealing with a chronic disease. 3 cups of coffee a day maybe okay if you don't have high blood pressure, 10 cups of coffee a day probably not good for anyone. Just jumping on the antifibrotic band wagon blindly is not a wise idea. (not saying anyone did)
"He would have added cherry pie and any day now there will be another article suggesting cherry pie would have helped too. :>)"
-------
That really made me smile! All we can do is work with what we know. I know if my husband were left to his own devices and I wasn't doing all this research, he would probably have convinced me that all fruit pies are good for cirrhosis! ;)
Regardless of points or not for trying, your efforts on Joe's behalf have my utmost respect and admiration.
mhudnall: Counter-intuitive but interesting data for sure. Thanks for the article. Though I must admit I'll keep it to myself quietly for comfort -- sharing this info with my cirrhotic husband who already has a debilitating weakness for butter-made confections may be too much of a good thing!
Eureka,
Hope you guys are doing OK.
I'm with you. I don't really think that Joe should be privy to that information either. Yummy fats, like butter, might be a slippery slope...pun intended :>)
Ev
so the frenchies can tarry at the wine trough as long as Bessy comes along???
Sweet.
but hey, lets get real, the long and short of it is the body uses different lipid chains to correct different problems.
Example...for years I had untreated thyroid disease and craved coconut...
then I read all hypothyroid people crave it...coconut, they all do crave it.
couldn't let it go,,,so studied it, and found out that high chain omegas correct thyroid deficiency....somehow, the body knows what the mind does not. Found this out in pubmed.
this same thing has been observed in animals ad nauseum by dept. of agriculture, animals know when they are low in a mineral for example, and go graze on the thing highest in that mineral....how do they know??? We are fearfully and wonderfully made!,
now I won't feel so guilty when I eat eggs...and butter...everyday. (one weakness I cannot quit).
But I think we need to look carefully at the other antioxidants, like cucurmin, like dashan, etc. If we can reduce inflammation without the extra fat it will be better for our heart and other systems don't you think?? Certainly our waistlines!!
I'm not up on the whole of the mechanism, but my guess is any fat is going to reduce oxidation by it's nature, HOWEVER....when we speak of saturated fats, they do NOT have one problem that oils often have, the high omegas don't oxidize at the same rate.
Things like cocoa butter, cocomut oil, etc can last years without refrigeration and without becoming rancid...they are much more stable that way.
And butter of course, and meat as well are much FRESHER fats....meat is consumed within days of slaughter, butter also has a high turnover rate....whereas oils can sit on the shelf for months or longer...and the "idiot health food nuts" made the industry remove the antioxidants BHA and BHT years ago. Which combined means your corn oil etc is much more likely to have a high level on oxidation when you use it....(unless like me you keep it refrigerated and also add your own BHT as I do).
My guess is that this rancidity is the greater reason that the saturates scored better....not because they are better as much as they are fresher and ergo have less peroxide, less free radicals will be formed ergo, and less irritation and inflammation, whereas any amount of rancidity will make any oil or grain more dangerous than healthful.
It's too bad the researchers did not know about the rancidity potion in this equation.
It's too bad the public doesn't know either. This is one case where the presevative in the oils made them far more healthful, but as usual the bigger the whiners, the more our government caves and gives the little pissants what they think is right...even though in this case, their enlightment had nothing to do with chemistry, and they've made us all a lot sicker as a result of their ignorance. Nothing is harder on the body than peroxide.
mb
There are two new new medical studies from the US; one shows that high-fat diets help burn liver fat, the other shows that low-fat diets are much more likely to cause fatty liver and inflammation.
If you try to avoid fat, you will eat more carbohydrate, and you'll get fewer nutrients with that. Animal fat supplies vit A, D, K2 and selenium and these are all things that get depleted in hepatitis, and depletion is a risk factor for HCC.
I think, along with Paul Jaminet and Kurt Harris, that there are three toxic nutrients:
Fructose - from sugar, HFCS, fruit juice (the amount in most fruit is OK in "moderation", whatever that means)
Wheat (and maybe other grains)
Omega 6 oils (other than olive oil which is only 9-11% - which would still be too high without the antioxidants of CPEV).
I am also concerned about galactose from milk, don't recommend low-fat milk or large amounts of milk other than butter, cream and cheese.
But I have less evidence for this.
I think Julia Child was right when she said it was ridiculous to be afraid of our food.
Being afraid of your food can not be healthy for you!